A5GN10 (RNPA_SYNPW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein component
Short name=RNase P protein
Short name=RNaseP protein
EC=3.1.26.5

Alternative name(s):
Protein C5

Gene names

Name:	rnpA
Ordered Locus Names:	SynWH7803_1899

Organism

Synechococcus sp. (strain WH7803) [Complete proteome] [HAMAP]

Taxonomic identifier

32051 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme By similarity. HAMAP-Rule MF_00227
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP-Rule MF_00227
Subunit structure	Consists of a catalytic RNA component (M1 or RnpB) and a protein subunit By similarity.
Sequence similarities	Belongs to the RnpA family.

Ontologies

Keywords
Biological process	tRNA processing
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC tRNA 5'-leader removal Inferred from electronic annotation. Source: HAMAP
Molecular_function	ribonuclease P activity Inferred from electronic annotation. Source: HAMAP tRNA binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 131	131	Ribonuclease P protein component HAMAP-Rule MF_00227		PRO_1000194681

Sequences

	Sequence		Length	Mass (Da)
	A5GN10 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: E8754B64D72FF5F6	FASTA	131	15,252
	10 20 30 40 50 60 MVLPASMRLR GHRCFDHLHR RGKRYYGTWM VLRKAPSNAK LLRRDIHGLL TQTQPHSCRI 70 80 90 100 110 120 AVVISGKVHK RAVVRNRLRR LLHDHLRLRF EARSTHSDVW LLISLRPGAD ADEANLLEEC 130 DRLLEEAGLQ P

References

[1]	Genoscope Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WH7803.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT971583 Genomic DNA. Translation: CAK24325.1.
RefSeq	YP_001225622.1. NC_009481.1.
3D structure databases
ProteinModelPortal	A5GN10.
ModBase	Search...
Protein-protein interaction databases
STRING	32051.SynWH7803_1899.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAK24325; CAK24325; SynWH7803_1899.
GeneID	5146470.
KEGG	syx:SynWH7803_1899.
PATRIC	23830000. VBISynSp43824_1947.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000266301.
KO	K03536.
OMA	MRLKGHR.
ProtClustDB	CLSK919642.
Family and domain databases
Gene3D	3.30.230.10. 1 hit.
HAMAP	MF_00227. RNase_P.
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR000100. RNase_P. [Graphical view]
Pfam	PF00825. Ribonuclease_P. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
PROSITE	PS00648. RIBONUCLEASE_P. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNPA_SYNPW

Accession

Primary (citable) accession number: A5GN10

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	June 12, 2007
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program