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A5GMT2

- GSA_SYNPW

UniProt

A5GMT2 - GSA_SYNPW

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, SynWH7803_1821
Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. chlorophyll biosynthetic process Source: UniProtKB-HAMAP
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Chlorophyll biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.
UPA00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:SynWH7803_1821
OrganismiSynechococcus sp. (strain WH7803)
Taxonomic identifieri32051 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001566: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_0000300953Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei272 – 2721N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiA5GMT2.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi32051.SynWH7803_1821.

Structurei

3D structure databases

ProteinModelPortaliA5GMT2.
SMRiA5GMT2. Positions 6-426.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiVATHTIT.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5GMT2-1 [UniParc]FASTAAdd to Basket

« Hide

MTAPTLNTTR SQELFSAAQA LMPGGVSSPV RAFRSVGGQP LVFDRVKGPY    50
AWDVDGNKYI DYIGSWGPAI CGHAHPEVIS ALQEAIEKGT SFGAPCALEN 100
TLAEMVIDAV PSVEMVRFVN SGTEACMAVL RLMRAFTGRD KVIKFEGCYH 150
GHADMFLVKA GSGVATLGLP DSPGVPRSTT ANTLTAPYND LEAVKQLFAE 200
NPDAISGVIL EPIVGNAGFI QPEPGFLEGL RELTKEHGAL LVFDEVMTGF 250
RISYGGAQAH FGVTPDLTTM GKVIGGGLPV GAYGGRRDIM EMVAPAGPMY 300
QAGTLSGNPL AMTAGIKTLE LLRQPGTYEK LTATTEKLIA GIKEAASAAG 350
LPITGGSVSA MFGFFLCEGP VRNFEEAKAT DAERFGKLHR AMLQRGVYLA 400
PSAFEAGFTS LAHSDGDIEA TLQAFRESFA EIA 433
Length:433
Mass (Da):45,676
Last modified:June 12, 2007 - v1
Checksum:iDD321802CA0AD14D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT971583 Genomic DNA. Translation: CAK24247.1.
RefSeqiWP_011933719.1. NC_009481.1.
YP_001225544.1. NC_009481.1.

Genome annotation databases

EnsemblBacteriaiCAK24247; CAK24247; SynWH7803_1821.
GeneIDi5145974.
KEGGisyx:SynWH7803_1821.
PATRICi23829831. VBISynSp43824_1866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT971583 Genomic DNA. Translation: CAK24247.1 .
RefSeqi WP_011933719.1. NC_009481.1.
YP_001225544.1. NC_009481.1.

3D structure databases

ProteinModelPortali A5GMT2.
SMRi A5GMT2. Positions 6-426.
ModBasei Search...

Protein-protein interaction databases

STRINGi 32051.SynWH7803_1821.

Proteomic databases

PRIDEi A5GMT2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK24247 ; CAK24247 ; SynWH7803_1821 .
GeneIDi 5145974.
KEGGi syx:SynWH7803_1821.
PATRICi 23829831. VBISynSp43824_1866.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi VATHTIT.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
UPA00668 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Genoscope
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH7803.

Entry informationi

Entry nameiGSA_SYNPW
AccessioniPrimary (citable) accession number: A5GMT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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