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A5GM50 (A5GM50_SYNPW) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897
Gene names
Name:gyrA HAMAP MF_01897 EMBL CAK24015.1
Ordered Locus Names:SynWH7803_1589
OrganismSynechococcus sp. (strain WH7803) [Complete proteome] [HAMAP]
Taxonomic identifier32051 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length878 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897

Subcellular location

Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Sequences

Sequence LengthMass (Da)Tools
A5GM50 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: B9150002B0966295

FASTA87896,155
        10         20         30         40         50         60 
MGPGSGGPGD SDDRIIQTDL RNEMSRSYLE YAMSVIVGRA LPDARDGLKP VHRRILYAMY 

        70         80         90        100        110        120 
ELGLTSDRPY RKCARVVGEV LGKYHPHGDT AVYDALVRMA QDFSMSMPLI DGHGNFGSVD 

       130        140        150        160        170        180 
NDPPAAMRYT ESRLKALTTD SLLEDIEAET VDYVDNFDGS QQEPTVLPSR IPQLLLNGSA 

       190        200        210        220        230        240 
GIAVGMATNI PPHNLGELIA GLLALIENPE LSDQELMALI PGPDFPTGGQ ILGRTGIKET 

       250        260        270        280        290        300 
YLSGRGSVTM RGVAAIETLE VPGRPDRDAV IITALPYQTN KAAMIERIAE MVNDKKLEGI 

       310        320        330        340        350        360 
SDIRDESDRD GMRIVVELRR DAYPQVVLNN LYKLTPLQSN FSAHMLALVN GEPILLTLRK 

       370        380        390        400        410        420 
MLEVFLDFRV ETIERRTRYF LRKAEERDHI LLGLLLALDQ LDPIIALIRA APDTATARQQ 

       430        440        450        460        470        480 
LQERHGLSDV QADAILQMQL RRLTALEADK IRLEHEDLVV KIADYKDILG RRERVFGIIQ 

       490        500        510        520        530        540 
DELGQLRDRH AIPRRTEILD LGGGLDDIDL IANERSVVLL TETGYLKRMP VSEFEATSRG 

       550        560        570        580        590        600 
TRGKAGTRSQ GEEAVKLFIG CNDHDTLLLF SDRGVSYALP AYRVPQCSRT AKGTPVVQLL 

       610        620        630        640        650        660 
PIPREEMITS LLAVSEFNDD TDLLMLTQGG FIKRTRLSAF SNIRSNGLIA IGLEEGDALT 

       670        680        690        700        710        720 
WVRLAVPGDS VLIGSRAGMT IHFRLSDDEL RPLGRTARGV RSMNLRDGDA LVSMDVLPVE 

       730        740        750        760        770        780 
LADRVAQSSE DDSGEDETGD VSDGPWVLVA SASGLGKRVP VTQFRLQKRA GMGLRAMKFR 

       790        800        810        820        830        840 
TEADALVGLR VLGAGEEVLL VSEKGVIVRT SADSIPQQSR AATGVRLQRL DKGDRLSEVV 

       850        860        870 
LVPPEAESDE EEADAEASDA PVVGADSNAA EPSSDQDS

« Hide

References

[1]Genoscope
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CT971583 Genomic DNA. Translation: CAK24015.1.
RefSeqYP_001225312.1. NC_009481.1.

3D structure databases

ProteinModelPortalA5GM50.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5GM50.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5147696.
GenomeReviewsGene locus SynWH7803_1589 in contig CT971583_GR.
KEGGsyx:SynWH7803_1589.
PATRIC23829336. VBISynSp43824_1624.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHBG635183.
OMATSIPPHR.
PhylomeDBA5GM50.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycSSP32051:SYNWH7803_1589-MONOMER.

Family and domain databases

HAMAPMF_01897. GyrA.
[Tree]
InterProIPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KOK02469.
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. GyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA5GM50_SYNPW
AccessionPrimary (citable) accession number: A5GM50
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info