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A5GLK1

- CPDA_SYNPW

UniProt

A5GLK1 - CPDA_SYNPW

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi9 – 91Metal cation 1UniRule annotation
    Metal bindingi11 – 111Metal cation 1UniRule annotation
    Binding sitei11 – 111cAMPUniRule annotation
    Metal bindingi49 – 491Metal cation 1UniRule annotation
    Metal bindingi49 – 491Metal cation 2UniRule annotation
    Binding sitei49 – 491cAMPUniRule annotation
    Metal bindingi86 – 861Metal cation 2UniRule annotation
    Metal bindingi157 – 1571Metal cation 2UniRule annotation
    Metal bindingi196 – 1961Metal cation 2UniRule annotation
    Metal bindingi198 – 1981Metal cation 1UniRule annotation
    Binding sitei198 – 1981cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi86 – 872cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:SynWH7803_1390
    OrganismiSynechococcus sp. (strain WH7803)
    Taxonomic identifieri32051 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001566: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2652653',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413380Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi32051.SynWH7803_1390.

    Structurei

    3D structure databases

    ProteinModelPortaliA5GLK1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000238351.
    KOiK03651.
    OMAiTERTLLW.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5GLK1-1 [UniParc]FASTAAdd to Basket

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    MPRLIQLSDP HLVARAEGRV RGRSALSLFQ KALAQALQEQ PDLLLVTGDC    50
    CHDETWCGYV RLRDAVDAAI QQQAARTVCL GFTAGNHDHP QRLRAVLGRH 100
    WVVAPGVMDA GCWRLLVVSS HRAGGCAGVI GGVQLSWLNT QLREAETLGK 150
    FVVVALHHPP VPIGDASMDT IGLSDGEQLM DSLKRWPAVR VVLFGHIHQH 200
    WKGMAAPRSD LSLLGCPSTL VSFHPVQPCP LGRAWDPGGR LLDLMEDGSV 250
    QERLMRWSAC EQAAG 265
    Length:265
    Mass (Da):28,853
    Last modified:June 12, 2007 - v1
    Checksum:i7FE6607A21BB317B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT971583 Genomic DNA. Translation: CAK23816.1.
    RefSeqiWP_011933294.1. NC_009481.1.
    YP_001225113.1. NC_009481.1.

    Genome annotation databases

    EnsemblBacteriaiCAK23816; CAK23816; SynWH7803_1390.
    GeneIDi5148198.
    KEGGisyx:SynWH7803_1390.
    PATRICi23828928. VBISynSp43824_1423.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT971583 Genomic DNA. Translation: CAK23816.1 .
    RefSeqi WP_011933294.1. NC_009481.1.
    YP_001225113.1. NC_009481.1.

    3D structure databases

    ProteinModelPortali A5GLK1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 32051.SynWH7803_1390.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK23816 ; CAK23816 ; SynWH7803_1390 .
    GeneIDi 5148198.
    KEGGi syx:SynWH7803_1390.
    PATRICi 23828928. VBISynSp43824_1423.

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000238351.
    KOi K03651.
    OMAi TERTLLW.
    OrthoDBi EOG6QG8GQ.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Genoscope
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH7803.

    Entry informationi

    Entry nameiCPDA_SYNPW
    AccessioniPrimary (citable) accession number: A5GLK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3