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A5GLK1 (CPDA_SYNPW) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Short name=3',5'-cyclic AMP phosphodiesterase
Short name=cAMP phosphodiesterase
EC=3.1.4.17
Gene names
Name:cpdA
Ordered Locus Names:SynWH7803_1390
OrganismSynechococcus sp. (strain WH7803) [Complete proteome] [HAMAP]
Taxonomic identifier32051 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity. HAMAP-Rule MF_00905

Catalytic activity

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. HAMAP-Rule MF_00905

Cofactor

Binds 2 metal cations per subunit By similarity.

Sequence similarities

Belongs to the cAMP phosphodiesterase class-III family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2652653',5'-cyclic adenosine monophosphate phosphodiesterase CpdA HAMAP-Rule MF_00905
PRO_0000413380

Regions

Nucleotide binding86 – 872cAMP By similarity

Sites

Metal binding91Metal cation 1 By similarity
Metal binding111Metal cation 1 By similarity
Metal binding491Metal cation 1 By similarity
Metal binding491Metal cation 2 By similarity
Metal binding861Metal cation 2 By similarity
Metal binding1571Metal cation 2 By similarity
Metal binding1961Metal cation 2 By similarity
Metal binding1981Metal cation 1 By similarity
Binding site111cAMP By similarity
Binding site491cAMP By similarity
Binding site1981cAMP By similarity

Sequences

Sequence LengthMass (Da)Tools
A5GLK1 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 7FE6607A21BB317B

FASTA26528,853
        10         20         30         40         50         60 
MPRLIQLSDP HLVARAEGRV RGRSALSLFQ KALAQALQEQ PDLLLVTGDC CHDETWCGYV 

        70         80         90        100        110        120 
RLRDAVDAAI QQQAARTVCL GFTAGNHDHP QRLRAVLGRH WVVAPGVMDA GCWRLLVVSS 

       130        140        150        160        170        180 
HRAGGCAGVI GGVQLSWLNT QLREAETLGK FVVVALHHPP VPIGDASMDT IGLSDGEQLM 

       190        200        210        220        230        240 
DSLKRWPAVR VVLFGHIHQH WKGMAAPRSD LSLLGCPSTL VSFHPVQPCP LGRAWDPGGR 

       250        260 
LLDLMEDGSV QERLMRWSAC EQAAG

« Hide

References

[1]Genoscope
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WH7803.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CT971583 Genomic DNA. Translation: CAK23816.1.
RefSeqYP_001225113.1. NC_009481.1.

3D structure databases

ProteinModelPortalA5GLK1.
ModBaseSearch...

Protein-protein interaction databases

STRING32051.SynWH7803_1390.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAK23816; CAK23816; SynWH7803_1390.
GeneID5148198.
KEGGsyx:SynWH7803_1390.
PATRIC23828928. VBISynSp43824_1423.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1409.
HOGENOMHOG000238351.
KOK03651.
OMAIANDRSE.
ProtClustDBCLSK826164.

Family and domain databases

HAMAPMF_00905. cAMP_phophodiest_CpdA.
InterProIPR026575. cAMP_Pdiest_CpdA.
IPR004843. Metallo_PEstase_dom.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCPDA_SYNPW
AccessionPrimary (citable) accession number: A5GLK1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: June 12, 2007
Last modified: May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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