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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Metal cation 1UniRule annotation1
Metal bindingi11Metal cation 1UniRule annotation1
Binding sitei11cAMPUniRule annotation1
Metal bindingi49Metal cation 1UniRule annotation1
Metal bindingi49Metal cation 2UniRule annotation1
Binding sitei49cAMPUniRule annotation1
Metal bindingi86Metal cation 2UniRule annotation1
Metal bindingi157Metal cation 2UniRule annotation1
Metal bindingi196Metal cation 2UniRule annotation1
Metal bindingi198Metal cation 1UniRule annotation1
Binding sitei198cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi86 – 87cAMPUniRule annotation2

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP32051:G1GJK-1378-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:SynWH7803_1390
OrganismiSynechococcus sp. (strain WH7803)
Taxonomic identifieri32051 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001566 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133801 – 2653',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST265

Interactioni

Protein-protein interaction databases

STRINGi32051.SynWH7803_1390

Structurei

3D structure databases

ProteinModelPortaliA5GLK1
SMRiA5GLK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41070EG Bacteria
COG1409 LUCA
HOGENOMiHOG000238351
KOiK03651
OMAiCAWLDQH
OrthoDBiPOG091H05L5

Family and domain databases

Gene3Di3.60.21.10, 1 hit
HAMAPiMF_00905 cAMP_phophodiest_CpdA, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR026575 cAMP_Pdiest_CpdA
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit

Sequencei

Sequence statusi: Complete.

A5GLK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLIQLSDP HLVARAEGRV RGRSALSLFQ KALAQALQEQ PDLLLVTGDC
60 70 80 90 100
CHDETWCGYV RLRDAVDAAI QQQAARTVCL GFTAGNHDHP QRLRAVLGRH
110 120 130 140 150
WVVAPGVMDA GCWRLLVVSS HRAGGCAGVI GGVQLSWLNT QLREAETLGK
160 170 180 190 200
FVVVALHHPP VPIGDASMDT IGLSDGEQLM DSLKRWPAVR VVLFGHIHQH
210 220 230 240 250
WKGMAAPRSD LSLLGCPSTL VSFHPVQPCP LGRAWDPGGR LLDLMEDGSV
260
QERLMRWSAC EQAAG
Length:265
Mass (Da):28,853
Last modified:June 12, 2007 - v1
Checksum:i7FE6607A21BB317B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT971583 Genomic DNA Translation: CAK23816.1
RefSeqiWP_011933294.1, NC_009481.1

Genome annotation databases

EnsemblBacteriaiCAK23816; CAK23816; SynWH7803_1390
KEGGisyx:SynWH7803_1390

Similar proteinsi

Entry informationi

Entry nameiCPDA_SYNPW
AccessioniPrimary (citable) accession number: A5GLK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: June 12, 2007
Last modified: March 28, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health