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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Metal cation 1UniRule annotation
Metal bindingi11 – 111Metal cation 1UniRule annotation
Binding sitei11 – 111cAMPUniRule annotation
Metal bindingi49 – 491Metal cation 1UniRule annotation
Metal bindingi49 – 491Metal cation 2UniRule annotation
Binding sitei49 – 491cAMPUniRule annotation
Metal bindingi86 – 861Metal cation 2UniRule annotation
Metal bindingi157 – 1571Metal cation 2UniRule annotation
Metal bindingi196 – 1961Metal cation 2UniRule annotation
Metal bindingi198 – 1981Metal cation 1UniRule annotation
Binding sitei198 – 1981cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi86 – 872cAMPUniRule annotation

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:SynWH7803_1390
OrganismiSynechococcus sp. (strain WH7803)
Taxonomic identifieri32051 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001566 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2652653',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413380Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi32051.SynWH7803_1390.

Structurei

3D structure databases

ProteinModelPortaliA5GLK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000238351.
KOiK03651.
OMAiPVQPCPL.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

A5GLK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLIQLSDP HLVARAEGRV RGRSALSLFQ KALAQALQEQ PDLLLVTGDC
60 70 80 90 100
CHDETWCGYV RLRDAVDAAI QQQAARTVCL GFTAGNHDHP QRLRAVLGRH
110 120 130 140 150
WVVAPGVMDA GCWRLLVVSS HRAGGCAGVI GGVQLSWLNT QLREAETLGK
160 170 180 190 200
FVVVALHHPP VPIGDASMDT IGLSDGEQLM DSLKRWPAVR VVLFGHIHQH
210 220 230 240 250
WKGMAAPRSD LSLLGCPSTL VSFHPVQPCP LGRAWDPGGR LLDLMEDGSV
260
QERLMRWSAC EQAAG
Length:265
Mass (Da):28,853
Last modified:June 12, 2007 - v1
Checksum:i7FE6607A21BB317B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT971583 Genomic DNA. Translation: CAK23816.1.
RefSeqiWP_011933294.1. NC_009481.1.
YP_001225113.1. NC_009481.1.

Genome annotation databases

EnsemblBacteriaiCAK23816; CAK23816; SynWH7803_1390.
KEGGisyx:SynWH7803_1390.
PATRICi23828928. VBISynSp43824_1423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT971583 Genomic DNA. Translation: CAK23816.1.
RefSeqiWP_011933294.1. NC_009481.1.
YP_001225113.1. NC_009481.1.

3D structure databases

ProteinModelPortaliA5GLK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi32051.SynWH7803_1390.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAK23816; CAK23816; SynWH7803_1390.
KEGGisyx:SynWH7803_1390.
PATRICi23828928. VBISynSp43824_1423.

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000238351.
KOiK03651.
OMAiPVQPCPL.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Genoscope
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH7803.

Entry informationi

Entry nameiCPDA_SYNPW
AccessioniPrimary (citable) accession number: A5GLK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: June 12, 2007
Last modified: April 1, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.