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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Metal cation 1UniRule annotation1
Metal bindingi11Metal cation 1UniRule annotation1
Binding sitei11cAMPUniRule annotation1
Metal bindingi49Metal cation 1UniRule annotation1
Metal bindingi49Metal cation 2UniRule annotation1
Binding sitei49cAMPUniRule annotation1
Metal bindingi86Metal cation 2UniRule annotation1
Metal bindingi157Metal cation 2UniRule annotation1
Metal bindingi196Metal cation 2UniRule annotation1
Metal bindingi198Metal cation 1UniRule annotation1
Binding sitei198cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi86 – 87cAMPUniRule annotation2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:SynWH7803_1390
OrganismiSynechococcus sp. (strain WH7803)
Taxonomic identifieri32051 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001566 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133801 – 2653',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST265

Interactioni

Protein-protein interaction databases

STRINGi32051.SynWH7803_1390.

Structurei

3D structure databases

ProteinModelPortaliA5GLK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.
HOGENOMiHOG000238351.
KOiK03651.
OMAiFGHIHQH.
OrthoDBiPOG091H05L5.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

A5GLK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLIQLSDP HLVARAEGRV RGRSALSLFQ KALAQALQEQ PDLLLVTGDC
60 70 80 90 100
CHDETWCGYV RLRDAVDAAI QQQAARTVCL GFTAGNHDHP QRLRAVLGRH
110 120 130 140 150
WVVAPGVMDA GCWRLLVVSS HRAGGCAGVI GGVQLSWLNT QLREAETLGK
160 170 180 190 200
FVVVALHHPP VPIGDASMDT IGLSDGEQLM DSLKRWPAVR VVLFGHIHQH
210 220 230 240 250
WKGMAAPRSD LSLLGCPSTL VSFHPVQPCP LGRAWDPGGR LLDLMEDGSV
260
QERLMRWSAC EQAAG
Length:265
Mass (Da):28,853
Last modified:June 12, 2007 - v1
Checksum:i7FE6607A21BB317B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT971583 Genomic DNA. Translation: CAK23816.1.
RefSeqiWP_011933294.1. NC_009481.1.

Genome annotation databases

EnsemblBacteriaiCAK23816; CAK23816; SynWH7803_1390.
KEGGisyx:SynWH7803_1390.
PATRICi23828928. VBISynSp43824_1423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT971583 Genomic DNA. Translation: CAK23816.1.
RefSeqiWP_011933294.1. NC_009481.1.

3D structure databases

ProteinModelPortaliA5GLK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi32051.SynWH7803_1390.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAK23816; CAK23816; SynWH7803_1390.
KEGGisyx:SynWH7803_1390.
PATRICi23828928. VBISynSp43824_1423.

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.
HOGENOMiHOG000238351.
KOiK03651.
OMAiFGHIHQH.
OrthoDBiPOG091H05L5.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPDA_SYNPW
AccessioniPrimary (citable) accession number: A5GLK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: June 12, 2007
Last modified: November 30, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.