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A5GL71

- SYL_SYNPW

UniProt

A5GL71 - SYL_SYNPW

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Protein
Leucine--tRNA ligase
Gene
leuS, SynWH7803_1260
Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei635 – 6351ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:SynWH7803_1260
OrganismiSynechococcus sp. (strain WH7803)
Taxonomic identifieri32051 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001566: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878878Leucine--tRNA ligaseUniRule annotation
PRO_0000334832Add
BLAST

Proteomic databases

PRIDEiA5GL71.

Interactioni

Protein-protein interaction databases

STRINGi32051.SynWH7803_1260.

Structurei

3D structure databases

ProteinModelPortaliA5GL71.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi58 – 6811"HIGH" regionUniRule annotation
Add
BLAST
Motifi632 – 6365"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVHRQSWP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5GL71-1 [UniParc]FASTAAdd to Basket

« Hide

MTASKSSSAT ASASDRPDRY DPIALEQRWQ SQWQQDDLYA TRSPEPGQNA    50
FYALSMFPYP SGSLHMGHVR NYVITDVIAR AQRMRGDSVL HPMGWDAFGL 100
PAENAAIERQ VDPGVWTDRN IEQMKAQLAR LGLSIDWSRE QATCHADYYR 150
WTQWLFLELM DQGLAYQKDA TVNWDPVDQT VLANEQVDSE GRSWRSGALV 200
EQKNLRQWFL RITNYADALL DDLDLLKGWP ERVRTMQANW IGRSIGAEID 250
FRVSDHDDAV ITVFTTRADT LHGVSYVVLA PEHPLVATLT AEHQRESVAA 300
FRDLVGELSA DERTADDRPK RGVPIGATAV NPANGESIPI WIADYVLAGY 350
GTGAVMGVPA HDERDFLFAR TYELPVKRVI QAAGTSDHLS DGEAWTGPGI 400
LLNSGRFDGQ SSEEARQEIT AHGQELGWAR PKRQYRLRDW LISRQRYWGC 450
PIPVIHCDHC GAVPVPADQL PVTLPKDVDL QGKGGSPLAS LQSWVNVKCP 500
SCGRDARRET DTMDTFMCSS WYFLRFADPH NTERAFDADA VERWLPVQQY 550
VGGIEHAILH LLYSRFFTKA LRDRGLLNIR EPFERLLTQG MVQGVTYRNP 600
RTGRYVAPSE VSDENAPKDP VDGGELEVLF EKMSKSKYNG VDPAAVIDRY 650
GADTARMFIL FKAPPEKDLE WDDADVEGQF RFLQRLWRLI ESVRSDDQDQ 700
LLGDPVDPPE GSGLSDKEGE IRRAVHTAIE AVSDDLKGDF QFNTAISELM 750
KLSNTLSGAL PEASRAVQAE AVSALIRLLA PFAPHLAEEF WFSLGGQDSV 800
HKQPWPLHDP AALVRDTVDL VIQVKGKVRG TITVPADCSK ETLEELALAS 850
DVAERWLEGK PPRRVIVVPG KLVNLVPS 878
Length:878
Mass (Da):98,170
Last modified:June 12, 2007 - v1
Checksum:i26816D443AA013D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT971583 Genomic DNA. Translation: CAK23686.1.
RefSeqiWP_011933166.1. NC_009481.1.
YP_001224983.1. NC_009481.1.

Genome annotation databases

EnsemblBacteriaiCAK23686; CAK23686; SynWH7803_1260.
GeneIDi5146257.
KEGGisyx:SynWH7803_1260.
PATRICi23828664. VBISynSp43824_1293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT971583 Genomic DNA. Translation: CAK23686.1 .
RefSeqi WP_011933166.1. NC_009481.1.
YP_001224983.1. NC_009481.1.

3D structure databases

ProteinModelPortali A5GL71.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 32051.SynWH7803_1260.

Proteomic databases

PRIDEi A5GL71.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK23686 ; CAK23686 ; SynWH7803_1260 .
GeneIDi 5146257.
KEGGi syx:SynWH7803_1260.
PATRICi 23828664. VBISynSp43824_1293.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VHRQSWP.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Genoscope
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH7803.

Entry informationi

Entry nameiSYL_SYNPW
AccessioniPrimary (citable) accession number: A5GL71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi