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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei635 – 6351ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:SynWH7803_1260
OrganismiSynechococcus sp. (strain WH7803)
Taxonomic identifieri32051 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001566 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878878Leucine--tRNA ligasePRO_0000334832Add
BLAST

Proteomic databases

PRIDEiA5GL71.

Interactioni

Protein-protein interaction databases

STRINGi32051.SynWH7803_1260.

Structurei

3D structure databases

ProteinModelPortaliA5GL71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi58 – 6811"HIGH" regionAdd
BLAST
Motifi632 – 6365"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5GL71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASKSSSAT ASASDRPDRY DPIALEQRWQ SQWQQDDLYA TRSPEPGQNA
60 70 80 90 100
FYALSMFPYP SGSLHMGHVR NYVITDVIAR AQRMRGDSVL HPMGWDAFGL
110 120 130 140 150
PAENAAIERQ VDPGVWTDRN IEQMKAQLAR LGLSIDWSRE QATCHADYYR
160 170 180 190 200
WTQWLFLELM DQGLAYQKDA TVNWDPVDQT VLANEQVDSE GRSWRSGALV
210 220 230 240 250
EQKNLRQWFL RITNYADALL DDLDLLKGWP ERVRTMQANW IGRSIGAEID
260 270 280 290 300
FRVSDHDDAV ITVFTTRADT LHGVSYVVLA PEHPLVATLT AEHQRESVAA
310 320 330 340 350
FRDLVGELSA DERTADDRPK RGVPIGATAV NPANGESIPI WIADYVLAGY
360 370 380 390 400
GTGAVMGVPA HDERDFLFAR TYELPVKRVI QAAGTSDHLS DGEAWTGPGI
410 420 430 440 450
LLNSGRFDGQ SSEEARQEIT AHGQELGWAR PKRQYRLRDW LISRQRYWGC
460 470 480 490 500
PIPVIHCDHC GAVPVPADQL PVTLPKDVDL QGKGGSPLAS LQSWVNVKCP
510 520 530 540 550
SCGRDARRET DTMDTFMCSS WYFLRFADPH NTERAFDADA VERWLPVQQY
560 570 580 590 600
VGGIEHAILH LLYSRFFTKA LRDRGLLNIR EPFERLLTQG MVQGVTYRNP
610 620 630 640 650
RTGRYVAPSE VSDENAPKDP VDGGELEVLF EKMSKSKYNG VDPAAVIDRY
660 670 680 690 700
GADTARMFIL FKAPPEKDLE WDDADVEGQF RFLQRLWRLI ESVRSDDQDQ
710 720 730 740 750
LLGDPVDPPE GSGLSDKEGE IRRAVHTAIE AVSDDLKGDF QFNTAISELM
760 770 780 790 800
KLSNTLSGAL PEASRAVQAE AVSALIRLLA PFAPHLAEEF WFSLGGQDSV
810 820 830 840 850
HKQPWPLHDP AALVRDTVDL VIQVKGKVRG TITVPADCSK ETLEELALAS
860 870
DVAERWLEGK PPRRVIVVPG KLVNLVPS
Length:878
Mass (Da):98,170
Last modified:June 11, 2007 - v1
Checksum:i26816D443AA013D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT971583 Genomic DNA. Translation: CAK23686.1.
RefSeqiWP_011933166.1. NC_009481.1.
YP_001224983.1. NC_009481.1.

Genome annotation databases

EnsemblBacteriaiCAK23686; CAK23686; SynWH7803_1260.
KEGGisyx:SynWH7803_1260.
PATRICi23828664. VBISynSp43824_1293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT971583 Genomic DNA. Translation: CAK23686.1.
RefSeqiWP_011933166.1. NC_009481.1.
YP_001224983.1. NC_009481.1.

3D structure databases

ProteinModelPortaliA5GL71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi32051.SynWH7803_1260.

Proteomic databases

PRIDEiA5GL71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAK23686; CAK23686; SynWH7803_1260.
KEGGisyx:SynWH7803_1260.
PATRICi23828664. VBISynSp43824_1293.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Genoscope
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH7803.

Entry informationi

Entry nameiSYL_SYNPW
AccessioniPrimary (citable) accession number: A5GL71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 19, 2008
Last sequence update: June 11, 2007
Last modified: March 31, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.