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A5GL71

- SYL_SYNPW

UniProt

A5GL71 - SYL_SYNPW

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei635 – 6351ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:SynWH7803_1260
    OrganismiSynechococcus sp. (strain WH7803)
    Taxonomic identifieri32051 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001566: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 878878Leucine--tRNA ligasePRO_0000334832Add
    BLAST

    Proteomic databases

    PRIDEiA5GL71.

    Interactioni

    Protein-protein interaction databases

    STRINGi32051.SynWH7803_1260.

    Structurei

    3D structure databases

    ProteinModelPortaliA5GL71.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi58 – 6811"HIGH" regionAdd
    BLAST
    Motifi632 – 6365"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiVHRQSWP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5GL71-1 [UniParc]FASTAAdd to Basket

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    MTASKSSSAT ASASDRPDRY DPIALEQRWQ SQWQQDDLYA TRSPEPGQNA    50
    FYALSMFPYP SGSLHMGHVR NYVITDVIAR AQRMRGDSVL HPMGWDAFGL 100
    PAENAAIERQ VDPGVWTDRN IEQMKAQLAR LGLSIDWSRE QATCHADYYR 150
    WTQWLFLELM DQGLAYQKDA TVNWDPVDQT VLANEQVDSE GRSWRSGALV 200
    EQKNLRQWFL RITNYADALL DDLDLLKGWP ERVRTMQANW IGRSIGAEID 250
    FRVSDHDDAV ITVFTTRADT LHGVSYVVLA PEHPLVATLT AEHQRESVAA 300
    FRDLVGELSA DERTADDRPK RGVPIGATAV NPANGESIPI WIADYVLAGY 350
    GTGAVMGVPA HDERDFLFAR TYELPVKRVI QAAGTSDHLS DGEAWTGPGI 400
    LLNSGRFDGQ SSEEARQEIT AHGQELGWAR PKRQYRLRDW LISRQRYWGC 450
    PIPVIHCDHC GAVPVPADQL PVTLPKDVDL QGKGGSPLAS LQSWVNVKCP 500
    SCGRDARRET DTMDTFMCSS WYFLRFADPH NTERAFDADA VERWLPVQQY 550
    VGGIEHAILH LLYSRFFTKA LRDRGLLNIR EPFERLLTQG MVQGVTYRNP 600
    RTGRYVAPSE VSDENAPKDP VDGGELEVLF EKMSKSKYNG VDPAAVIDRY 650
    GADTARMFIL FKAPPEKDLE WDDADVEGQF RFLQRLWRLI ESVRSDDQDQ 700
    LLGDPVDPPE GSGLSDKEGE IRRAVHTAIE AVSDDLKGDF QFNTAISELM 750
    KLSNTLSGAL PEASRAVQAE AVSALIRLLA PFAPHLAEEF WFSLGGQDSV 800
    HKQPWPLHDP AALVRDTVDL VIQVKGKVRG TITVPADCSK ETLEELALAS 850
    DVAERWLEGK PPRRVIVVPG KLVNLVPS 878
    Length:878
    Mass (Da):98,170
    Last modified:June 12, 2007 - v1
    Checksum:i26816D443AA013D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT971583 Genomic DNA. Translation: CAK23686.1.
    RefSeqiWP_011933166.1. NC_009481.1.
    YP_001224983.1. NC_009481.1.

    Genome annotation databases

    EnsemblBacteriaiCAK23686; CAK23686; SynWH7803_1260.
    GeneIDi5146257.
    KEGGisyx:SynWH7803_1260.
    PATRICi23828664. VBISynSp43824_1293.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT971583 Genomic DNA. Translation: CAK23686.1 .
    RefSeqi WP_011933166.1. NC_009481.1.
    YP_001224983.1. NC_009481.1.

    3D structure databases

    ProteinModelPortali A5GL71.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 32051.SynWH7803_1260.

    Proteomic databases

    PRIDEi A5GL71.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK23686 ; CAK23686 ; SynWH7803_1260 .
    GeneIDi 5146257.
    KEGGi syx:SynWH7803_1260.
    PATRICi 23828664. VBISynSp43824_1293.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi VHRQSWP.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Genoscope
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH7803.

    Entry informationi

    Entry nameiSYL_SYNPW
    AccessioniPrimary (citable) accession number: A5GL71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3