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Protein

Catalase-peroxidase

Gene

katG

Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei92Transition state stabilizerUniRule annotation1
Active sitei96Proton acceptorUniRule annotation1
Metal bindingi259Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei6246. SspCP01_WH7803.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:SynWH7803_0792
OrganismiSynechococcus sp. (strain WH7803)
Taxonomic identifieri32051 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001566 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003549451 – 731Catalase-peroxidaseAdd BLAST731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki95 ↔ 218Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-244)UniRule annotation
Cross-linki218 ↔ 244Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA5GJV3.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi32051.SynWH7803_0792.

Structurei

3D structure databases

ProteinModelPortaliA5GJV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5GJV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLKCPFSG HTGAVTPAGN TNNGDWWPNQ INLGILHQHH PASNPLGDAF
60 70 80 90 100
DYPTAFASLD YSALKADLQT LMTDSQDWWP ADWGHYGALF IRLAWHSAGT
110 120 130 140 150
YRTGDGRGGA GHGNQRFAPL NSWPDNTNLD KARRLLWPIK RKYGNAISWA
160 170 180 190 200
DLIILSGNVA LESMGFRTFG FAGGREDIWQ PEEDVFWGKE TGWLKDERRN
210 220 230 240 250
DKGELNQPLA AVEMGLIYVN PEGPHGEPDP VASGRDVRET FARMGMTVEE
260 270 280 290 300
TVALVAGGHT FGKCHGAAPD SHLEAEPEGA ALHEQGLGWR NTYESGKGEH
310 320 330 340 350
TITSGIEGAW KPNPTRWDQG YFQMMFTYEW ELTKSPAGAW QWTAKDVKPE
360 370 380 390 400
HMIPDAHVAG KSSAPIMTTA DLSLRHDAIM EPVARRFHLD QEAFADAFAR
410 420 430 440 450
AWFKLTHRDL GPRALYLGPD VPEEVQIWQD PVPPVTHPLI DEAEISTLKQ
460 470 480 490 500
QILASGQSVS ALVAAAWGSA STFRGSDRRG GANGGRIRLL PQRTWEVNDP
510 520 530 540 550
EQLNGVLTAL ETIQSQFNSS SSNGKSVSIA DLIVLGGCAA VEKAAADGGH
560 570 580 590 600
TVVVPFRPGR SDAGPEQTDT ASFNVLKPLA DGFRNWQRSG LPLRAEELLV
610 620 630 640 650
DRAQLLTLSA PEMTVLLAGL RVMGANTAGN RQGVFTQNVG VLSNDFCVNL
660 670 680 690 700
LDMTTRWTPT SEAQDAYIGR DSATGAERWS ASRADLVFGS NSQLRAIVEV
710 720 730
YAQNDGGSRF VADFVKAWVK VMELDRFDLR S
Length:731
Mass (Da):79,962
Last modified:June 12, 2007 - v1
Checksum:i7F170F1D7523A733
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT971583 Genomic DNA. Translation: CAK23218.1.
RefSeqiWP_011932700.1. NC_009481.1.

Genome annotation databases

EnsemblBacteriaiCAK23218; CAK23218; SynWH7803_0792.
KEGGisyx:SynWH7803_0792.
PATRICi23827693. VBISynSp43824_0811.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT971583 Genomic DNA. Translation: CAK23218.1.
RefSeqiWP_011932700.1. NC_009481.1.

3D structure databases

ProteinModelPortaliA5GJV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi32051.SynWH7803_0792.

Protein family/group databases

PeroxiBasei6246. SspCP01_WH7803.

Proteomic databases

PRIDEiA5GJV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAK23218; CAK23218; SynWH7803_0792.
KEGGisyx:SynWH7803_0792.
PATRICi23827693. VBISynSp43824_0811.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_SYNPW
AccessioniPrimary (citable) accession number: A5GJV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: June 12, 2007
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.