A5GJV3 (KATG_SYNPW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Catalase-peroxidase
Short name=CP
EC=1.11.1.21

Alternative name(s):
Peroxidase/catalase

Gene names

Name:	katG
Ordered Locus Names:	SynWH7803_0792

Organism

Synechococcus sp. (strain WH7803) [Complete proteome] [HAMAP]

Taxonomic identifier

32051 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	731 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity By similarity. HAMAP MF_01961
Catalytic activity	Donor + H2O2 = oxidized donor + 2 H2O. HAMAP MF_01961 2 H2O2 = O2 + 2 H2O. HAMAP MF_01961
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity.
Subunit structure	Homodimer or homotetramer By similarity. HAMAP MF_01961
Post-translational modification	The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme By similarity. HAMAP MF_01961
Sequence similarities	Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalase activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 731	731	Catalase-peroxidase HAMAP MF_01961		PRO_0000354945
Sites
	Active site	96	1	Proton acceptor By similarity
	Metal binding	259	1	Iron (heme axial ligand) By similarity
	Site	92	1	Transition state stabilizer By similarity
Amino acid modifications
	Cross-link	95 ↔ 218		Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-244) By similarity
	Cross-link	218 ↔ 244		Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95) By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5GJV3 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 7F170F1D7523A733	FASTA	731	79,962
	10 20 30 40 50 60 MSDLKCPFSG HTGAVTPAGN TNNGDWWPNQ INLGILHQHH PASNPLGDAF DYPTAFASLD 70 80 90 100 110 120 YSALKADLQT LMTDSQDWWP ADWGHYGALF IRLAWHSAGT YRTGDGRGGA GHGNQRFAPL 130 140 150 160 170 180 NSWPDNTNLD KARRLLWPIK RKYGNAISWA DLIILSGNVA LESMGFRTFG FAGGREDIWQ 190 200 210 220 230 240 PEEDVFWGKE TGWLKDERRN DKGELNQPLA AVEMGLIYVN PEGPHGEPDP VASGRDVRET 250 260 270 280 290 300 FARMGMTVEE TVALVAGGHT FGKCHGAAPD SHLEAEPEGA ALHEQGLGWR NTYESGKGEH 310 320 330 340 350 360 TITSGIEGAW KPNPTRWDQG YFQMMFTYEW ELTKSPAGAW QWTAKDVKPE HMIPDAHVAG 370 380 390 400 410 420 KSSAPIMTTA DLSLRHDAIM EPVARRFHLD QEAFADAFAR AWFKLTHRDL GPRALYLGPD 430 440 450 460 470 480 VPEEVQIWQD PVPPVTHPLI DEAEISTLKQ QILASGQSVS ALVAAAWGSA STFRGSDRRG 490 500 510 520 530 540 GANGGRIRLL PQRTWEVNDP EQLNGVLTAL ETIQSQFNSS SSNGKSVSIA DLIVLGGCAA 550 560 570 580 590 600 VEKAAADGGH TVVVPFRPGR SDAGPEQTDT ASFNVLKPLA DGFRNWQRSG LPLRAEELLV 610 620 630 640 650 660 DRAQLLTLSA PEMTVLLAGL RVMGANTAGN RQGVFTQNVG VLSNDFCVNL LDMTTRWTPT 670 680 690 700 710 720 SEAQDAYIGR DSATGAERWS ASRADLVFGS NSQLRAIVEV YAQNDGGSRF VADFVKAWVK 730 VMELDRFDLR S

References

[1]	Genoscope Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WH7803.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT971583 Genomic DNA. Translation: CAK23218.1.
RefSeq	YP_001224515.1. NC_009481.1.
3D structure databases
ProteinModelPortal	A5GJV3.
SMR	A5GJV3. Positions 21-729.
ModBase	Search...
Protein-protein interaction databases
STRING	A5GJV3.
Protein family/group databases
PeroxiBase	6246. SspCP01_WH7803.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5147035.
GenomeReviews	Gene locus SynWH7803_0792 in contig CT971583_GR.
KEGG	syx:SynWH7803_0792.
PATRIC	23827693. VBISynSp43824_0811.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0376.
HOGENOM	HBG285610.
OMA	KRHAPSM.
PhylomeDB	A5GJV3.
ProtClustDB	PRK15061.
Family and domain databases
HAMAP	MF_01961. Catal-peroxid. [Tree]
InterPro	IPR000763. Catalase_peroxidase. IPR010255. Haem_peroxidase. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. IPR019793. Peroxidases_heam-ligand_BS. [Graphical view]
KO	K03782.
Pfam	PF00141. peroxidase. 2 hits. [Graphical view]
PRINTS	PR00460. BPEROXIDASE. PR00458. PEROXIDASE.
SUPFAM	SSF48113. Peroxidase_super. 2 hits.
TIGRFAMs	TIGR00198. Cat_per_HPI. 1 hit.
PROSITE	PS00435. PEROXIDASE_1. 1 hit. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KATG_SYNPW

Accession

Primary (citable) accession number: A5GJV3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program