Reviewed,
UniProtKB/Swiss-Prot A5GIY5 (PANCY_SYNPW)
Last modified
November 3, 2009.
Version 16.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Bifunctional pantoate ligase/cytidylate kinase Including the following 2 domains: 1- Recommended name: Pantothenate synthetase Short name=PS EC=6.3.2.1 Alternative name(s): Pantoate--beta-alanine ligase Pantoate-activating enzyme 2- Recommended name: Cytidylate kinase Short name=CK EC=2.7.4.14 Alternative name(s): Cytidine monophosphate kinase Short name=CMP kinase | ||||
| Gene names |
| ||||
| Organism | Synechococcus sp. (strain WH7803) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 32051 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Cyanobacteria › Chroococcales › Synechococcus |
Protein attributes
| Sequence length | 490 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. Displays a CMP kinase activity By similarity. |
| Catalytic activity | ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP MF_01349 ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_01349 |
| Pathway | Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP MF_01349 |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | In the N-terminal section; belongs to the pantothenate synthetase family. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pantothenate biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Ligase Transferase |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | pantothenate biosynthetic process Inferred from electronic annotation. Source: HAMAP pyrimidine nucleotide metabolic processInferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP cytidylate kinase activityInferred from electronic annotation. Source: HAMAP pantoate-beta-alanine ligase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 490 | 490 | Bifunctional pantoate ligase/cytidylate kinase HAMAP MF_01349 | PRO_0000333302 | |||||
Regions | |||||||||
| Nucleotide binding | 1 – 8 | 8 | ATP By similarity | ||||||
| Nucleotide binding | 124 – 127 | 4 | ATP By similarity | ||||||
| Nucleotide binding | 161 – 164 | 4 | ATP By similarity | ||||||
| Region | 1 – 253 | 253 | Pantoate--beta-alanine ligase HAMAP MF_01349 | ||||||
| Region | 254 – 490 | 237 | Cytidylate kinase HAMAP MF_01349 | ||||||
Sites | |||||||||
| Active site | 8 | 1 | Proton donor By similarity | ||||||
| Binding site | 35 | 1 | Beta-alanine By similarity | ||||||
| Binding site | 35 | 1 | Pantoate By similarity | ||||||
| Binding site | 130 | 1 | Pantoate By similarity | ||||||
| Binding site | 153 | 1 | ATP; via amide nitrogen and carbonyl oxygen By similarity | ||||||
Sequences
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References
| [1] | Genoscope Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CT971583 Genomic DNA. Translation: CAK22900.1. | |
| RefSeq | YP_001224197.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A5GIY5. |
Genome annotation databases | |
| GeneID | 5146424. |
| GenomeReviews | Gene locus SynWH7803_0474 in contig CT971583_GR. |
| KEGG | syx:SynWH7803_0474. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| OMA | LGEKDWQ. |
Family and domain databases | |
| HAMAP | MF_01349. [Tree] |
| InterPro | IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kin_d. IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit. |
| PANTHER | PTHR21299:SF1. Pantoate_ligase. 1 hit. |
| Pfam | PF02224. Cytidylate_kin. 1 hit. PF02569. Pantoate_ligase. 1 hit. [Graphical view] |
| ProDom | PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00017. cmk. 1 hit. TIGR00018. panC. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PANCY_SYNPW | ||||||||
| Accession | Primary (citable) accession number: A5GIY5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


