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A5GIY5

- PANCY_SYNPW

UniProt

A5GIY5 - PANCY_SYNPW

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Protein
Bifunctional pantoate ligase/cytidylate kinase
Gene
panC/cmk, SynWH7803_0474
Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation
Displays a CMP kinase activity By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei8 – 81Proton donor By similarity
Binding sitei35 – 351Beta-alanine By similarity
Binding sitei35 – 351Pantoate By similarity
Binding sitei130 – 1301Pantoate By similarity
Binding sitei153 – 1531ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1 – 88ATP By similarity
Nucleotide bindingi124 – 1274ATP By similarity
Nucleotide bindingi161 – 1644ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cytidylate kinase activity Source: UniProtKB-HAMAP
  3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
  2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ligase, Transferase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinase
Including the following 2 domains:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Cytidylate kinase (EC:2.7.4.14)
Short name:
CK
Alternative name(s):
Cytidine monophosphate kinase
Short name:
CMP kinase
Gene namesi
Name:panC/cmk
Ordered Locus Names:SynWH7803_0474
OrganismiSynechococcus sp. (strain WH7803)
Taxonomic identifieri32051 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001566: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
PRO_0000333302Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi32051.SynWH7803_0474.

Structurei

3D structure databases

ProteinModelPortaliA5GIY5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 253253Pantoate--beta-alanine ligaseUniRule annotation
Add
BLAST
Regioni254 – 490237Cytidylate kinaseUniRule annotation
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Phylogenomic databases

eggNOGiCOG0283.
HOGENOMiHOG000233355.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamiPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

A5GIY5-1 [UniParc]FASTAAdd to Basket

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MGGLHQGHAR LIATAVTSCG GKGSVLVSTF VNPLQFGVDE DFDCYPRTFE    50
DDCALAEQAG ASALWCPDER QVYPYGTSEG WRLQAPARLT AHLCGPWRSG 100
HFDGVVTVVM RLLGLVRPHQ LWLGEKDWQQ LTILRHLVND FGLRVRVRGC 150
PTVREGDGLA ASSRNRYLGD AQRTVASAFS SALCATARDV CAGSVDEASA 200
QVALRQQLRE AGLEVEYVET VDPVTLQPAR PGRSIRLLAA AVRCGETRLI 250
DHVFIMTRSP IVAIDGPAGA GKSTVTRAFA ERMGLLYLDT GAMYRAVTWW 300
VQSNGADPSS APAVEALLEG LEVDLSPLKD GVQTVRVNGR DITDAIRDPE 350
VTGSVSLVAA HPCVRALLTK QQQRLGERGG LVAEGRDIGT AVFPDADVKV 400
FLTATPEERA RRRAKDLEAR GHAVPDLAAL EAQIVERDRL DSTREVAPLV 450
QADDATELIT DGMSIEAVID ALEDLFRFRV AKEIWPTPQG 490
Length:490
Mass (Da):53,061
Last modified:June 12, 2007 - v1
Checksum:i93949554E45DAA97
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT971583 Genomic DNA. Translation: CAK22900.1.
RefSeqiWP_011932388.1. NC_009481.1.
YP_001224197.1. NC_009481.1.

Genome annotation databases

EnsemblBacteriaiCAK22900; CAK22900; SynWH7803_0474.
GeneIDi5146424.
KEGGisyx:SynWH7803_0474.
PATRICi23827012. VBISynSp43824_0480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT971583 Genomic DNA. Translation: CAK22900.1 .
RefSeqi WP_011932388.1. NC_009481.1.
YP_001224197.1. NC_009481.1.

3D structure databases

ProteinModelPortali A5GIY5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 32051.SynWH7803_0474.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK22900 ; CAK22900 ; SynWH7803_0474 .
GeneIDi 5146424.
KEGGi syx:SynWH7803_0474.
PATRICi 23827012. VBISynSp43824_0480.

Phylogenomic databases

eggNOGi COG0283.
HOGENOMi HOG000233355.
KOi K13799.
OMAi LGEKDWQ.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProi IPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
Pfami PF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Genoscope
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH7803.

Entry informationi

Entry nameiPANCY_SYNPW
AccessioniPrimary (citable) accession number: A5GIY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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