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A5GIY5

- PANCY_SYNPW

UniProt

A5GIY5 - PANCY_SYNPW

Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation
    Displays a CMP kinase activity.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
    ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei8 – 81Proton donorUniRule annotation
    Binding sitei35 – 351Beta-alanineUniRule annotation
    Binding sitei35 – 351PantoateUniRule annotation
    Binding sitei130 – 1301PantoateUniRule annotation
    Binding sitei153 – 1531ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1 – 88ATPUniRule annotation
    Nucleotide bindingi124 – 1274ATPUniRule annotation
    Nucleotide bindingi161 – 1644ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. cytidylate kinase activity Source: UniProtKB-HAMAP
    3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
    2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Ligase, Transferase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
    Including the following 2 domains:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Cytidylate kinaseUniRule annotation (EC:2.7.4.14UniRule annotation)
    Short name:
    CKUniRule annotation
    Alternative name(s):
    Cytidine monophosphate kinaseUniRule annotation
    Short name:
    CMP kinaseUniRule annotation
    Gene namesi
    Name:panC/cmkUniRule annotation
    Ordered Locus Names:SynWH7803_0474
    OrganismiSynechococcus sp. (strain WH7803)
    Taxonomic identifieri32051 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001566: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Bifunctional pantoate ligase/cytidylate kinasePRO_0000333302Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi32051.SynWH7803_0474.

    Structurei

    3D structure databases

    ProteinModelPortaliA5GIY5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 253253Pantoate--beta-alanine ligaseAdd
    BLAST
    Regioni254 – 490237Cytidylate kinaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the pantothenate synthetase family.UniRule annotation
    In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0283.
    HOGENOMiHOG000233355.
    KOiK13799.
    OMAiLGEKDWQ.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProiIPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
    PfamiPF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00017. cmk. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5GIY5-1 [UniParc]FASTAAdd to Basket

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    MGGLHQGHAR LIATAVTSCG GKGSVLVSTF VNPLQFGVDE DFDCYPRTFE    50
    DDCALAEQAG ASALWCPDER QVYPYGTSEG WRLQAPARLT AHLCGPWRSG 100
    HFDGVVTVVM RLLGLVRPHQ LWLGEKDWQQ LTILRHLVND FGLRVRVRGC 150
    PTVREGDGLA ASSRNRYLGD AQRTVASAFS SALCATARDV CAGSVDEASA 200
    QVALRQQLRE AGLEVEYVET VDPVTLQPAR PGRSIRLLAA AVRCGETRLI 250
    DHVFIMTRSP IVAIDGPAGA GKSTVTRAFA ERMGLLYLDT GAMYRAVTWW 300
    VQSNGADPSS APAVEALLEG LEVDLSPLKD GVQTVRVNGR DITDAIRDPE 350
    VTGSVSLVAA HPCVRALLTK QQQRLGERGG LVAEGRDIGT AVFPDADVKV 400
    FLTATPEERA RRRAKDLEAR GHAVPDLAAL EAQIVERDRL DSTREVAPLV 450
    QADDATELIT DGMSIEAVID ALEDLFRFRV AKEIWPTPQG 490
    Length:490
    Mass (Da):53,061
    Last modified:June 12, 2007 - v1
    Checksum:i93949554E45DAA97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT971583 Genomic DNA. Translation: CAK22900.1.
    RefSeqiWP_011932388.1. NC_009481.1.
    YP_001224197.1. NC_009481.1.

    Genome annotation databases

    EnsemblBacteriaiCAK22900; CAK22900; SynWH7803_0474.
    GeneIDi5146424.
    KEGGisyx:SynWH7803_0474.
    PATRICi23827012. VBISynSp43824_0480.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT971583 Genomic DNA. Translation: CAK22900.1 .
    RefSeqi WP_011932388.1. NC_009481.1.
    YP_001224197.1. NC_009481.1.

    3D structure databases

    ProteinModelPortali A5GIY5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 32051.SynWH7803_0474.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK22900 ; CAK22900 ; SynWH7803_0474 .
    GeneIDi 5146424.
    KEGGi syx:SynWH7803_0474.
    PATRICi 23827012. VBISynSp43824_0480.

    Phylogenomic databases

    eggNOGi COG0283.
    HOGENOMi HOG000233355.
    KOi K13799.
    OMAi LGEKDWQ.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProi IPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
    Pfami PF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00017. cmk. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Genoscope
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH7803.

    Entry informationi

    Entry nameiPANCY_SYNPW
    AccessioniPrimary (citable) accession number: A5GIY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3