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Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation
Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional pantoate ligase/cytidylate kinase (panC/cmk)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei8Proton donorUniRule annotation1
Binding sitei35Beta-alanineUniRule annotation1
Binding sitei35PantoateUniRule annotation1
Binding sitei130PantoateUniRule annotation1
Binding sitei153ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1 – 8ATPUniRule annotation8
Nucleotide bindingi124 – 127ATPUniRule annotation4
Nucleotide bindingi161 – 164ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Ligase, Multifunctional enzyme, Transferase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
Including the following 2 domains:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Cytidylate kinaseUniRule annotation (EC:2.7.4.25UniRule annotation)
Short name:
CKUniRule annotation
Alternative name(s):
Cytidine monophosphate kinaseUniRule annotation
Short name:
CMP kinaseUniRule annotation
Gene namesi
Name:panC/cmkUniRule annotation
Ordered Locus Names:SynWH7803_0474
OrganismiSynechococcus sp. (strain WH7803)
Taxonomic identifieri32051 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001566 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003333021 – 490Bifunctional pantoate ligase/cytidylate kinaseAdd BLAST490

Proteomic databases

PRIDEiA5GIY5

Interactioni

Protein-protein interaction databases

STRINGi32051.SynWH7803_0474

Structurei

3D structure databases

ProteinModelPortaliA5GIY5
SMRiA5GIY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 253Pantoate--beta-alanine ligaseAdd BLAST253
Regioni254 – 490Cytidylate kinaseUniRule annotationAdd BLAST237

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.UniRule annotation
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAT Bacteria
COG0283 LUCA
COG0414 LUCA
HOGENOMiHOG000233355
KOiK13799
OMAiLGEKDWQ
OrthoDBiPOG091H00FM

Family and domain databases

Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00238 Cytidyl_kinase_type1, 1 hit
MF_00158 PanC, 1 hit
MF_01349 PanCY, 1 hit
InterProiView protein in InterPro
IPR003136 Cytidylate_kin
IPR011994 Cytidylate_kinase_dom
IPR027417 P-loop_NTPase
IPR003721 Pantoate_ligase
IPR024894 Pantoate_ligase/cytidylate_kin
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF02224 Cytidylate_kin, 1 hit
PF02569 Pantoate_ligase, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00017 cmk, 1 hit
TIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

A5GIY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGLHQGHAR LIATAVTSCG GKGSVLVSTF VNPLQFGVDE DFDCYPRTFE
60 70 80 90 100
DDCALAEQAG ASALWCPDER QVYPYGTSEG WRLQAPARLT AHLCGPWRSG
110 120 130 140 150
HFDGVVTVVM RLLGLVRPHQ LWLGEKDWQQ LTILRHLVND FGLRVRVRGC
160 170 180 190 200
PTVREGDGLA ASSRNRYLGD AQRTVASAFS SALCATARDV CAGSVDEASA
210 220 230 240 250
QVALRQQLRE AGLEVEYVET VDPVTLQPAR PGRSIRLLAA AVRCGETRLI
260 270 280 290 300
DHVFIMTRSP IVAIDGPAGA GKSTVTRAFA ERMGLLYLDT GAMYRAVTWW
310 320 330 340 350
VQSNGADPSS APAVEALLEG LEVDLSPLKD GVQTVRVNGR DITDAIRDPE
360 370 380 390 400
VTGSVSLVAA HPCVRALLTK QQQRLGERGG LVAEGRDIGT AVFPDADVKV
410 420 430 440 450
FLTATPEERA RRRAKDLEAR GHAVPDLAAL EAQIVERDRL DSTREVAPLV
460 470 480 490
QADDATELIT DGMSIEAVID ALEDLFRFRV AKEIWPTPQG
Length:490
Mass (Da):53,061
Last modified:June 12, 2007 - v1
Checksum:i93949554E45DAA97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT971583 Genomic DNA Translation: CAK22900.1

Genome annotation databases

EnsemblBacteriaiCAK22900; CAK22900; SynWH7803_0474
KEGGisyx:SynWH7803_0474

Similar proteinsi

Entry informationi

Entry nameiPANCY_SYNPW
AccessioniPrimary (citable) accession number: A5GIY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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