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A5GIY3

- PUR5_SYNPW

UniProt

A5GIY3 - PUR5_SYNPW

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, SynWH7803_0472
Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:SynWH7803_0472
OrganismiSynechococcus sp. (strain WH7803)
Taxonomic identifieri32051 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001566: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_1000046479Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi32051.SynWH7803_0472.

Structurei

3D structure databases

ProteinModelPortaliA5GIY3.
SMRiA5GIY3. Positions 1-333.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiCFEIPAG.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A5GIY3-1 [UniParc]FASTAAdd to Basket

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MDYRSAGVDV EAGRAFVDRI RTSVEATHRP EVVGGLGGFG GLMRLPEGLR    50
KPLLVSGTDG VGTKLELAQD HKSHHNVGID LVAMCVNDVI TSGAEPLFFL 100
DYMATGALSP DAMAEVVEGI ADGCRQSGCA LLGGETAEMP GFYPPGRYDL 150
AGFCVAVVEE DNLIDGRRVQ AGDSILGIAS SGVHSNGFSL VRKILECCAA 200
GADTRVGPEQ TPVIEALLKP THLYGALVRT LLGANTRIHA MAHITGGGIP 250
ENLPRCLPKG LMASVDPHSW PRPELFSWLQ TQGELQERDL WHTFNLGIGY 300
CLILPEADVE GARTLCSNSG FESWVIGEVI PASEPQDGPV AGLPA 345
Length:345
Mass (Da):36,490
Last modified:June 12, 2007 - v1
Checksum:i967C680EDF76C68F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT971583 Genomic DNA. Translation: CAK22898.1.
RefSeqiWP_011932386.1. NC_009481.1.
YP_001224195.1. NC_009481.1.

Genome annotation databases

EnsemblBacteriaiCAK22898; CAK22898; SynWH7803_0472.
GeneIDi5146847.
KEGGisyx:SynWH7803_0472.
PATRICi23827004. VBISynSp43824_0476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT971583 Genomic DNA. Translation: CAK22898.1 .
RefSeqi WP_011932386.1. NC_009481.1.
YP_001224195.1. NC_009481.1.

3D structure databases

ProteinModelPortali A5GIY3.
SMRi A5GIY3. Positions 1-333.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 32051.SynWH7803_0472.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK22898 ; CAK22898 ; SynWH7803_0472 .
GeneIDi 5146847.
KEGGi syx:SynWH7803_0472.
PATRICi 23827004. VBISynSp43824_0476.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi CFEIPAG.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Genoscope
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH7803.

Entry informationi

Entry nameiPUR5_SYNPW
AccessioniPrimary (citable) accession number: A5GIY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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