ID   A5GIP6_SYNPW            Unreviewed;      1532 AA.
AC   A5GIP6;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   RecName: Full=glutamate synthase (ferredoxin) {ECO:0000256|ARBA:ARBA00039085};
DE            EC=1.4.7.1 {ECO:0000256|ARBA:ARBA00039085};
GN   Name=gltS {ECO:0000313|EMBL:CAK22811.1};
GN   OrderedLocusNames=SynWH7803_0385 {ECO:0000313|EMBL:CAK22811.1};
OS   Synechococcus sp. (strain WH7803).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Synechococcaceae;
OC   Synechococcus.
OX   NCBI_TaxID=32051 {ECO:0000313|EMBL:CAK22811.1, ECO:0000313|Proteomes:UP000001566};
RN   [1] {ECO:0000313|Proteomes:UP000001566}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WH7803 {ECO:0000313|Proteomes:UP000001566};
RG   Genoscope;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|ARBA:ARBA00001917};
CC   -!- COFACTOR:
CC       Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137;
CC         Evidence={ECO:0000256|ARBA:ARBA00001927};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-glutamate biosynthesis via GLT
CC       pathway; L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin
CC       route): step 1/1. {ECO:0000256|ARBA:ARBA00037928}.
CC   -!- PATHWAY: Energy metabolism; nitrogen metabolism.
CC       {ECO:0000256|ARBA:ARBA00004802}.
CC   -!- PATHWAY: Nitrogen metabolism. {ECO:0000256|ARBA:ARBA00004909}.
CC   -!- SIMILARITY: Belongs to the glutamate synthase family.
CC       {ECO:0000256|ARBA:ARBA00009716}.
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DR   EMBL; CT971583; CAK22811.1; -; Genomic_DNA.
DR   STRING; 32051.SynWH7803_0385; -.
DR   MEROPS; C44.003; -.
DR   KEGG; syx:SynWH7803_0385; -.
DR   eggNOG; COG0067; Bacteria.
DR   eggNOG; COG0069; Bacteria.
DR   eggNOG; COG0070; Bacteria.
DR   HOGENOM; CLU_000422_8_2_3; -.
DR   OrthoDB; 9758182at2; -.
DR   Proteomes; UP000001566; Chromosome.
DR   GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0016041; F:glutamate synthase (ferredoxin) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006537; P:glutamate biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00982; gltB_C; 1.
DR   CDD; cd00713; GltS; 1.
DR   CDD; cd02808; GltS_FMN; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 2.
DR   Gene3D; 2.160.20.60; Glutamate synthase, alpha subunit, C-terminal domain; 1.
DR   Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017932; GATase_2_dom.
DR   InterPro; IPR002489; Glu_synth_asu_C.
DR   InterPro; IPR036485; Glu_synth_asu_C_sf.
DR   InterPro; IPR006982; Glu_synth_centr_N.
DR   InterPro; IPR002932; Glu_synthdom.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   PANTHER; PTHR11938; FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR11938:SF1; FERREDOXIN-DEPENDENT GLUTAMATE SYNTHASE 1, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   Pfam; PF00310; GATase_2; 1.
DR   Pfam; PF04898; Glu_syn_central; 1.
DR   Pfam; PF01645; Glu_synthase; 1.
DR   Pfam; PF01493; GXGXG; 1.
DR   SUPFAM; SSF69336; Alpha subunit of glutamate synthase, C-terminal domain; 1.
DR   SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR   SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR   PROSITE; PS51278; GATASE_TYPE_2; 1.
PE   3: Inferred from homology;
KW   3Fe-4S {ECO:0000256|ARBA:ARBA00023291};
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   FMN {ECO:0000256|ARBA:ARBA00022643};
KW   Glutamate biosynthesis {ECO:0000256|ARBA:ARBA00023164};
KW   Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:CAK22811.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001566}.
FT   DOMAIN          27..419
FT                   /note="Glutamine amidotransferase type-2"
FT                   /evidence="ECO:0000259|PROSITE:PS51278"
SQ   SEQUENCE   1532 AA;  163934 MW;  2CB9FA7B096D6BC5 CRC64;
     MSHPTGSLWP YSDSAAPEAV AGEKDACGVG FLAQLSGETS HWVLQQALRG LGCMEHRGGC
     GGDGDSGDGA GVLCQIPWTY LKAVWPEAAS ARGLGMMFMP QDPERRELAR RFCKEEAEAL
     GLTSAGWRVV PVDSSVLGPM ARDTAPVIEQ WSLAGGPDGD AFEALLLRLR RRIGARARQA
     WGFEGSRDLY VASLSSRTVV YKGMVRSEVL AQYYADLRDP RFEVSFAVYH RRFSTNTLPR
     WPLAQPMRLL GHNGEINTLL GNLNWAKASE ASLADVWGEA ANDLNPVVNP AFSDSANLDA
     TLELMVRSGR SITDSLITLV PEAFRNQPDL EDRPAVTAMY EFNAGIQEPW DGPALLVFAD
     GKRVGATLDR NGLRPARWCT TADGFVIMGS ETGVVDLSGK TVVQKGRLGP GQMVAVDLEN
     GQLLDNWTVK EDAAGRFPYG DWLQHHRRSV EAQPWTQDRQ IGELDLLRLQ TAMGFTAEDF
     DLVIEDMAGL GKEPTYCMGD DIPLAVLSDK PHLLYDYFKQ RFAQVTNPPI DPLREKLVMS
     LEMHLGERRP ALKPQAEAAA VIHLDTPVLN EAELAAISEQ GLPVATLSTH VAVEACAGGL
     SSALQRLCES AEEAVRGGAQ VLVLSDRVDG SGAAAQLTAT SVAMPALLAV GAVHHHLLRQ
     KLRLRCSLVI DTAQCWSTHH MACLIGYGAS AVCPWLTWET TRHWLAHPKT QKRIEQGKLP
     ALDADKVQAN VRVSLENGLR KILSKIGISL LASYHGAQIF EAIGLGADVI DTAFSGTTSR
     VAGMTLAELA NETLSLHAKA FPELNRSKLE FMGFVQYRTG GEYHLNSPDM AKALHAAVKT
     GPGYDHFSTY KTLLENRPVT ALRDLLEFKL APTPLPLDQV ESAESLCKRF CTGGMSLGAL
     SREAHEVLAV AMNRIGGKSN SGEGGEDPAR FQVLHDVDAE GRSQAFPSIG GLRNGDTACS
     AIKQIASGRF GVTAEYLRSG KQLEIKVAQG AKPGEGGQLP GPKVDDYIAW LRNSKPGVAL
     ISPPPHHDIY SIEDLAQLIH DLHQVHPKAP VSVKLVAEIG IGTIAAGVAK ANADVIQISG
     HDGGTGASPL SSIKHAGSPW ELGLTEVHRS LLENGLRDRV LLRADGGLKT GWDVVIAALL
     GAEEYGFGSV AMIAEGCIMA RVCHTNNCPV GVATQKEALR KRFTGVPEHV VNFFWYVAEE
     VRQLLSLLGV AKLEDLIGRS DLLQPRAVQL AKTQGVDLSS LLAPIQGSEE RSWLRHSAEA
     HGNGPILEDQ LLADAELMAA VESHGSLSRT IAIINTDRSV GARLAGEIAQ RHGNRGFKGQ
     LNLTFQGAAG QSFGAFLVQG MNVRLEGEAN DYVGKGMNSG RISLVPSDGC ANPGDQVILG
     NTCLYGATGG ELFAHGRAGE RFGVRNSGAR TVVEGAGDHC CEYMTGGVVV VLGSTGRNVG
     AGMTGGVTFL LDEGDRVTAR VNPEIVAVCS LTTSQQEETL KELLEAHVAA TGSSKASALL
     ADWAAAKGRF KVLIPPSERA AMGLVDQQAV AA
//