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A5GIF4

- PUR9_SYNPW

UniProt

A5GIF4 - PUR9_SYNPW

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, SynWH7803_0293
Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:SynWH7803_0293
OrganismiSynechococcus sp. (strain WH7803)
Taxonomic identifieri32051 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001566: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_1000018978Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi32051.SynWH7803_0293.

Structurei

3D structure databases

ProteinModelPortaliA5GIF4.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiVMSERIP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A5GIF4-1 [UniParc]FASTAAdd to Basket

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MAPTALLSVS DKSGLLPLAK TLHERYGYQL LSSGGTAKVL QEAGLPVTPV    50
ADHTGAPEIL GGRVKTLHPR IHGGILARRG DPAHEADLQA QQITPIDVVV 100
VNLYPFRETV SDPAVSWERA IENIDIGGPT MVRSAAKNHD HVAVLTDPDQ 150
YDRFLQDLAA SGGAVSAAVR RRLALDAFAH TAAYDAAITR WMQNRPELQP 200
ADDGSASSLP WLEALPLRQR LRYGENPHQG AAWYSAPKAG WGGAIQLQGK 250
ELSTNNLLDL EAALATVREF GYGEGGSHPA QRPAAVVVKH TNPCGVAVAD 300
GHAAALTRAL DGDRVSAFGG IVAVNGRVDA PAARELTSLF LECVVAPEYA 350
PEAREILASK GNLRLLELPP TAIDAAGHDH VRSILGGLLV QDLDDQPVAA 400
DGWTVASERA PSQAERDDLC FAWQLVRHVR SNAIVVARNG QSLGIGAGQM 450
NRVGSARIAL EASGDGARGA VLASDGFFPF DDTVRLAAQH GITAVIHPGG 500
SKRDQDSIKA CNELGLAMLL TGQRHFLH 528
Length:528
Mass (Da):55,881
Last modified:June 12, 2007 - v1
Checksum:i730623139D12BFCC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT971583 Genomic DNA. Translation: CAK22719.1.
RefSeqiWP_011932221.1. NC_009481.1.
YP_001224016.1. NC_009481.1.

Genome annotation databases

EnsemblBacteriaiCAK22719; CAK22719; SynWH7803_0293.
GeneIDi5146762.
KEGGisyx:SynWH7803_0293.
PATRICi23826628. VBISynSp43824_0296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT971583 Genomic DNA. Translation: CAK22719.1 .
RefSeqi WP_011932221.1. NC_009481.1.
YP_001224016.1. NC_009481.1.

3D structure databases

ProteinModelPortali A5GIF4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 32051.SynWH7803_0293.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK22719 ; CAK22719 ; SynWH7803_0293 .
GeneIDi 5146762.
KEGGi syx:SynWH7803_0293.
PATRICi 23826628. VBISynSp43824_0296.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi VMSERIP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Genoscope
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH7803.

Entry informationi

Entry nameiPUR9_SYNPW
AccessioniPrimary (citable) accession number: A5GIF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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