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A5GIF4 (PUR9_SYNPW) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:SynWH7803_0293
OrganismSynechococcus sp. (strain WH7803) [Complete proteome] [HAMAP]
Taxonomic identifier32051 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 528528Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000018978

Sequences

Sequence LengthMass (Da)Tools
A5GIF4 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 730623139D12BFCC

FASTA52855,881
        10         20         30         40         50         60 
MAPTALLSVS DKSGLLPLAK TLHERYGYQL LSSGGTAKVL QEAGLPVTPV ADHTGAPEIL 

        70         80         90        100        110        120 
GGRVKTLHPR IHGGILARRG DPAHEADLQA QQITPIDVVV VNLYPFRETV SDPAVSWERA 

       130        140        150        160        170        180 
IENIDIGGPT MVRSAAKNHD HVAVLTDPDQ YDRFLQDLAA SGGAVSAAVR RRLALDAFAH 

       190        200        210        220        230        240 
TAAYDAAITR WMQNRPELQP ADDGSASSLP WLEALPLRQR LRYGENPHQG AAWYSAPKAG 

       250        260        270        280        290        300 
WGGAIQLQGK ELSTNNLLDL EAALATVREF GYGEGGSHPA QRPAAVVVKH TNPCGVAVAD 

       310        320        330        340        350        360 
GHAAALTRAL DGDRVSAFGG IVAVNGRVDA PAARELTSLF LECVVAPEYA PEAREILASK 

       370        380        390        400        410        420 
GNLRLLELPP TAIDAAGHDH VRSILGGLLV QDLDDQPVAA DGWTVASERA PSQAERDDLC 

       430        440        450        460        470        480 
FAWQLVRHVR SNAIVVARNG QSLGIGAGQM NRVGSARIAL EASGDGARGA VLASDGFFPF 

       490        500        510        520 
DDTVRLAAQH GITAVIHPGG SKRDQDSIKA CNELGLAMLL TGQRHFLH 

« Hide

References

[1]Genoscope
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WH7803.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CT971583 Genomic DNA. Translation: CAK22719.1.
RefSeqYP_001224016.1. NC_009481.1.

3D structure databases

ProteinModelPortalA5GIF4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING32051.SynWH7803_0293.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAK22719; CAK22719; SynWH7803_0293.
GeneID5146762.
KEGGsyx:SynWH7803_0293.
PATRIC23826628. VBISynSp43824_0296.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMADLLFAWK.
OrthoDBEOG6QCDFF.
ProtClustDBPRK00881.

Enzyme and pathway databases

UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_SYNPW
AccessionPrimary (citable) accession number: A5GIF4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways