A5GI92 (KDSA_SYNPW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-dehydro-3-deoxyphosphooctonate aldolase
EC=2.5.1.55

Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name=KDO 8-P synthase
Short name=KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase

Gene names

Name:	kdsA
Ordered Locus Names:	SynWH7803_0231

Organism

Synechococcus sp. (strain WH7803) [Complete proteome] [HAMAP]

Taxonomic identifier

32051 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056
Pathway	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056
Subcellular location	Cytoplasm By similarity HAMAP MF_00056.
Sequence similarities	Belongs to the KdsA family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-8-phosphooctulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	2-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056		PRO_0000304498

Sequences

	Sequence		Length	Mass (Da)
	A5GI92 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: C8AEEFF3EEAADFB1	FASTA	283	30,122
	10 20 30 40 50 60 MAARQVSLGS ITFANDAPFV LIGGVNVLES QQFALDAAAV YADVCRRLSI PLVFKASFDK 70 80 90 100 110 120 ANRSSIHSFR GPGLSDGLAM LQAVKDTHGI PVITDVHTPE QAAPAAEVCD IIQLPAFLAR 130 140 150 160 170 180 QTDLVQAMAG TGAVINIKKP QFLSPSQMAN VVEKFRECGN EQLLICERGS NFGYDNLVVD 190 200 210 220 230 240 MLGFGVMKRC CDDLPLIFDV THALQCRDPG GAASGGRRSQ VLDLARAGMA VGLAGLFLEA 250 260 270 280 HPDPSQARCD GPSALPLHQL EPFLSQLKAV DDLVKSLPAL TIQ

References

[1]	Genoscope Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WH7803.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT971583 Genomic DNA. Translation: CAK22657.1.
RefSeq	YP_001223954.1. NC_009481.1.
3D structure databases
ProteinModelPortal	A5GI92.
SMR	A5GI92. Positions 1-280.
ModBase	Search...
Protein-protein interaction databases
STRING	A5GI92.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5146727.
GenomeReviews	Gene locus SynWH7803_0231 in contig CT971583_GR.
KEGG	syx:SynWH7803_0231.
PATRIC	23826504. VBISynSp43824_0235.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2877.
HOGENOM	HBG575990.
OMA	QLILCDR.
PhylomeDB	A5GI92.
ProtClustDB	PRK05198.
Enzyme and pathway databases
BioCyc	SSP32051:SYNWH7803_0231-MONOMER.
Family and domain databases
HAMAP	MF_00056. KDO8P_synth. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006269. KDO8P_synthase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01627.
PANTHER	PTHR21057:SF2. KDO8P_synthase. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01362. KDO8P_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSA_SYNPW

Accession

Primary (citable) accession number: A5GI92

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	June 12, 2007
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program