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A5GHN9

- MURC_SYNPW

UniProt

A5GHN9 - MURC_SYNPW

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Protein

UDP-N-acetylmuramate--L-alanine ligase

Gene
murC, SynWH7803_0028
Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotation

Catalytic activityi

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi125 – 1317ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. UDP-N-acetylmuramate-L-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramate--L-alanine ligase (EC:6.3.2.8)
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene namesi
Name:murC
Ordered Locus Names:SynWH7803_0028
OrganismiSynechococcus sp. (strain WH7803)
Taxonomic identifieri32051 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001566: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486UDP-N-acetylmuramate--L-alanine ligaseUniRule annotationPRO_0000336872Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi32051.SynWH7803_0028.

Structurei

3D structure databases

ProteinModelPortaliA5GHN9.

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.

Phylogenomic databases

eggNOGiCOG0773.
HOGENOMiHOG000256031.
KOiK01924.
OMAiPSEIRCT.
OrthoDBiEOG64BQ73.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00046. MurC.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01082. murC. 1 hit.

Sequencei

Sequence statusi: Complete.

A5GHN9-1 [UniParc]FASTAAdd to Basket

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MRSLVCTLDI QSPVHFIGAG GIGMSALARI LLSRGHRVSG SDRRLSPAME    50
SLKTAGMVAF ESQAAANFQA LDRLDRSSPI VVISSAIPDH NPELVAARER 100
QLEVWHRSDL LAALIDQQPS IAIAGSHGKT TTSTVVTTLL HGAGEDPTAV 150
IGGIVPCYDS NGHAGQGRLL VAEADESDGS LVKFRASLGV ITNLELDHTD 200
HYRDLDDLIA TLQRFGDGCK RLLANQDDPI LSEHFQADAW WSVQRSDNVD 250
FAGLPVALEG DRTIADLYEQ GTFVGQITLP MPGLHNLSNT IGALAACRME 300
GVPLEHLISH LSELKTPGRR FDYRGDWQGR QIVDDYAHHP SEVAATLNMA 350
NLMVSSGRSP LPRSPQRLVA VFQPHRYSRT QEFQTEFARA LLSAELVLLA 400
PIFAAGEAEM PGVNSEALAS VMQELSTQQS VLVASTMDEL VSLVKEHSLP 450
DDLVLAMGAG DVNSLWSRLS QSSSEGQASC PPALAA 486
Length:486
Mass (Da):52,252
Last modified:June 12, 2007 - v1
Checksum:iB930A27B3E0D0525
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT971583 Genomic DNA. Translation: CAK22454.1.
RefSeqiWP_011931963.1. NC_009481.1.
YP_001223751.1. NC_009481.1.

Genome annotation databases

EnsemblBacteriaiCAK22454; CAK22454; SynWH7803_0028.
GeneIDi5146173.
KEGGisyx:SynWH7803_0028.
PATRICi23826088. VBISynSp43824_0030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT971583 Genomic DNA. Translation: CAK22454.1 .
RefSeqi WP_011931963.1. NC_009481.1.
YP_001223751.1. NC_009481.1.

3D structure databases

ProteinModelPortali A5GHN9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 32051.SynWH7803_0028.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK22454 ; CAK22454 ; SynWH7803_0028 .
GeneIDi 5146173.
KEGGi syx:SynWH7803_0028.
PATRICi 23826088. VBISynSp43824_0030.

Phylogenomic databases

eggNOGi COG0773.
HOGENOMi HOG000256031.
KOi K01924.
OMAi PSEIRCT.
OrthoDBi EOG64BQ73.

Enzyme and pathway databases

UniPathwayi UPA00219 .

Family and domain databases

Gene3Di 3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPi MF_00046. MurC.
InterProi IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view ]
Pfami PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsi TIGR01082. murC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Genoscope
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH7803.

Entry informationi

Entry nameiMURC_SYNPW
AccessioniPrimary (citable) accession number: A5GHN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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