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A5GHN9 (MURC_SYNPW) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramate--L-alanine ligase

EC=6.3.2.8
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene names
Name:murC
Ordered Locus Names:SynWH7803_0028
OrganismSynechococcus sp. (strain WH7803) [Complete proteome] [HAMAP]
Taxonomic identifier32051 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00046

Catalytic activity

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP-Rule MF_00046

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00046

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00046.

Sequence similarities

Belongs to the MurCDEF family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486UDP-N-acetylmuramate--L-alanine ligase HAMAP-Rule MF_00046
PRO_0000336872

Regions

Nucleotide binding125 – 1317ATP Potential

Sequences

Sequence LengthMass (Da)Tools
A5GHN9 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: B930A27B3E0D0525

FASTA48652,252
        10         20         30         40         50         60 
MRSLVCTLDI QSPVHFIGAG GIGMSALARI LLSRGHRVSG SDRRLSPAME SLKTAGMVAF 

        70         80         90        100        110        120 
ESQAAANFQA LDRLDRSSPI VVISSAIPDH NPELVAARER QLEVWHRSDL LAALIDQQPS 

       130        140        150        160        170        180 
IAIAGSHGKT TTSTVVTTLL HGAGEDPTAV IGGIVPCYDS NGHAGQGRLL VAEADESDGS 

       190        200        210        220        230        240 
LVKFRASLGV ITNLELDHTD HYRDLDDLIA TLQRFGDGCK RLLANQDDPI LSEHFQADAW 

       250        260        270        280        290        300 
WSVQRSDNVD FAGLPVALEG DRTIADLYEQ GTFVGQITLP MPGLHNLSNT IGALAACRME 

       310        320        330        340        350        360 
GVPLEHLISH LSELKTPGRR FDYRGDWQGR QIVDDYAHHP SEVAATLNMA NLMVSSGRSP 

       370        380        390        400        410        420 
LPRSPQRLVA VFQPHRYSRT QEFQTEFARA LLSAELVLLA PIFAAGEAEM PGVNSEALAS 

       430        440        450        460        470        480 
VMQELSTQQS VLVASTMDEL VSLVKEHSLP DDLVLAMGAG DVNSLWSRLS QSSSEGQASC 


PPALAA 

« Hide

References

[1]Genoscope
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WH7803.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CT971583 Genomic DNA. Translation: CAK22454.1.
RefSeqYP_001223751.1. NC_009481.1.

3D structure databases

ProteinModelPortalA5GHN9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING32051.SynWH7803_0028.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAK22454; CAK22454; SynWH7803_0028.
GeneID5146173.
KEGGsyx:SynWH7803_0028.
PATRIC23826088. VBISynSp43824_0030.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0773.
HOGENOMHOG000256031.
KOK01924.
OMAPSEIRCT.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPMF_00046. MurC.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsTIGR01082. murC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURC_SYNPW
AccessionPrimary (citable) accession number: A5GHN9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: June 11, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways