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A5GHN9

- MURC_SYNPW

UniProt

A5GHN9 - MURC_SYNPW

Protein

UDP-N-acetylmuramate--L-alanine ligase

Gene

murC

Organism
Synechococcus sp. (strain WH7803)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Cell wall formation.UniRule annotation

    Catalytic activityi

    ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi125 – 1317ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. UDP-N-acetylmuramate-L-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylmuramate--L-alanine ligaseUniRule annotation (EC:6.3.2.8UniRule annotation)
    Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetaseUniRule annotation
    Gene namesi
    Name:murCUniRule annotation
    Ordered Locus Names:SynWH7803_0028
    OrganismiSynechococcus sp. (strain WH7803)
    Taxonomic identifieri32051 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001566: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486UDP-N-acetylmuramate--L-alanine ligasePRO_0000336872Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi32051.SynWH7803_0028.

    Structurei

    3D structure databases

    ProteinModelPortaliA5GHN9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MurCDEF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0773.
    HOGENOMiHOG000256031.
    KOiK01924.
    OMAiPSEIRCT.
    OrthoDBiEOG64BQ73.

    Family and domain databases

    Gene3Di3.40.1190.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPiMF_00046. MurC.
    InterProiIPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR016040. NAD(P)-bd_dom.
    IPR005758. UDP-N-AcMur_Ala_ligase.
    [Graphical view]
    PfamiPF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsiTIGR01082. murC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5GHN9-1 [UniParc]FASTAAdd to Basket

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    MRSLVCTLDI QSPVHFIGAG GIGMSALARI LLSRGHRVSG SDRRLSPAME    50
    SLKTAGMVAF ESQAAANFQA LDRLDRSSPI VVISSAIPDH NPELVAARER 100
    QLEVWHRSDL LAALIDQQPS IAIAGSHGKT TTSTVVTTLL HGAGEDPTAV 150
    IGGIVPCYDS NGHAGQGRLL VAEADESDGS LVKFRASLGV ITNLELDHTD 200
    HYRDLDDLIA TLQRFGDGCK RLLANQDDPI LSEHFQADAW WSVQRSDNVD 250
    FAGLPVALEG DRTIADLYEQ GTFVGQITLP MPGLHNLSNT IGALAACRME 300
    GVPLEHLISH LSELKTPGRR FDYRGDWQGR QIVDDYAHHP SEVAATLNMA 350
    NLMVSSGRSP LPRSPQRLVA VFQPHRYSRT QEFQTEFARA LLSAELVLLA 400
    PIFAAGEAEM PGVNSEALAS VMQELSTQQS VLVASTMDEL VSLVKEHSLP 450
    DDLVLAMGAG DVNSLWSRLS QSSSEGQASC PPALAA 486
    Length:486
    Mass (Da):52,252
    Last modified:June 12, 2007 - v1
    Checksum:iB930A27B3E0D0525
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT971583 Genomic DNA. Translation: CAK22454.1.
    RefSeqiWP_011931963.1. NC_009481.1.
    YP_001223751.1. NC_009481.1.

    Genome annotation databases

    EnsemblBacteriaiCAK22454; CAK22454; SynWH7803_0028.
    GeneIDi5146173.
    KEGGisyx:SynWH7803_0028.
    PATRICi23826088. VBISynSp43824_0030.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT971583 Genomic DNA. Translation: CAK22454.1 .
    RefSeqi WP_011931963.1. NC_009481.1.
    YP_001223751.1. NC_009481.1.

    3D structure databases

    ProteinModelPortali A5GHN9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 32051.SynWH7803_0028.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK22454 ; CAK22454 ; SynWH7803_0028 .
    GeneIDi 5146173.
    KEGGi syx:SynWH7803_0028.
    PATRICi 23826088. VBISynSp43824_0030.

    Phylogenomic databases

    eggNOGi COG0773.
    HOGENOMi HOG000256031.
    KOi K01924.
    OMAi PSEIRCT.
    OrthoDBi EOG64BQ73.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .

    Family and domain databases

    Gene3Di 3.40.1190.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPi MF_00046. MurC.
    InterProi IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR016040. NAD(P)-bd_dom.
    IPR005758. UDP-N-AcMur_Ala_ligase.
    [Graphical view ]
    Pfami PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsi TIGR01082. murC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Genoscope
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH7803.

    Entry informationi

    Entry nameiMURC_SYNPW
    AccessioniPrimary (citable) accession number: A5GHN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3