A5GHN9 (MURC_SYNPW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-N-acetylmuramate--L-alanine ligase
EC=6.3.2.8

Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase

Gene names

Name:	murC
Ordered Locus Names:	SynWH7803_0028

Organism

Synechococcus sp. (strain WH7803) [Complete proteome] [HAMAP]

Taxonomic identifier

32051 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus

Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation By similarity.
Catalytic activity	ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP-Rule MF_00046
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00046
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the MurCDEF family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP UDP-N-acetylmuramate-L-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 486	486	UDP-N-acetylmuramate--L-alanine ligase HAMAP-Rule MF_00046		PRO_0000336872
Regions
	Nucleotide binding	125 – 131	7	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A5GHN9 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: B930A27B3E0D0525	FASTA	486	52,252
	10 20 30 40 50 60 MRSLVCTLDI QSPVHFIGAG GIGMSALARI LLSRGHRVSG SDRRLSPAME SLKTAGMVAF 70 80 90 100 110 120 ESQAAANFQA LDRLDRSSPI VVISSAIPDH NPELVAARER QLEVWHRSDL LAALIDQQPS 130 140 150 160 170 180 IAIAGSHGKT TTSTVVTTLL HGAGEDPTAV IGGIVPCYDS NGHAGQGRLL VAEADESDGS 190 200 210 220 230 240 LVKFRASLGV ITNLELDHTD HYRDLDDLIA TLQRFGDGCK RLLANQDDPI LSEHFQADAW 250 260 270 280 290 300 WSVQRSDNVD FAGLPVALEG DRTIADLYEQ GTFVGQITLP MPGLHNLSNT IGALAACRME 310 320 330 340 350 360 GVPLEHLISH LSELKTPGRR FDYRGDWQGR QIVDDYAHHP SEVAATLNMA NLMVSSGRSP 370 380 390 400 410 420 LPRSPQRLVA VFQPHRYSRT QEFQTEFARA LLSAELVLLA PIFAAGEAEM PGVNSEALAS 430 440 450 460 470 480 VMQELSTQQS VLVASTMDEL VSLVKEHSLP DDLVLAMGAG DVNSLWSRLS QSSSEGQASC PPALAA

References

[1]	Genoscope Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WH7803.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT971583 Genomic DNA. Translation: CAK22454.1.
RefSeq	YP_001223751.1. NC_009481.1.
3D structure databases
ProteinModelPortal	A5GHN9.
ModBase	Search...
Protein-protein interaction databases
STRING	32051.SynWH7803_0028.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAK22454; CAK22454; SynWH7803_0028.
GeneID	5146173.
KEGG	syx:SynWH7803_0028.
PATRIC	23826088. VBISynSp43824_0030.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0773.
HOGENOM	HOG000256031.
KO	K01924.
OMA	YQPHRYS.
ProtClustDB	PRK00421.
Enzyme and pathway databases
UniPathway	UPA00219.
Family and domain databases
Gene3D	3.40.1190.10. 1 hit. 3.40.50.720. 1 hit. 3.90.190.20. 1 hit.
HAMAP	MF_00046. MurC.
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view]
PANTHER	PTHR23135:SF5. PTHR23135:SF5. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
SUPFAM	SSF53244. Mur_ligase_C. 1 hit. SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMs	TIGR01082. murC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURC_SYNPW

Accession

Primary (citable) accession number: A5GHN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	June 12, 2007
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program