Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dolichol-phosphate mannosyltransferase subunit 1

Gene

DPM1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.By similarity

Catalytic activityi

GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-SSC-162699 Synthesis of dolichyl-phosphate mannose
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT2 Glycosyltransferase Family 2

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichol-phosphate mannosyltransferase subunit 1 (EC:2.4.1.83)
Alternative name(s):
Dolichol-phosphate mannose synthase subunit 1
Short name:
DPM synthase subunit 1
Dolichyl-phosphate beta-D-mannosyltransferase subunit 1
Mannose-P-dolichol synthase subunit 1
Short name:
MPD synthase subunit 1
Gene namesi
Name:DPM1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002963962 – 259Dolichol-phosphate mannosyltransferase subunit 1Add BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiA5GFZ5
PeptideAtlasiA5GFZ5
PRIDEiA5GFZ5

Expressioni

Gene expression databases

BgeeiENSSSCG00000007474
GenevisibleiA5GFZ5 SS

Interactioni

Subunit structurei

Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007962

Structurei

3D structure databases

ProteinModelPortaliA5GFZ5
SMRiA5GFZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.Curated

Phylogenomic databases

eggNOGiKOG2978 Eukaryota
COG0463 LUCA
GeneTreeiENSGT00550000075000
HOGENOMiHOG000283250
HOVERGENiHBG018967
InParanoidiA5GFZ5
KOiK00721
OMAiTAGFVCY
OrthoDBiEOG091G0IGG
TreeFamiTF105617

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR001173 Glyco_trans_2-like
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF00535 Glycos_transf_2, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5GFZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEEASRNS RSRWEPEGRF PRQDKYSVLL PTYNERENLP LIVWLLVKSF
60 70 80 90 100
SESGINYEII IIDDGSPDGT RDIAEQLVKI YGSDKILLRP REKKLGLGTA
110 120 130 140 150
YIHGMKHATG NYIIIMDADL SHHPKFIPEF IRKQKEGNFD IVSGTRYKGN
160 170 180 190 200
GGVYGWDLKR KIISRGANFI TQILLRPGAS DLTGSFRLYR KEVLQKLIEK
210 220 230 240 250
CVSKGYVFQM EMIVRARQLN YTIGEVPISF VDRVYGESKL GGNEIVSFLK

GLLTLFATT
Length:259
Mass (Da):29,471
Last modified:June 12, 2007 - v1
Checksum:i01E6C2B72CF32B68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974565, CT009560 Genomic DNA Translation: CAN13124.1
CT009560, CR974565 Genomic DNA Translation: CAN13232.1
RefSeqiNP_001095290.1, NM_001101820.1
UniGeneiSsc.6692

Genome annotation databases

EnsembliENSSSCT00000040191; ENSSSCP00000055745; ENSSSCG00000034952
GeneIDi100124379
KEGGissc:100124379

Similar proteinsi

Entry informationi

Entry nameiDPM1_PIG
AccessioniPrimary (citable) accession number: A5GFZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health