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Protein

Dolichol-phosphate mannosyltransferase subunit 1

Gene

DPM1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.By similarity

Catalytic activityi

GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-SSC-162699. Synthesis of dolichyl-phosphate mannose.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichol-phosphate mannosyltransferase subunit 1 (EC:2.4.1.83)
Alternative name(s):
Dolichol-phosphate mannose synthase subunit 1
Short name:
DPM synthase subunit 1
Dolichyl-phosphate beta-D-mannosyltransferase subunit 1
Mannose-P-dolichol synthase subunit 1
Short name:
MPD synthase subunit 1
Gene namesi
Name:DPM1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 17

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 259258Dolichol-phosphate mannosyltransferase subunit 1PRO_0000296396Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiA5GFZ5.
PRIDEiA5GFZ5.

Expressioni

Gene expression databases

GenevisibleiA5GFZ5. SS.

Interactioni

Subunit structurei

Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007962.

Structurei

3D structure databases

ProteinModelPortaliA5GFZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.Curated

Phylogenomic databases

eggNOGiKOG2978. Eukaryota.
COG0463. LUCA.
GeneTreeiENSGT00550000075000.
HOGENOMiHOG000283250.
HOVERGENiHBG018967.
InParanoidiA5GFZ5.
KOiK00721.
OMAiTAYIHGF.
OrthoDBiEOG7W41CN.
TreeFamiTF105617.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5GFZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEEASRNS RSRWEPEGRF PRQDKYSVLL PTYNERENLP LIVWLLVKSF
60 70 80 90 100
SESGINYEII IIDDGSPDGT RDIAEQLVKI YGSDKILLRP REKKLGLGTA
110 120 130 140 150
YIHGMKHATG NYIIIMDADL SHHPKFIPEF IRKQKEGNFD IVSGTRYKGN
160 170 180 190 200
GGVYGWDLKR KIISRGANFI TQILLRPGAS DLTGSFRLYR KEVLQKLIEK
210 220 230 240 250
CVSKGYVFQM EMIVRARQLN YTIGEVPISF VDRVYGESKL GGNEIVSFLK

GLLTLFATT
Length:259
Mass (Da):29,471
Last modified:June 12, 2007 - v1
Checksum:i01E6C2B72CF32B68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974565, CT009560 Genomic DNA. Translation: CAN13124.1.
CT009560, CR974565 Genomic DNA. Translation: CAN13232.1.
RefSeqiNP_001095290.1. NM_001101820.1.
UniGeneiSsc.6692.

Genome annotation databases

EnsembliENSSSCT00000008179; ENSSSCP00000007962; ENSSSCG00000007474.
GeneIDi100124379.
KEGGissc:100124379.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974565, CT009560 Genomic DNA. Translation: CAN13124.1.
CT009560, CR974565 Genomic DNA. Translation: CAN13232.1.
RefSeqiNP_001095290.1. NM_001101820.1.
UniGeneiSsc.6692.

3D structure databases

ProteinModelPortaliA5GFZ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007962.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Proteomic databases

PaxDbiA5GFZ5.
PRIDEiA5GFZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000008179; ENSSSCP00000007962; ENSSSCG00000007474.
GeneIDi100124379.
KEGGissc:100124379.

Organism-specific databases

CTDi8813.

Phylogenomic databases

eggNOGiKOG2978. Eukaryota.
COG0463. LUCA.
GeneTreeiENSGT00550000075000.
HOGENOMiHOG000283250.
HOVERGENiHBG018967.
InParanoidiA5GFZ5.
KOiK00721.
OMAiTAYIHGF.
OrthoDBiEOG7W41CN.
TreeFamiTF105617.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiR-SSC-162699. Synthesis of dolichyl-phosphate mannose.

Gene expression databases

GenevisibleiA5GFZ5. SS.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Porcine genome sequencing project
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDPM1_PIG
AccessioniPrimary (citable) accession number: A5GFZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: November 11, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.