Reviewed, UniProtKB/Swiss-Prot A5GFY8 (SERA_PIG)

Names and origin

Protein names

Recommended name:
    D-3-phosphoglycerate dehydrogenase
      Short name=3-PGDH
    EC=1.1.1.95

Gene names

Name:

PHGDH

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	533 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-phospho-D-glycerate + NAD+ = 3-phosphonooxypyruvate + NADH. 2-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH.
Pathway	Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glyceric acid: step 1/3.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Serine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	L-serine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro phosphoglycerate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 533	532	D-3-phosphoglycerate dehydrogenase		PRO_0000318300
Sites
	Active site	236	1	By similarity
	Active site	265	1	By similarity
	Active site	283	1	Proton donor By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	371	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5GFY8-1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 2D80F1809E1579BE	FASTA	533	56,810
	10 20 30 40 50 60 MAFANLRKVL ISDSLDPCCR EILQDGGLQV VEKQNLSKEE LIAELQDCEG LIVRSATKVT 70 80 90 100 110 120 SDVINAAKKL QVVGRAGTGV DNVDLEAATR KGILVMNTPN GNSLSAAELT CGMILCLARQ 130 140 150 160 170 180 IPQATASMKD GKWERKKFMG TELNGKVLGI LGLGRIGREV ATRMQSFGMK TIGYDPIIAP 190 200 210 220 230 240 EVSASFGVQQ LPLEEIWPLC DFITVHTPLL PSTTGLLNDS TFALCKKGVR VVNCARGGIV 250 260 270 280 290 300 DEGALLRALQ SGQCAGAALD VFTEEPPRDR ALVDHEKVIS CPHLGASTRE AQSRCGEEIA 310 320 330 340 350 360 IQFVDMVKGR SLAGVVNAQA LTSAFSPHTK PWIGLAEALG ALMQAWAGSP KGTIQVVTQG 370 380 390 400 410 420 TSLKNSGTCL SPAVIVGLLK EASHRADVNL VNAKLLEKEA GLHVTTSHNP AAPEEQGGAE 430 440 450 460 470 480 CFLTVALAGA PYQAVGLVQG TAPMLHALNG AVFRPEVPLR RGLPLLLFRA QPSNPTMLPT 490 500 510 520 530 MIGLLAEARV QLLSYQTSVV SDGETWHVMA ISSLLPSLEP WKQHVTEAFQ FHF

References

[1]	Porcine genome sequencing project Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Duroc.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR956647 Genomic DNA. Translation: CAN13230.1.
RefSeq	NP_001116634.1.
UniGene	Ssc.21431
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	100144529.
KEGG	ssc:100144529.
Enzyme and pathway databases
BRENDA	1.1.1.95. 249.
Family and domain databases
InterPro	IPR006236. D-3-Phosphoglycerate_DH. IPR006139. D-isomer_2_OHA_DH. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR015508. D3PG_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR10996:SF20. D3PG_Deh. 1 hit.
Pfam	PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR01327. PGDH. 1 hit.
PROSITE	PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00670. D_2_HYDROXYACID_DH_2. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SERA_PIG

Accession

Primary (citable) accession number: A5GFY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 12, 2007
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)