SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A5GFT6

- TSH2_PIG

UniProt

A5GFT6 - TSH2_PIG

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Teashirt homolog 2
Gene
TSHZ2
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor Reviewed prediction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri216 – 24025C2H2-type 1
Add
BLAST
Zinc fingeri276 – 30025C2H2-type 2
Add
BLAST
Zinc fingeri381 – 40525C2H2-type 3; atypical
Add
BLAST
DNA bindingi842 – 91271Homeobox
Add
BLAST
Zinc fingeri927 – 94923C2H2-type 4
Add
BLAST
Zinc fingeri995 – 101824C2H2-type 5
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Teashirt homolog 2
Gene namesi
Name:TSHZ2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 17

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10351035Teashirt homolog 2
PRO_0000296391Add
BLAST

Post-translational modificationi

Sumoylated By similarity.

Keywords - PTMi

Ubl conjugation

Expressioni

Gene expression databases

ArrayExpressiA5GFT6.

Interactioni

Subunit structurei

Interacts (via homeobox domain) with APBB1 (via PID domain 1) By similarity.

Structurei

3D structure databases

ProteinModelPortaliA5GFT6.
SMRiA5GFT6. Positions 202-304.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili13 – 4230 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG45055.
GeneTreeiENSGT00390000014977.
HOGENOMiHOG000231480.
HOVERGENiHBG079626.
KOiK09236.
OrthoDBiEOG7NPFSF.
TreeFamiTF328447.

Family and domain databases

InterProiIPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR027010. Tshz2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR12487. PTHR12487. 1 hit.
PTHR12487:SF3. PTHR12487:SF3. 1 hit.
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5GFT6-1 [UniParc]FASTAAdd to Basket

« Hide

MPRRKQQAPK RAAGYAQEEQ LKEEEEIKEE EEEEEDSGSV AQLQGSNDPG     50
TDEELETGAE QKGCFSYQNS PGSHLSNQDA ENESLLSDAS DQVSDIKSVC 100
SRDASDKKAS VHPKLPTEAH SCMDKMTAVY ANILSDSYWS GLGLGFKLSS 150
SERRHCDTRN GSSKTDFDWH QDALSKSLQQ NLPPRSVSKP SLFSSVQLYR 200
QSSKMCGTVF TGASRFRCRQ CSAAYDTLVE LTVHMNETGH YQDDNRKKDK 250
LRPTSYSKPR KRAFQDMDKE DAQKVLKCMF CGDSFDSLQD LSVHMIKTKH 300
YQKVPLKEPV PTISSKMVTP AKKRVFDVNR PCSPDSTTGS FADPFPAPKN 350
ASLQLSSNNR YGYQNGASYT WQFEACKSQI LKCMECGSSH DTLQQLTTHM 400
MVTGHFLKVT SSASKKGKQL VLDPLAVEKM QSLSDAPSSD SLAPKPSSNS 450
ASDCTASTTE LKRESKKEKP EELRTDEKVL KSEDYEDPLQ KPLDPAMKYQ 500
YLREEDLEDG SKGGGDILKS LENTVTTAIN KAQNGAPSWS AYPSIHAAYQ 550
LSEGTKPSLP MGSQVLQIRP NLANKLRPIA PKWKVMPLVS VPTSLAPYTQ 600
VKKEPEDKEE VAKECGQESP HEEASSFSHS EGDSFPKSEP PAESKKAEPC 650
PLREEDKRMK DGGEKEKAQP VEPVSSLSNG CALAAHAPAP PCVNPLSALQ 700
SVLNNHLGKA TEPLRSPSCS SPSSSTMAMF HKSSLGVMDK PVLSPASTRP 750
ASVSRRYLFE NNDQPIDLTK SKSKKAESSQ AQSCTSPPQK HALSDIADMV 800
KVLPKATTPK PAASSRVPPV KLEMDVRRFE DVSSEVSTLH KRKGRQSNWN 850
PQHLLILQAQ FASSLFQTSE GKYLLSDLGP QERMQISKFT GLSMTTISHW 900
LANVKYQLRK TGGTKFLKNM DKGHPIFYCS DCASQFRTPS TYISHLESHL 950
GFQMKDMTRM AVEQQSQVEQ EISRVSSAQR SPETIAGEED TDSKFKCKLC 1000
CRTFVSKHAV KLHLSKTHSK SPEHHAQFVT DVDEE 1035
Length:1,035
Mass (Da):114,602
Last modified:June 12, 2007 - v1
Checksum:iB2243190681D354C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR974445, CR956408 Genomic DNA. Translation: CAN13183.1.
CR956408, CR974445 Genomic DNA. Translation: CAN13227.1.
RefSeqiNP_001108146.1. NM_001114674.1.
UniGeneiSsc.47308.

Genome annotation databases

EnsembliENSSSCT00000034759; ENSSSCP00000030054; ENSSSCG00000007482.
GeneIDi100136903.
KEGGissc:100136903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR974445 , CR956408 Genomic DNA. Translation: CAN13183.1 .
CR956408 , CR974445 Genomic DNA. Translation: CAN13227.1 .
RefSeqi NP_001108146.1. NM_001114674.1.
UniGenei Ssc.47308.

3D structure databases

ProteinModelPortali A5GFT6.
SMRi A5GFT6. Positions 202-304.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000034759 ; ENSSSCP00000030054 ; ENSSSCG00000007482 .
GeneIDi 100136903.
KEGGi ssc:100136903.

Organism-specific databases

CTDi 128553.

Phylogenomic databases

eggNOGi NOG45055.
GeneTreei ENSGT00390000014977.
HOGENOMi HOG000231480.
HOVERGENi HBG079626.
KOi K09236.
OrthoDBi EOG7NPFSF.
TreeFami TF328447.

Gene expression databases

ArrayExpressi A5GFT6.

Family and domain databases

InterProi IPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR027010. Tshz2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
PANTHERi PTHR12487. PTHR12487. 1 hit.
PTHR12487:SF3. PTHR12487:SF3. 1 hit.
SMARTi SM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Porcine genome sequencing project
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTSH2_PIG
AccessioniPrimary (citable) accession number: A5GFT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi