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A5GFT6 (TSH2_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Teashirt homolog 2
Gene names
Name:TSHZ2
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length1035 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor Potential.

Subunit structure

Interacts (via homeobox domain) with APBB1 (via PID domain 1) By similarity.

Subcellular location

Nucleus Probable.

Post-translational modification

Sumoylated By similarity.

Sequence similarities

Belongs to the teashirt C2H2-type zinc-finger protein family.

Contains 5 C2H2-type zinc fingers.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10351035Teashirt homolog 2
PRO_0000296391

Regions

Zinc finger216 – 24025C2H2-type 1
Zinc finger276 – 30025C2H2-type 2
Zinc finger381 – 40525C2H2-type 3; atypical
DNA binding842 – 91271Homeobox
Zinc finger927 – 94923C2H2-type 4
Zinc finger995 – 101824C2H2-type 5
Coiled coil13 – 4230 Potential

Sequences

Sequence LengthMass (Da)Tools
A5GFT6 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: B2243190681D354C

FASTA1,035114,602
        10         20         30         40         50         60 
MPRRKQQAPK RAAGYAQEEQ LKEEEEIKEE EEEEEDSGSV AQLQGSNDPG TDEELETGAE 

        70         80         90        100        110        120 
QKGCFSYQNS PGSHLSNQDA ENESLLSDAS DQVSDIKSVC SRDASDKKAS VHPKLPTEAH 

       130        140        150        160        170        180 
SCMDKMTAVY ANILSDSYWS GLGLGFKLSS SERRHCDTRN GSSKTDFDWH QDALSKSLQQ 

       190        200        210        220        230        240 
NLPPRSVSKP SLFSSVQLYR QSSKMCGTVF TGASRFRCRQ CSAAYDTLVE LTVHMNETGH 

       250        260        270        280        290        300 
YQDDNRKKDK LRPTSYSKPR KRAFQDMDKE DAQKVLKCMF CGDSFDSLQD LSVHMIKTKH 

       310        320        330        340        350        360 
YQKVPLKEPV PTISSKMVTP AKKRVFDVNR PCSPDSTTGS FADPFPAPKN ASLQLSSNNR 

       370        380        390        400        410        420 
YGYQNGASYT WQFEACKSQI LKCMECGSSH DTLQQLTTHM MVTGHFLKVT SSASKKGKQL 

       430        440        450        460        470        480 
VLDPLAVEKM QSLSDAPSSD SLAPKPSSNS ASDCTASTTE LKRESKKEKP EELRTDEKVL 

       490        500        510        520        530        540 
KSEDYEDPLQ KPLDPAMKYQ YLREEDLEDG SKGGGDILKS LENTVTTAIN KAQNGAPSWS 

       550        560        570        580        590        600 
AYPSIHAAYQ LSEGTKPSLP MGSQVLQIRP NLANKLRPIA PKWKVMPLVS VPTSLAPYTQ 

       610        620        630        640        650        660 
VKKEPEDKEE VAKECGQESP HEEASSFSHS EGDSFPKSEP PAESKKAEPC PLREEDKRMK 

       670        680        690        700        710        720 
DGGEKEKAQP VEPVSSLSNG CALAAHAPAP PCVNPLSALQ SVLNNHLGKA TEPLRSPSCS 

       730        740        750        760        770        780 
SPSSSTMAMF HKSSLGVMDK PVLSPASTRP ASVSRRYLFE NNDQPIDLTK SKSKKAESSQ 

       790        800        810        820        830        840 
AQSCTSPPQK HALSDIADMV KVLPKATTPK PAASSRVPPV KLEMDVRRFE DVSSEVSTLH 

       850        860        870        880        890        900 
KRKGRQSNWN PQHLLILQAQ FASSLFQTSE GKYLLSDLGP QERMQISKFT GLSMTTISHW 

       910        920        930        940        950        960 
LANVKYQLRK TGGTKFLKNM DKGHPIFYCS DCASQFRTPS TYISHLESHL GFQMKDMTRM 

       970        980        990       1000       1010       1020 
AVEQQSQVEQ EISRVSSAQR SPETIAGEED TDSKFKCKLC CRTFVSKHAV KLHLSKTHSK 

      1030 
SPEHHAQFVT DVDEE 

« Hide

References

[1]Porcine genome sequencing project
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR974445, CR956408 Genomic DNA. Translation: CAN13183.1.
CR956408, CR974445 Genomic DNA. Translation: CAN13227.1.
RefSeqNP_001108146.1. NM_001114674.1.
UniGeneSsc.47308.

3D structure databases

ProteinModelPortalA5GFT6.
SMRA5GFT6. Positions 202-304.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000034759; ENSSSCP00000030054; ENSSSCG00000007482.
GeneID100136903.
KEGGssc:100136903.

Organism-specific databases

CTD128553.

Phylogenomic databases

eggNOGNOG45055.
GeneTreeENSGT00390000014977.
HOGENOMHOG000231480.
HOVERGENHBG079626.
KOK09236.
OrthoDBEOG7NPFSF.
TreeFamTF328447.

Gene expression databases

ArrayExpressA5GFT6.

Family and domain databases

InterProIPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR027010. Tshz2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERPTHR12487. PTHR12487. 1 hit.
PTHR12487:SF3. PTHR12487:SF3. 1 hit.
SMARTSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTSH2_PIG
AccessionPrimary (citable) accession number: A5GFT6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families