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A5GFT6

- TSH2_PIG

UniProt

A5GFT6 - TSH2_PIG

Protein

Teashirt homolog 2

Gene

TSHZ2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor Potential.Curated

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri216 – 24025C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri276 – 30025C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri381 – 40525C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi842 – 91271HomeoboxAdd
    BLAST
    Zinc fingeri927 – 94923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri995 – 101824C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Teashirt homolog 2
    Gene namesi
    Name:TSHZ2
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 17

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10351035Teashirt homolog 2PRO_0000296391Add
    BLAST

    Post-translational modificationi

    Sumoylated.By similarity

    Keywords - PTMi

    Ubl conjugation

    Expressioni

    Gene expression databases

    ArrayExpressiA5GFT6.

    Interactioni

    Subunit structurei

    Interacts (via homeobox domain) with APBB1 (via PID domain 1).By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA5GFT6.
    SMRiA5GFT6. Positions 202-304.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili13 – 4230Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 homeobox DNA-binding domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri216 – 24025C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri276 – 30025C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri381 – 40525C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri927 – 94923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri995 – 101824C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Homeobox, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG45055.
    GeneTreeiENSGT00390000014977.
    HOGENOMiHOG000231480.
    HOVERGENiHBG079626.
    KOiK09236.
    OrthoDBiEOG7NPFSF.
    TreeFamiTF328447.

    Family and domain databases

    InterProiIPR001356. Homeobox_dom.
    IPR027008. Teashirt_fam.
    IPR027010. Tshz2.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PANTHERiPTHR12487. PTHR12487. 1 hit.
    PTHR12487:SF3. PTHR12487:SF3. 1 hit.
    SMARTiSM00389. HOX. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5GFT6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRRKQQAPK RAAGYAQEEQ LKEEEEIKEE EEEEEDSGSV AQLQGSNDPG     50
    TDEELETGAE QKGCFSYQNS PGSHLSNQDA ENESLLSDAS DQVSDIKSVC 100
    SRDASDKKAS VHPKLPTEAH SCMDKMTAVY ANILSDSYWS GLGLGFKLSS 150
    SERRHCDTRN GSSKTDFDWH QDALSKSLQQ NLPPRSVSKP SLFSSVQLYR 200
    QSSKMCGTVF TGASRFRCRQ CSAAYDTLVE LTVHMNETGH YQDDNRKKDK 250
    LRPTSYSKPR KRAFQDMDKE DAQKVLKCMF CGDSFDSLQD LSVHMIKTKH 300
    YQKVPLKEPV PTISSKMVTP AKKRVFDVNR PCSPDSTTGS FADPFPAPKN 350
    ASLQLSSNNR YGYQNGASYT WQFEACKSQI LKCMECGSSH DTLQQLTTHM 400
    MVTGHFLKVT SSASKKGKQL VLDPLAVEKM QSLSDAPSSD SLAPKPSSNS 450
    ASDCTASTTE LKRESKKEKP EELRTDEKVL KSEDYEDPLQ KPLDPAMKYQ 500
    YLREEDLEDG SKGGGDILKS LENTVTTAIN KAQNGAPSWS AYPSIHAAYQ 550
    LSEGTKPSLP MGSQVLQIRP NLANKLRPIA PKWKVMPLVS VPTSLAPYTQ 600
    VKKEPEDKEE VAKECGQESP HEEASSFSHS EGDSFPKSEP PAESKKAEPC 650
    PLREEDKRMK DGGEKEKAQP VEPVSSLSNG CALAAHAPAP PCVNPLSALQ 700
    SVLNNHLGKA TEPLRSPSCS SPSSSTMAMF HKSSLGVMDK PVLSPASTRP 750
    ASVSRRYLFE NNDQPIDLTK SKSKKAESSQ AQSCTSPPQK HALSDIADMV 800
    KVLPKATTPK PAASSRVPPV KLEMDVRRFE DVSSEVSTLH KRKGRQSNWN 850
    PQHLLILQAQ FASSLFQTSE GKYLLSDLGP QERMQISKFT GLSMTTISHW 900
    LANVKYQLRK TGGTKFLKNM DKGHPIFYCS DCASQFRTPS TYISHLESHL 950
    GFQMKDMTRM AVEQQSQVEQ EISRVSSAQR SPETIAGEED TDSKFKCKLC 1000
    CRTFVSKHAV KLHLSKTHSK SPEHHAQFVT DVDEE 1035
    Length:1,035
    Mass (Da):114,602
    Last modified:June 12, 2007 - v1
    Checksum:iB2243190681D354C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR974445, CR956408 Genomic DNA. Translation: CAN13183.1.
    CR956408, CR974445 Genomic DNA. Translation: CAN13227.1.
    RefSeqiNP_001108146.1. NM_001114674.1.
    UniGeneiSsc.47308.

    Genome annotation databases

    EnsembliENSSSCT00000034759; ENSSSCP00000030054; ENSSSCG00000007482.
    GeneIDi100136903.
    KEGGissc:100136903.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR974445 , CR956408 Genomic DNA. Translation: CAN13183.1 .
    CR956408 , CR974445 Genomic DNA. Translation: CAN13227.1 .
    RefSeqi NP_001108146.1. NM_001114674.1.
    UniGenei Ssc.47308.

    3D structure databases

    ProteinModelPortali A5GFT6.
    SMRi A5GFT6. Positions 202-304.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000034759 ; ENSSSCP00000030054 ; ENSSSCG00000007482 .
    GeneIDi 100136903.
    KEGGi ssc:100136903.

    Organism-specific databases

    CTDi 128553.

    Phylogenomic databases

    eggNOGi NOG45055.
    GeneTreei ENSGT00390000014977.
    HOGENOMi HOG000231480.
    HOVERGENi HBG079626.
    KOi K09236.
    OrthoDBi EOG7NPFSF.
    TreeFami TF328447.

    Gene expression databases

    ArrayExpressi A5GFT6.

    Family and domain databases

    InterProi IPR001356. Homeobox_dom.
    IPR027008. Teashirt_fam.
    IPR027010. Tshz2.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    PANTHERi PTHR12487. PTHR12487. 1 hit.
    PTHR12487:SF3. PTHR12487:SF3. 1 hit.
    SMARTi SM00389. HOX. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Porcine genome sequencing project
      Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiTSH2_PIG
    AccessioniPrimary (citable) accession number: A5GFT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3