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A5GFT6

- TSH2_PIG

UniProt

A5GFT6 - TSH2_PIG

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Protein

Teashirt homolog 2

Gene

TSHZ2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri216 – 24025C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 30025C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40525C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
DNA bindingi842 – 91271HomeoboxAdd
BLAST
Zinc fingeri927 – 94923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri995 – 101824C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Teashirt homolog 2
Gene namesi
Name:TSHZ2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 17

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10351035Teashirt homolog 2PRO_0000296391Add
BLAST

Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Ubl conjugation

Interactioni

Subunit structurei

Interacts (via homeobox domain) with APBB1 (via PID domain 1).By similarity

Structurei

3D structure databases

ProteinModelPortaliA5GFT6.
SMRiA5GFT6. Positions 202-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili13 – 4230Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri216 – 24025C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 30025C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40525C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri927 – 94923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri995 – 101824C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG45055.
GeneTreeiENSGT00390000014977.
HOGENOMiHOG000231480.
HOVERGENiHBG079626.
InParanoidiA5GFT6.
KOiK09236.
OrthoDBiEOG7NPFSF.
TreeFamiTF328447.

Family and domain databases

InterProiIPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR027010. Tshz2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR12487. PTHR12487. 1 hit.
PTHR12487:SF3. PTHR12487:SF3. 1 hit.
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5GFT6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRRKQQAPK RAAGYAQEEQ LKEEEEIKEE EEEEEDSGSV AQLQGSNDPG
60 70 80 90 100
TDEELETGAE QKGCFSYQNS PGSHLSNQDA ENESLLSDAS DQVSDIKSVC
110 120 130 140 150
SRDASDKKAS VHPKLPTEAH SCMDKMTAVY ANILSDSYWS GLGLGFKLSS
160 170 180 190 200
SERRHCDTRN GSSKTDFDWH QDALSKSLQQ NLPPRSVSKP SLFSSVQLYR
210 220 230 240 250
QSSKMCGTVF TGASRFRCRQ CSAAYDTLVE LTVHMNETGH YQDDNRKKDK
260 270 280 290 300
LRPTSYSKPR KRAFQDMDKE DAQKVLKCMF CGDSFDSLQD LSVHMIKTKH
310 320 330 340 350
YQKVPLKEPV PTISSKMVTP AKKRVFDVNR PCSPDSTTGS FADPFPAPKN
360 370 380 390 400
ASLQLSSNNR YGYQNGASYT WQFEACKSQI LKCMECGSSH DTLQQLTTHM
410 420 430 440 450
MVTGHFLKVT SSASKKGKQL VLDPLAVEKM QSLSDAPSSD SLAPKPSSNS
460 470 480 490 500
ASDCTASTTE LKRESKKEKP EELRTDEKVL KSEDYEDPLQ KPLDPAMKYQ
510 520 530 540 550
YLREEDLEDG SKGGGDILKS LENTVTTAIN KAQNGAPSWS AYPSIHAAYQ
560 570 580 590 600
LSEGTKPSLP MGSQVLQIRP NLANKLRPIA PKWKVMPLVS VPTSLAPYTQ
610 620 630 640 650
VKKEPEDKEE VAKECGQESP HEEASSFSHS EGDSFPKSEP PAESKKAEPC
660 670 680 690 700
PLREEDKRMK DGGEKEKAQP VEPVSSLSNG CALAAHAPAP PCVNPLSALQ
710 720 730 740 750
SVLNNHLGKA TEPLRSPSCS SPSSSTMAMF HKSSLGVMDK PVLSPASTRP
760 770 780 790 800
ASVSRRYLFE NNDQPIDLTK SKSKKAESSQ AQSCTSPPQK HALSDIADMV
810 820 830 840 850
KVLPKATTPK PAASSRVPPV KLEMDVRRFE DVSSEVSTLH KRKGRQSNWN
860 870 880 890 900
PQHLLILQAQ FASSLFQTSE GKYLLSDLGP QERMQISKFT GLSMTTISHW
910 920 930 940 950
LANVKYQLRK TGGTKFLKNM DKGHPIFYCS DCASQFRTPS TYISHLESHL
960 970 980 990 1000
GFQMKDMTRM AVEQQSQVEQ EISRVSSAQR SPETIAGEED TDSKFKCKLC
1010 1020 1030
CRTFVSKHAV KLHLSKTHSK SPEHHAQFVT DVDEE
Length:1,035
Mass (Da):114,602
Last modified:June 12, 2007 - v1
Checksum:iB2243190681D354C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR974445, CR956408 Genomic DNA. Translation: CAN13183.1.
CR956408, CR974445 Genomic DNA. Translation: CAN13227.1.
RefSeqiNP_001108146.1. NM_001114674.1.
UniGeneiSsc.47308.

Genome annotation databases

EnsembliENSSSCT00000034759; ENSSSCP00000030054; ENSSSCG00000007482.
GeneIDi100136903.
KEGGissc:100136903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR974445 , CR956408 Genomic DNA. Translation: CAN13183.1 .
CR956408 , CR974445 Genomic DNA. Translation: CAN13227.1 .
RefSeqi NP_001108146.1. NM_001114674.1.
UniGenei Ssc.47308.

3D structure databases

ProteinModelPortali A5GFT6.
SMRi A5GFT6. Positions 202-304.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000034759 ; ENSSSCP00000030054 ; ENSSSCG00000007482 .
GeneIDi 100136903.
KEGGi ssc:100136903.

Organism-specific databases

CTDi 128553.

Phylogenomic databases

eggNOGi NOG45055.
GeneTreei ENSGT00390000014977.
HOGENOMi HOG000231480.
HOVERGENi HBG079626.
InParanoidi A5GFT6.
KOi K09236.
OrthoDBi EOG7NPFSF.
TreeFami TF328447.

Family and domain databases

InterProi IPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR027010. Tshz2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
PANTHERi PTHR12487. PTHR12487. 1 hit.
PTHR12487:SF3. PTHR12487:SF3. 1 hit.
SMARTi SM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Porcine genome sequencing project
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTSH2_PIG
AccessioniPrimary (citable) accession number: A5GFT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3