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A5GF91

- PNP_GEOUR

UniProt

A5GF91 - PNP_GEOUR

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, Gura_1906
Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi483 – 4831Magnesium By similarity
Metal bindingi489 – 4891Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciGURA351605:GI6A-1927-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Gura_1906
OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Taxonomic identifieri351605 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000006695: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696696Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_0000329663Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351605.Gura_1906.

Structurei

3D structure databases

ProteinModelPortaliA5GF91.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini550 – 60960KHAdd
BLAST
Domaini619 – 68769S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiHGNFKSN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5GF91-1 [UniParc]FASTAAdd to Basket

« Hide

METKVQVEFG GRTITIETGK MAKQASGAVV VSSGDTMVLV TAVATKTAKE    50
GQDFFPLTVN YQEKAYAGGK IPGGFFKREA RPSDNETLTC RLIDRPIRPL 100
FPENFLNDTQ IMATVVSADK DNDPGILSMV GASAALMVSD IPFQGPIAGV 150
KVGRVDGRFI ANPTADEMEK SDIEIVVAAS KDAVIMVEGS AAEVSEEDML 200
EAIFFGHAAI QPLLAAQEEL CSKAGVAKRE VPPPAVNEEL KANVKDIAYA 250
RMKEAVRIKS KVERHNSIDA ISAETLAALA TEFEGCDKQI KAFLGDFEYE 300
LVREHILKDG ERIDGRDTKT IRQITTEVSL LPRAHGSALF TRGETQSLVA 350
ATLGTSIDEQ RIDSLFGESK KRFLLHYNFP PFSVGETSFR LGPGRREIGH 400
GMLAERALAR VLPKHDDFPY TIRIVSDILE SNGSSSMASV CGGSMSMMDA 450
GIPIKAPVAG IAMGLIKEGE DFAILSDILG DEDHLGDMDF KVAGTAEGVT 500
ALQMDIKIGG VTREIMGIAL KQALEGRLHI LGRMADTIKT SKSDLSTYAP 550
RITTIYVKTD KIRDVIGSGG KNIRGITEAT GVTIDIDDTG KINIASTDKA 600
ACDLAIKMIR DLTAEAEEGK LYMGLVKKVM EFGAFVEIFP GTDGLVHISE 650
LDTERVKNVT DILKEGDKVL VKCIGIDKQG KIKLSRKEAL GATLPE 696
Length:696
Mass (Da):75,018
Last modified:June 12, 2007 - v1
Checksum:iC42E3AE53946EC2A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000698 Genomic DNA. Translation: ABQ26096.1.
RefSeqiYP_001230669.1. NC_009483.1.

Genome annotation databases

EnsemblBacteriaiABQ26096; ABQ26096; Gura_1906.
GeneIDi5167024.
KEGGigur:Gura_1906.
PATRICi22033912. VBIGeoUra13052_2037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000698 Genomic DNA. Translation: ABQ26096.1 .
RefSeqi YP_001230669.1. NC_009483.1.

3D structure databases

ProteinModelPortali A5GF91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351605.Gura_1906.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ26096 ; ABQ26096 ; Gura_1906 .
GeneIDi 5167024.
KEGGi gur:Gura_1906.
PATRICi 22033912. VBIGeoUra13052_2037.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi HGNFKSN.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci GURA351605:GI6A-1927-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rf4.

Entry informationi

Entry nameiPNP_GEOUR
AccessioniPrimary (citable) accession number: A5GF91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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