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Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (Gura_1734)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94Anthranilate 1; via carbonyl oxygenUniRule annotation1
Binding sitei94Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei102PhosphoribosylpyrophosphateUniRule annotation1
Metal bindingi106Magnesium 1UniRule annotation1
Binding sitei125Anthranilate 1UniRule annotation1
Binding sitei134Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei180Anthranilate 2UniRule annotation1
Metal bindingi239Magnesium 2UniRule annotation1
Metal bindingi240Magnesium 1UniRule annotation1
Metal bindingi240Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:Gura_1733
OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Taxonomic identifieri351605 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000006695 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000780151 – 350Anthranilate phosphoribosyltransferaseAdd BLAST350

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi351605.Gura_1733.

Structurei

3D structure databases

ProteinModelPortaliA5GES2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 98Phosphoribosylpyrophosphate bindingUniRule annotation2
Regioni104 – 107Phosphoribosylpyrophosphate bindingUniRule annotation4
Regioni122 – 130Phosphoribosylpyrophosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiMIVLNAG.
OrthoDBiPOG091H01QX.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

A5GES2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKKAIAKVV EREDLTESEM IQVMDQVMSG EATPAQIAAF ITALRMKGET
60 70 80 90 100
VAEITGAARV MRDKVTRIRV GKNILDMDRD DINVDLETIL DTCGTGGSCT
110 120 130 140 150
NTFNVSTTVA FVVSACGVKV AKHGNRSVSS ACGSADVLES LGVNLDVTQE
160 170 180 190 200
TIERCINEIG IGFLFAPALH GAMKYAIGPR KEIGIRTIFN ILGPLTNPAG
210 220 230 240 250
AGCQVLGVYR EDLVEKLAHV LKNLGCKRGF VVHGQDGMDE MTLTAETRIA
260 270 280 290 300
EVTPAGVATR LFRPEELGLS RCGMDDLRGG DAAANAVIVR RVLEGEKGPK
310 320 330 340 350
RDIVLLNAAF GLVAAGRVVD PAAGLTMAAE AIDSGKALAQ LEKLVKLTNE
Length:350
Mass (Da):37,107
Last modified:June 12, 2007 - v1
Checksum:iB9757C280CA6E425
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA. Translation: ABQ25927.1.
RefSeqiWP_011938633.1. NC_009483.1.

Genome annotation databases

EnsemblBacteriaiABQ25927; ABQ25927; Gura_1733.
KEGGigur:Gura_1733.
PATRICi22033565. VBIGeoUra13052_1864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA. Translation: ABQ25927.1.
RefSeqiWP_011938633.1. NC_009483.1.

3D structure databases

ProteinModelPortaliA5GES2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351605.Gura_1733.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ25927; ABQ25927; Gura_1733.
KEGGigur:Gura_1733.
PATRICi22033565. VBIGeoUra13052_1864.

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiMIVLNAG.
OrthoDBiPOG091H01QX.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPD_GEOUR
AccessioniPrimary (citable) accession number: A5GES2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.