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A5GDG7 (HEMH_GEOUR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Gura_0173
OrganismGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens) [Complete proteome] [HAMAP]
Taxonomic identifier351605 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Ferrochelatase HAMAP MF_00323
PRO_1000079196

Sites

Metal binding1921Iron By similarity
Metal binding2711Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A5GDG7 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: DA81B6784D131197

FASTA31935,778
        10         20         30         40         50         60 
MPEKTAVLLL QMGGPDSIEA VEPFLLNLFS DREIIKIGPA FLQPFIARRI CRKRAPKVEG 

        70         80         90        100        110        120 
YYSQIGGKSP IRELTEAQAQ ALEEKLGGNF RCFVAMRYWK PTTIDALAAI KREGISRVIA 

       130        140        150        160        170        180 
LSLYPHYSRA TTGSSINELK RVLGEAGARF EVSYVDRFYD HPLYIAALAA KIEEGLAQFS 

       190        200        210        220        230        240 
NRSEVELVFS AHSLPQSFID EGDPYLSHIL ETVRLVMERL GNVNYHLAFQ SRAGPVKWLE 

       250        260        270        280        290        300 
PSTEEMIQKL AKGGCKELLM VPLSFVSDHI ETLYEIDIQY AEEAKGLGIE HFRRSPSLNT 

       310 
SPLFIDCLAN LVHKTVSSE

« Hide

References

[1]"Complete sequence of Geobacter uraniireducens Rf4."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Shelobolina E., Aklujkar M., Lovley D., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rf4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000698 Genomic DNA. Translation: ABQ24389.1.
RefSeqYP_001228962.1. NC_009483.1.

3D structure databases

ProteinModelPortalA5GDG7.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5GDG7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5166416.
GenomeReviewsGene locus Gura_0173 in contig CP000698_GR.
KEGGgur:Gura_0173.
NMPDRfig|351605.3.peg.3460.
PATRIC22030154. VBIGeoUra13052_0177.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALLQMGGP.
ProtClustDBCLSK790160.

Enzyme and pathway databases

BioCycGURA351605:GURA_0173-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_GEOUR
AccessionPrimary (citable) accession number: A5GDG7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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