Reviewed, UniProtKB/Swiss-Prot A5GCZ8 (GCSPA_GEOUR)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	Gura_0337

Organism

Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens) [Complete proteome] [HAMAP]

Taxonomic identifier

351605 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000083222

Sequences

	Sequence		Length	Mass (Da)
	A5GCZ8-1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 7E815ADAE2A70EEF	FASTA	442	47,142
	10 20 30 40 50 60 MSYCPNTPED IREMLAAIGV ASVDALFAPI PAGLRARSFA LPDGTSEQEL LRQMKQLAGT 70 80 90 100 110 120 DRPVTGFIGG GYYDHYIPAV VDHLSGRAEF YTAYTPYQPE CSQGTLQALF EYQTAICRLT 130 140 150 160 170 180 GMEVSNASLY DGGTALAEAA MMALRVTGRN RLVIDGSVNP FSREIVRTYL TNLGVEIVEI 190 200 210 220 230 240 PARDGLADRP ALTAALTDLT AAVILQNPNF FGSVEDLSDI ALTAHANGAL LIASVYPISL 250 260 270 280 290 300 GLVKSPGAMG ADIVVGDGQS LGNPLSFGGP SFGFIATTKK YIRNLPGRII GETVDKSGRR 310 320 330 340 350 360 GFVLTLQARE QHIKRHKATS NICSNQSLCA LRGMIFLASV GKEGLVDLAR LNRDKAEYAK 370 380 390 400 410 420 GLLGSIKGVK LLNTAPTFNE FTIVLPKDAA EVAERLLGKG VAAGVPLGAY YHGMDNCLVV 430 440 TVTEKRTRDE IDALAKELEG AL

References

[1]

"Complete sequence of Geobacter uraniireducens Rf4." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Shelobolina E., Aklujkar M., Lovley D., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000698 Genomic DNA. Translation: ABQ24553.1.
RefSeq	YP_001229126.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5165879.
GenomeReviews	Gene locus Gura_0337 in contig CP000698_GR.
KEGG	gur:Gura_0337.
NMPDR	fig|351605.3.peg.1036.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A5GCZ8. VANASMY.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_GEOUR

Accession

Primary (citable) accession number: A5GCZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	June 12, 2007
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)