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A5GCZ8 (GCSPA_GEOUR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Gura_0337
OrganismGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens) [Complete proteome] [HAMAP]
Taxonomic identifier351605 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000083222

Sequences

Sequence LengthMass (Da)Tools
A5GCZ8 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 7E815ADAE2A70EEF

FASTA44247,142
        10         20         30         40         50         60 
MSYCPNTPED IREMLAAIGV ASVDALFAPI PAGLRARSFA LPDGTSEQEL LRQMKQLAGT 

        70         80         90        100        110        120 
DRPVTGFIGG GYYDHYIPAV VDHLSGRAEF YTAYTPYQPE CSQGTLQALF EYQTAICRLT 

       130        140        150        160        170        180 
GMEVSNASLY DGGTALAEAA MMALRVTGRN RLVIDGSVNP FSREIVRTYL TNLGVEIVEI 

       190        200        210        220        230        240 
PARDGLADRP ALTAALTDLT AAVILQNPNF FGSVEDLSDI ALTAHANGAL LIASVYPISL 

       250        260        270        280        290        300 
GLVKSPGAMG ADIVVGDGQS LGNPLSFGGP SFGFIATTKK YIRNLPGRII GETVDKSGRR 

       310        320        330        340        350        360 
GFVLTLQARE QHIKRHKATS NICSNQSLCA LRGMIFLASV GKEGLVDLAR LNRDKAEYAK 

       370        380        390        400        410        420 
GLLGSIKGVK LLNTAPTFNE FTIVLPKDAA EVAERLLGKG VAAGVPLGAY YHGMDNCLVV 

       430        440 
TVTEKRTRDE IDALAKELEG AL 

« Hide

References

[1]"Complete sequence of Geobacter uraniireducens Rf4."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Shelobolina E., Aklujkar M., Lovley D., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rf4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000698 Genomic DNA. Translation: ABQ24553.1.
RefSeqYP_001229126.1. NC_009483.1.

3D structure databases

ProteinModelPortalA5GCZ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING351605.Gura_0337.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ24553; ABQ24553; Gura_0337.
GeneID5165879.
KEGGgur:Gura_0337.
PATRIC22030512. VBIGeoUra13052_0352.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMALPMHASE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycGURA351605:GI6A-343-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_GEOUR
AccessionPrimary (citable) accession number: A5GCZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families