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A5GCZ8

- GCSPA_GEOUR

UniProt

A5GCZ8 - GCSPA_GEOUR

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciGURA351605:GI6A-343-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:Gura_0337
    OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
    Taxonomic identifieri351605 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000006695: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000083222Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi351605.Gura_0337.

    Structurei

    3D structure databases

    ProteinModelPortaliA5GCZ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiLPMHASE.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5GCZ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYCPNTPED IREMLAAIGV ASVDALFAPI PAGLRARSFA LPDGTSEQEL    50
    LRQMKQLAGT DRPVTGFIGG GYYDHYIPAV VDHLSGRAEF YTAYTPYQPE 100
    CSQGTLQALF EYQTAICRLT GMEVSNASLY DGGTALAEAA MMALRVTGRN 150
    RLVIDGSVNP FSREIVRTYL TNLGVEIVEI PARDGLADRP ALTAALTDLT 200
    AAVILQNPNF FGSVEDLSDI ALTAHANGAL LIASVYPISL GLVKSPGAMG 250
    ADIVVGDGQS LGNPLSFGGP SFGFIATTKK YIRNLPGRII GETVDKSGRR 300
    GFVLTLQARE QHIKRHKATS NICSNQSLCA LRGMIFLASV GKEGLVDLAR 350
    LNRDKAEYAK GLLGSIKGVK LLNTAPTFNE FTIVLPKDAA EVAERLLGKG 400
    VAAGVPLGAY YHGMDNCLVV TVTEKRTRDE IDALAKELEG AL 442
    Length:442
    Mass (Da):47,142
    Last modified:June 12, 2007 - v1
    Checksum:i7E815ADAE2A70EEF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000698 Genomic DNA. Translation: ABQ24553.1.
    RefSeqiWP_011937279.1. NC_009483.1.
    YP_001229126.1. NC_009483.1.

    Genome annotation databases

    EnsemblBacteriaiABQ24553; ABQ24553; Gura_0337.
    GeneIDi5165879.
    KEGGigur:Gura_0337.
    PATRICi22030512. VBIGeoUra13052_0352.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000698 Genomic DNA. Translation: ABQ24553.1 .
    RefSeqi WP_011937279.1. NC_009483.1.
    YP_001229126.1. NC_009483.1.

    3D structure databases

    ProteinModelPortali A5GCZ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351605.Gura_0337.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ24553 ; ABQ24553 ; Gura_0337 .
    GeneIDi 5165879.
    KEGGi gur:Gura_0337.
    PATRICi 22030512. VBIGeoUra13052_0352.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi LPMHASE.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci GURA351605:GI6A-343-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rf4.

    Entry informationi

    Entry nameiGCSPA_GEOUR
    AccessioniPrimary (citable) accession number: A5GCZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3