A5GCZ5 (NUOA1_GEOUR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-quinone oxidoreductase subunit A 1
EC=1.6.99.5

Alternative name(s):
NADH dehydrogenase I subunit A 1
NDH-1 subunit A 1
NUO1 1

Gene names

Name:	nuoA1
Ordered Locus Names:	Gura_0334

Organism

Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens) [Complete proteome] [HAMAP]

Taxonomic identifier

351605 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01394
Catalytic activity	NADH + quinone = NAD+ + quinol. HAMAP MF_01394
Subunit structure	NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01394.
Sequence similarities	Belongs to the complex I subunit 3 family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	NADH-quinone oxidoreductase subunit A 1 HAMAP MF_01394		PRO_0000362695
Regions
	Transmembrane	18 – 38	21	Helical; Potential
	Transmembrane	71 – 91	21	Helical; Potential
	Transmembrane	104 – 124	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A5GCZ5 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: C4CC394926134102	FASTA	145	16,120
	10 20 30 40 50 60 MSMSTPQKAI LPPFNADILP LGLYVAATVL LIGILLLAAW WLGDKKRSAA KEIAYESGVI 70 80 90 100 110 120 PTGTARLAYP VPFYLVAIFF IVFDVEAVFI FTWAVAWDEL GFPGLIHITA FIIVLLLGLV 130 140 WLWLKGGLEW GPSKQVRRSK FEVRS

References

[1]

"Complete sequence of Geobacter uraniireducens Rf4." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Shelobolina E., Aklujkar M., Lovley D., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rf4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000698 Genomic DNA. Translation: ABQ24550.1.
RefSeq	YP_001229123.1. NC_009483.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A5GCZ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5164574.
GenomeReviews	Gene locus Gura_0334 in contig CP000698_GR.
KEGG	gur:Gura_0334.
NMPDR	fig|351605.3.peg.1040.
PATRIC	22030504. VBIGeoUra13052_0348.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0838.
HOGENOM	HBG605540.
OMA	ALDWHKE.
ProtClustDB	CLSK829284.
Enzyme and pathway databases
BioCyc	GURA351605:GURA_0334-MONOMER.
Family and domain databases
HAMAP	MF_01394. NDH1_NuoA. [Tree]
InterPro	IPR023043. NAD(P)H_OxRDtase_bac/plastid. IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3. [Graphical view]
KO	K00330.
PANTHER	PTHR11058. Oxidored_q4. 1 hit.
Pfam	PF00507. Oxidored_q4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOA1_GEOUR

Accession

Primary (citable) accession number: A5GCZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 12, 2007
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program