A5GCY9 (A5GCY9_GEOUR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Ordered Locus Names:

Gura_0347

Organism

Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens) [Complete proteome] [HAMAP]

Taxonomic identifier

351605 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515 PIRSR PIRSR001415-3
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase RuleBase RU000515 EMBL ABQ24563.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	195	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	248	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	120	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	122	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	130	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	233	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	205	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	217	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	274	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	313	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	A5GCY9 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: EB17345331AC4353	FASTA	337	37,562
	10 20 30 40 50 60 MFFPQFRARR IRGKEVFRNM VRETSLSTND LIYPMFSAFG KGIRKEISSM PGIYQQSIEN 70 80 90 100 110 120 IVAEAQEAYE LGVPAVILFG IPEKKDAVGS DAYAEHGIIQ ETIRALKKDV PKLVVITDVC 130 140 150 160 170 180 MCEYTDHGHC GIIRNGDVDN DETLELLAKE ALSHARAGAD MVAPSDMMDG RVAAIRESLD 190 200 210 220 230 240 GNGFDHIPVM SYAVKYASGY YGPFREAAES TPQFGDRRSY QMDPANRLEA VREAQMDVEE 250 260 270 280 290 300 GADIIMVKPG LPYLDIVREM RNEFNLPVAV YNVSGEYSMI KAAGKMGWID EERVIMETMM 310 320 330 SFKRAGADLI LTYHAMEVAR LLHKGYEAGR AGRCGCP

References

[1]

"Complete sequence of Geobacter uraniireducens Rf4." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Shelobolina E., Aklujkar M., Lovley D., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rf4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000698 Genomic DNA. Translation: ABQ24563.1.
RefSeq	YP_001229136.1. NC_009483.1.
3D structure databases
ProteinModelPortal	A5GCY9.
SMR	A5GCY9. Positions 6-323.
ModBase	Search...
Protein-protein interaction databases
STRING	A5GCY9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5164787.
GenomeReviews	Gene locus Gura_0347 in contig CP000698_GR.
KEGG	gur:Gura_0347.
NMPDR	fig|351605.3.peg.1289.
PATRIC	22030536. VBIGeoUra13052_0363.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0113.
HOGENOM	HBG285270.
OMA	ADLCFCE.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5GCY9_GEOUR

Accession

Primary (citable) accession number: A5GCY9

Entry history

Integrated into UniProtKB/TrEMBL:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)