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A5GB52

- SPEA_GEOUR

UniProt

A5GB52 - SPEA_GEOUR

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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciGURA351605:GI6A-992-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:Gura_0983
OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Taxonomic identifieri351605 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000006695: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Biosynthetic arginine decarboxylasePRO_1000087404Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei100 – 1001N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi351605.Gura_0983.

Structurei

3D structure databases

ProteinModelPortaliA5GB52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni282 – 29211Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiARTMGLN.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5GB52-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERWSINDSA KIYNLNNWGA DLFSINKKGN VCVHPSSNSK HSIDLRALVD
60 70 80 90 100
DLIKRKIKPP ILLRFMDVLQ GRIASINRVF KNAIQENNYP AKYQTFYPIK
110 120 130 140 150
VNQQRQVVEA IANFGKRYNI GLEVGSKPEL VAGISFATGN NLPIICNGYK
160 170 180 190 200
DTEYIEMVLS ATKIGYDITL VVEKLFELEK IIELVKKTGV QPKLGIRVKL
210 220 230 240 250
SSKGIGKWAT SGGEDAKFGL RMSEIIAAIE MLEKHDLIKC VKLLHFHIGS
260 270 280 290 300
QITKIDKIKT ALIEGARIYA EMRKLGVGIE YLDIGGGLGV DYDGSKSSNF
310 320 330 340 350
SSVNYSIEEY ANDVIYQIKN ICEDAGVECP NIISESGRAT VAHYSVLVTN
360 370 380 390 400
VLNTNTQNIM PDFEATLNEA EKLAPTVKKL EDIYKSIDRY SLREDYHDTL
410 420 430 440 450
QLIQEAVSLF NLGYLTLNDR AMAEWLYGKI IRKINSIVEK IKPIPEELQN
460 470 480 490 500
FQLSLRQTYF ANFSLFQSVP DSWAIDQLFP IVPIQRLNQK PDVIASIADI
510 520 530 540 550
TCDSDGEITS FVGENGRTKF LPLHKIRKDE AYYIGFFLIG AYQEILGDMH
560 570 580 590 600
NLFGDTNAVH ITFNKKTGYI IDTVINGDAT WESLKYVQYK GPEILKRVRD
610 620 630
NLEKDVALRK ISIEESSHFL ELLDRTLLGY TYLGE
Length:635
Mass (Da):71,778
Last modified:June 12, 2007 - v1
Checksum:i7CE13746E2FB8758
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA. Translation: ABQ25189.1.
RefSeqiYP_001229762.1. NC_009483.1.

Genome annotation databases

EnsemblBacteriaiABQ25189; ABQ25189; Gura_0983.
GeneIDi5163174.
KEGGigur:Gura_0983.
PATRICi22031920. VBIGeoUra13052_1053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA. Translation: ABQ25189.1 .
RefSeqi YP_001229762.1. NC_009483.1.

3D structure databases

ProteinModelPortali A5GB52.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351605.Gura_0983.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ25189 ; ABQ25189 ; Gura_0983 .
GeneIDi 5163174.
KEGGi gur:Gura_0983.
PATRICi 22031920. VBIGeoUra13052_1053.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi ARTMGLN.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

UniPathwayi UPA00186 ; UER00284 .
BioCyci GURA351605:GI6A-992-MONOMER.

Family and domain databases

Gene3Di 3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rf4.

Entry informationi

Entry nameiSPEA_GEOUR
AccessioniPrimary (citable) accession number: A5GB52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3