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A5GB52

- SPEA_GEOUR

UniProt

A5GB52 - SPEA_GEOUR

Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

    Catalytic activityi

    L-arginine = agmatine + CO2.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation
    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine catabolic process Source: InterPro
    2. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Polyamine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciGURA351605:GI6A-992-MONOMER.
    UniPathwayiUPA00186; UER00284.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
    Short name:
    ADCUniRule annotation
    Gene namesi
    Name:speAUniRule annotation
    Ordered Locus Names:Gura_0983
    OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
    Taxonomic identifieri351605 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000006695: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 635635Biosynthetic arginine decarboxylasePRO_1000087404Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei100 – 1001N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi351605.Gura_0983.

    Structurei

    3D structure databases

    ProteinModelPortaliA5GB52.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni282 – 29211Substrate-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1166.
    HOGENOMiHOG000029191.
    KOiK01585.
    OMAiARTMGLN.
    OrthoDBiEOG676Z0R.

    Family and domain databases

    Gene3Di3.20.20.10. 1 hit.
    HAMAPiMF_01417. SpeA.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSiPR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR01273. speA. 1 hit.
    PROSITEiPS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5GB52-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERWSINDSA KIYNLNNWGA DLFSINKKGN VCVHPSSNSK HSIDLRALVD    50
    DLIKRKIKPP ILLRFMDVLQ GRIASINRVF KNAIQENNYP AKYQTFYPIK 100
    VNQQRQVVEA IANFGKRYNI GLEVGSKPEL VAGISFATGN NLPIICNGYK 150
    DTEYIEMVLS ATKIGYDITL VVEKLFELEK IIELVKKTGV QPKLGIRVKL 200
    SSKGIGKWAT SGGEDAKFGL RMSEIIAAIE MLEKHDLIKC VKLLHFHIGS 250
    QITKIDKIKT ALIEGARIYA EMRKLGVGIE YLDIGGGLGV DYDGSKSSNF 300
    SSVNYSIEEY ANDVIYQIKN ICEDAGVECP NIISESGRAT VAHYSVLVTN 350
    VLNTNTQNIM PDFEATLNEA EKLAPTVKKL EDIYKSIDRY SLREDYHDTL 400
    QLIQEAVSLF NLGYLTLNDR AMAEWLYGKI IRKINSIVEK IKPIPEELQN 450
    FQLSLRQTYF ANFSLFQSVP DSWAIDQLFP IVPIQRLNQK PDVIASIADI 500
    TCDSDGEITS FVGENGRTKF LPLHKIRKDE AYYIGFFLIG AYQEILGDMH 550
    NLFGDTNAVH ITFNKKTGYI IDTVINGDAT WESLKYVQYK GPEILKRVRD 600
    NLEKDVALRK ISIEESSHFL ELLDRTLLGY TYLGE 635
    Length:635
    Mass (Da):71,778
    Last modified:June 12, 2007 - v1
    Checksum:i7CE13746E2FB8758
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000698 Genomic DNA. Translation: ABQ25189.1.
    RefSeqiYP_001229762.1. NC_009483.1.

    Genome annotation databases

    EnsemblBacteriaiABQ25189; ABQ25189; Gura_0983.
    GeneIDi5163174.
    KEGGigur:Gura_0983.
    PATRICi22031920. VBIGeoUra13052_1053.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000698 Genomic DNA. Translation: ABQ25189.1 .
    RefSeqi YP_001229762.1. NC_009483.1.

    3D structure databases

    ProteinModelPortali A5GB52.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351605.Gura_0983.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ25189 ; ABQ25189 ; Gura_0983 .
    GeneIDi 5163174.
    KEGGi gur:Gura_0983.
    PATRICi 22031920. VBIGeoUra13052_1053.

    Phylogenomic databases

    eggNOGi COG1166.
    HOGENOMi HOG000029191.
    KOi K01585.
    OMAi ARTMGLN.
    OrthoDBi EOG676Z0R.

    Enzyme and pathway databases

    UniPathwayi UPA00186 ; UER00284 .
    BioCyci GURA351605:GI6A-992-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.10. 1 hit.
    HAMAPi MF_01417. SpeA.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSi PR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR01273. speA. 1 hit.
    PROSITEi PS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rf4.

    Entry informationi

    Entry nameiSPEA_GEOUR
    AccessioniPrimary (citable) accession number: A5GB52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3