A5GAY8 (ARGC_GEOUR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Gura_1051

Organism

Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens) [Complete proteome] [HAMAP]

Taxonomic identifier

351605 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm By similarity HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000076733
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5GAY8 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 44A5CBD26F4E3199	FASTA	346	37,492
	10 20 30 40 50 60 MLKVAIVGAS GYTGVELLRL LHCHPEVAIT CVTSEQSAGK AISEVFPTLR SRYNLVLENL 70 80 90 100 110 120 EPVRIADRAD FIFTALPHKA AMEVVPTFLK LGKRVVDLSA DYRLRDAKEY EAWYEPHMNP 130 140 150 160 170 180 TLLEQSVYGL PELRREKIAG ADLVANPGCY PTSVILGLAP LLKKKLIDPA TIIADSKSGV 190 200 210 220 230 240 SGAGRSAKVD NLYCEVNDGF KAYGVGGAHR HIPEIEQELS LLAGKQLKIS FTPHLVPMDR 250 260 270 280 290 300 GILSTIYATP TGAVSSAELL ELYRAYYQGE AFVRILPEGS FPSTSHVRGS NFCDIGLAVD 310 320 330 340 NRTGRVVVVS AIDNLIKGAS GQAVQNMNIM NGFPENLGLE ALALFP

References

[1]

"Complete sequence of Geobacter uraniireducens Rf4." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Shelobolina E., Aklujkar M., Lovley D., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rf4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000698 Genomic DNA. Translation: ABQ25257.1.
RefSeq	YP_001229830.1. NC_009483.1.
3D structure databases
ProteinModelPortal	A5GAY8.
ModBase	Search...
Protein-protein interaction databases
STRING	A5GAY8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5165881.
GenomeReviews	Gene locus Gura_1051 in contig CP000698_GR.
KEGG	gur:Gura_1051.
NMPDR	fig|351605.3.peg.2264.
PATRIC	22032066. VBIGeoUra13052_1126.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	TAEDCTT.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	GURA351605:GURA_1051-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_GEOUR

Accession

Primary (citable) accession number: A5GAY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	June 12, 2007
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program