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A5G9I9 (A5G9I9_GEOUR) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lipoprotein signal peptidase RuleBase RU000594 HAMAP-Rule MF_00161

EC=3.4.23.36 RuleBase RU000594 HAMAP-Rule MF_00161
Alternative name(s):
Prolipoprotein signal peptidase HAMAP-Rule MF_00161
Signal peptidase II HAMAP-Rule MF_00161
Gene names
Name:lspA HAMAP-Rule MF_00161
Ordered Locus Names:Gura_4314 EMBL ABQ28457.1
OrganismGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens) [Complete proteome] [HAMAP] EMBL ABQ28457.1
Taxonomic identifier351605 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity. RuleBase RU000594 HAMAP-Rule MF_00161

Catalytic activity

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. RuleBase RU000594 HAMAP-Rule MF_00161 SAAS SAAS001872

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage). HAMAP-Rule MF_00161 SAAS SAAS001872

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00161.

Sequence similarities

Belongs to the peptidase A8 family. HAMAP-Rule MF_00161

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Transmembrane6 – 2621Helical; By similarity HAMAP-Rule MF_00161
Transmembrane65 – 8521Helical; By similarity HAMAP-Rule MF_00161
Transmembrane92 – 11221Helical; By similarity HAMAP-Rule MF_00161
Transmembrane133 – 15321Helical; By similarity HAMAP-Rule MF_00161

Sites

Active site1101 By similarity HAMAP-Rule MF_00161
Active site1371 By similarity HAMAP-Rule MF_00161

Sequences

Sequence LengthMass (Da)Tools
A5G9I9 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: B7F123E40F3EB4E3

FASTA16318,583
        10         20         30         40         50         60 
MKLKYLILLT VSILVIGIDQ ATKLFVNKVM DLHSSITVVQ NFFNITYMRN KGAAFSFLSN 

        70         80         90        100        110        120 
FNYRIPFFIL VSLVAVVVII SVIYKLRPDQ KFAALSLSLI LSGALGNLID RVRLGEVIDF 

       130        140        150        160 
LDAHWYEHHW PAFNVADSAI CVGVFLLAID MFLEEQRQKK QKD 

« Hide

References

[1]"Complete sequence of Geobacter uraniireducens Rf4."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Shelobolina E., Aklujkar M., Lovley D., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rf4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000698 Genomic DNA. Translation: ABQ28457.1.
RefSeqYP_001233030.1. NC_009483.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING351605.Gura_4314.

Protein family/group databases

MEROPSA08.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ28457; ABQ28457; Gura_4314.
GeneID5163373.
KEGGgur:Gura_4314.
PATRIC22039094. VBIGeoUra13052_4592.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0597.
HOGENOMHOG000096992.
KOK03101.
OMAAWNILTG.
OrthoDBEOG6PGKBM.
ProtClustDBPRK00376.

Enzyme and pathway databases

BioCycGURA351605:GI6A-4370-MONOMER.
UniPathwayUPA00665.

Family and domain databases

HAMAPMF_00161. LspA.
InterProIPR001872. Peptidase_A8.
[Graphical view]
PfamPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSPR00781. LIPOSIGPTASE.
TIGRFAMsTIGR00077. lspA. 1 hit.
PROSITEPS00855. SPASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5G9I9_GEOUR
AccessionPrimary (citable) accession number: A5G9I9
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)