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A5G9I9

- A5G9I9_GEOUR

UniProt

A5G9I9 - A5G9I9_GEOUR

Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    This protein specifically catalyzes the removal of signal peptides from prolipoproteins.UniRule annotationSAAS annotation

    Catalytic activityi

    Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei110 – 1101UniRule annotation
    Active sitei137 – 1371UniRule annotation

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aspartyl proteaseUniRule annotationSAAS annotation, Hydrolase, Protease

    Enzyme and pathway databases

    BioCyciGURA351605:GI6A-4370-MONOMER.
    UniPathwayiUPA00665.

    Protein family/group databases

    MEROPSiA08.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipoprotein signal peptidaseUniRule annotation (EC:3.4.23.36UniRule annotation)
    Alternative name(s):
    Prolipoprotein signal peptidaseUniRule annotation
    Signal peptidase IIUniRule annotation
    Gene namesi
    Name:lspAUniRule annotation
    Ordered Locus Names:Gura_4314Imported
    OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)Imported
    Taxonomic identifieri351605 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000006695: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membraneUniRule annotation, Cell membrane, Membrane

    Interactioni

    Protein-protein interaction databases

    STRINGi351605.Gura_4314.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621Helical;UniRule annotationAdd
    BLAST
    Transmembranei65 – 8521Helical;UniRule annotationAdd
    BLAST
    Transmembranei92 – 11221Helical;UniRule annotationAdd
    BLAST
    Transmembranei133 – 15321Helical;UniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase A8 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0597.
    HOGENOMiHOG000096992.
    KOiK03101.
    OMAiDCAITVG.
    OrthoDBiEOG6PGKBM.

    Family and domain databases

    HAMAPiMF_00161. LspA.
    InterProiIPR001872. Peptidase_A8.
    [Graphical view]
    PfamiPF01252. Peptidase_A8. 1 hit.
    [Graphical view]
    PRINTSiPR00781. LIPOSIGPTASE.
    TIGRFAMsiTIGR00077. lspA. 1 hit.
    PROSITEiPS00855. SPASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5G9I9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLKYLILLT VSILVIGIDQ ATKLFVNKVM DLHSSITVVQ NFFNITYMRN    50
    KGAAFSFLSN FNYRIPFFIL VSLVAVVVII SVIYKLRPDQ KFAALSLSLI 100
    LSGALGNLID RVRLGEVIDF LDAHWYEHHW PAFNVADSAI CVGVFLLAID 150
    MFLEEQRQKK QKD 163
    Length:163
    Mass (Da):18,583
    Last modified:June 12, 2007 - v1
    Checksum:iB7F123E40F3EB4E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000698 Genomic DNA. Translation: ABQ28457.1.
    RefSeqiWP_011941087.1. NC_009483.1.
    YP_001233030.1. NC_009483.1.

    Genome annotation databases

    EnsemblBacteriaiABQ28457; ABQ28457; Gura_4314.
    GeneIDi5163373.
    KEGGigur:Gura_4314.
    PATRICi22039094. VBIGeoUra13052_4592.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000698 Genomic DNA. Translation: ABQ28457.1 .
    RefSeqi WP_011941087.1. NC_009483.1.
    YP_001233030.1. NC_009483.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351605.Gura_4314.

    Protein family/group databases

    MEROPSi A08.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ28457 ; ABQ28457 ; Gura_4314 .
    GeneIDi 5163373.
    KEGGi gur:Gura_4314.
    PATRICi 22039094. VBIGeoUra13052_4592.

    Phylogenomic databases

    eggNOGi COG0597.
    HOGENOMi HOG000096992.
    KOi K03101.
    OMAi DCAITVG.
    OrthoDBi EOG6PGKBM.

    Enzyme and pathway databases

    UniPathwayi UPA00665 .
    BioCyci GURA351605:GI6A-4370-MONOMER.

    Family and domain databases

    HAMAPi MF_00161. LspA.
    InterProi IPR001872. Peptidase_A8.
    [Graphical view ]
    Pfami PF01252. Peptidase_A8. 1 hit.
    [Graphical view ]
    PRINTSi PR00781. LIPOSIGPTASE.
    TIGRFAMsi TIGR00077. lspA. 1 hit.
    PROSITEi PS00855. SPASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rf4Imported.

    Entry informationi

    Entry nameiA5G9I9_GEOUR
    AccessioniPrimary (citable) accession number: A5G9I9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 12, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3