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A5G9I9

- A5G9I9_GEOUR

UniProt

A5G9I9 - A5G9I9_GEOUR

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Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.UniRule annotationSAAS annotation

Catalytic activityi

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei110 – 1101UniRule annotation
Active sitei137 – 1371UniRule annotation

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl proteaseUniRule annotation, Hydrolase, Protease

Enzyme and pathway databases

BioCyciGURA351605:GI6A-4370-MONOMER.
UniPathwayiUPA00665.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein signal peptidaseUniRule annotation (EC:3.4.23.36UniRule annotation)
Alternative name(s):
Prolipoprotein signal peptidaseUniRule annotation
Signal peptidase IIUniRule annotation
Gene namesi
Name:lspAUniRule annotation
Ordered Locus Names:Gura_4314Imported
OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)Imported
Taxonomic identifieri351605 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000006695: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Protein-protein interaction databases

STRINGi351605.Gura_4314.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalUniRule annotationAdd
BLAST
Transmembranei65 – 8521HelicalUniRule annotationAdd
BLAST
Transmembranei92 – 11221HelicalUniRule annotationAdd
BLAST
Transmembranei133 – 15321HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A8 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiCOG0597.
HOGENOMiHOG000096992.
KOiK03101.
OMAiDCAITVG.
OrthoDBiEOG6PGKBM.

Family and domain databases

HAMAPiMF_00161. LspA.
InterProiIPR001872. Peptidase_A8.
[Graphical view]
PfamiPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSiPR00781. LIPOSIGPTASE.
TIGRFAMsiTIGR00077. lspA. 1 hit.
PROSITEiPS00855. SPASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5G9I9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLKYLILLT VSILVIGIDQ ATKLFVNKVM DLHSSITVVQ NFFNITYMRN
60 70 80 90 100
KGAAFSFLSN FNYRIPFFIL VSLVAVVVII SVIYKLRPDQ KFAALSLSLI
110 120 130 140 150
LSGALGNLID RVRLGEVIDF LDAHWYEHHW PAFNVADSAI CVGVFLLAID
160
MFLEEQRQKK QKD
Length:163
Mass (Da):18,583
Last modified:June 12, 2007 - v1
Checksum:iB7F123E40F3EB4E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000698 Genomic DNA. Translation: ABQ28457.1.
RefSeqiWP_011941087.1. NC_009483.1.
YP_001233030.1. NC_009483.1.

Genome annotation databases

EnsemblBacteriaiABQ28457; ABQ28457; Gura_4314.
GeneIDi5163373.
KEGGigur:Gura_4314.
PATRICi22039094. VBIGeoUra13052_4592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000698 Genomic DNA. Translation: ABQ28457.1 .
RefSeqi WP_011941087.1. NC_009483.1.
YP_001233030.1. NC_009483.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351605.Gura_4314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ28457 ; ABQ28457 ; Gura_4314 .
GeneIDi 5163373.
KEGGi gur:Gura_4314.
PATRICi 22039094. VBIGeoUra13052_4592.

Phylogenomic databases

eggNOGi COG0597.
HOGENOMi HOG000096992.
KOi K03101.
OMAi DCAITVG.
OrthoDBi EOG6PGKBM.

Enzyme and pathway databases

UniPathwayi UPA00665 .
BioCyci GURA351605:GI6A-4370-MONOMER.

Family and domain databases

HAMAPi MF_00161. LspA.
InterProi IPR001872. Peptidase_A8.
[Graphical view ]
Pfami PF01252. Peptidase_A8. 1 hit.
[Graphical view ]
PRINTSi PR00781. LIPOSIGPTASE.
TIGRFAMsi TIGR00077. lspA. 1 hit.
PROSITEi PS00855. SPASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rf4Imported.

Entry informationi

Entry nameiA5G9I9_GEOUR
AccessioniPrimary (citable) accession number: A5G9I9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3