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A5G8S1

- GCH4_GEOUR

UniProt

A5G8S1 - GCH4_GEOUR

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, Gura_4045
Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei144 – 1441May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciGURA351605:GI6A-4100-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Gura_4045
OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Taxonomic identifieri351605 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000006695: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271GTP cyclohydrolase FolE2UniRule annotation
PRO_0000372030Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351605.Gura_4045.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

A5G8S1-1 [UniParc]FASTAAdd to Basket

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MSDVQKSRDT RNIPISKVGV KDISYPIVIM DKNKSIQHTV ARINMYVDLP    50
HHFKGTHMSR FIEILNVYRE KIALDNMEAM LQRMKEKLGA GSAHVEIEFP 100
YFIEKKAPAS GAKSLMEYTC EFSASLSSEF DFILGIKVPV TSLCPCSKEL 150
SHYGAHNQRS IMTVRVRYRE FVWIEDLIEI VEGCGSSPVY SLLKREDEKF 200
VTEKAYENPK FVEDMVREAT QKLLAMEKIT WFSVEAENFE SIHNHSAYAA 250
IERDKREKGV DNPVDKPGNC G 271
Length:271
Mass (Da):31,024
Last modified:May 5, 2009 - v2
Checksum:iE795508578440CB3
GO

Sequence cautioni

The sequence ABQ28189.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000698 Genomic DNA. Translation: ABQ28189.1. Different initiation.
RefSeqiYP_001232762.1. NC_009483.1.

Genome annotation databases

EnsemblBacteriaiABQ28189; ABQ28189; Gura_4045.
GeneIDi5166195.
KEGGigur:Gura_4045.
PATRICi22038535. VBIGeoUra13052_4314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000698 Genomic DNA. Translation: ABQ28189.1 . Different initiation.
RefSeqi YP_001232762.1. NC_009483.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351605.Gura_4045.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ28189 ; ABQ28189 ; Gura_4045 .
GeneIDi 5166195.
KEGGi gur:Gura_4045.
PATRICi 22038535. VBIGeoUra13052_4314.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci GURA351605:GI6A-4100-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rf4.

Entry informationi

Entry nameiGCH4_GEOUR
AccessioniPrimary (citable) accession number: A5G8S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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