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Protein

Alanine racemase

Gene

Gura_3850

Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei143 – 1431SubstrateUniRule annotation
Active sitei275 – 2751Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei323 – 3231Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciGURA351605:GI6A-3902-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Gura_3850Imported
OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)Imported
Taxonomic identifieri351605 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000006695: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi351605.Gura_3850.

Structurei

3D structure databases

ProteinModelPortaliA5G882.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5G882-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERLNVLNLD SRPTIAEIDL AALRHNYYQV KKAVPAGSGL LAVVKADAYG
60 70 80 90 100
HGFMDISREL EALGVTAFGV AFLAEGIQLR KSGIDRPILL LGGIYPGQEK
110 120 130 140 150
KCVGFNISTA VFSLDQARVL DDVARKLYRK AKIHLKVDTG MGRLGIRYEE
160 170 180 190 200
APAFFRELKK LKNLELEGIF SHFASADELD DEGSGYTARQ TEIFAAVLQE
210 220 230 240 250
GTRQGFSPTF VHIANSAAAF SRDFPFCNLA RPGIVLYGAL PSADFQGKID
260 270 280 290 300
VKPVMRLKSR VAMLKWVEPG TSISYARRYV AGKKTLVASV PVGYADGYCR
310 320 330 340 350
ALTNKGEALV RGQRARVAGT VCMDWIMLDV TDIAGVAVGD EVTLLGCDNQ
360 370 380
GNCIHAEELA AWSGTIAYEI FCGISKRVPR VYIP
Length:384
Mass (Da):41,874
Last modified:June 12, 2007 - v1
Checksum:iB86560FE305BFBD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA. Translation: ABQ28000.1.
RefSeqiYP_001232573.1. NC_009483.1.

Genome annotation databases

EnsemblBacteriaiABQ28000; ABQ28000; Gura_3850.
GeneIDi5166061.
KEGGigur:Gura_3850.
PATRICi22038119. VBIGeoUra13052_4108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA. Translation: ABQ28000.1.
RefSeqiYP_001232573.1. NC_009483.1.

3D structure databases

ProteinModelPortaliA5G882.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351605.Gura_3850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ28000; ABQ28000; Gura_3850.
GeneIDi5166061.
KEGGigur:Gura_3850.
PATRICi22038119. VBIGeoUra13052_4108.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciGURA351605:GI6A-3902-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rf4Imported.

Entry informationi

Entry nameiA5G882_GEOUR
AccessioniPrimary (citable) accession number: A5G882
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: February 4, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.