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A5G879

- PUR9_GEOUR

UniProt

A5G879 - PUR9_GEOUR

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciGURA351605:GI6A-3899-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Gura_3847
OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Taxonomic identifieri351605 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000006695: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Bifunctional purine biosynthesis protein PurHPRO_1000076482Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351605.Gura_3847.

Structurei

3D structure databases

ProteinModelPortaliA5G879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A5G879-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKITRALIS VSDKTGIVEF SRELAGYGVE ILSTGGTAKL LREAGLKVKD
60 70 80 90 100
VSEFTGFPEM LDGRVKTLHP KVHGGLLGMR GNPEHVATMK AHGIEPIDMV
110 120 130 140 150
VVNLYPFEAT VAKPDCTLED AIENIDIGGP TMLRSAAKNN ADVTVVVDHN
160 170 180 190 200
DYRLVLDEMK AAGGGVSKET NFRLAVKVYQ HTAAYDGAIS NWLGARTGEG
210 220 230 240 250
VAAYPDTLTL QFKKAQGMRY GENPHQSAAF YVERDVKEAS VATARQLQGK
260 270 280 290 300
ELSYNNIGDT DAALECVKQF AEGPGCVIVK HANPCGVAIG DTLLDAYDRA
310 320 330 340 350
YKTDPESAFG GIIAFNGELD EATAKAIVER QFVEVIIAPK VSAKASEVVA
360 370 380 390 400
AKKNVRLLEC GTWQKEPMPR LDFKRVNGGL LVQYTDLALH GELKVVTKRA
410 420 430 440 450
PTEKEMIDLL FTWRVAKFVK SNAIVYGKDG MTIGVGAGQM SRVNSARIAA
460 470 480 490 500
IKAEHAGLPV AGSVMASDAF FPFRDGLDNA AAVGITAVIQ PGGSMRDEEV
510 520
IAAADEHGMA MVFTSMRHFR H
Length:521
Mass (Da):56,027
Last modified:June 12, 2007 - v1
Checksum:i70476ADFD8902271
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA. Translation: ABQ27997.1.
RefSeqiWP_011940643.1. NC_009483.1.
YP_001232570.1. NC_009483.1.

Genome annotation databases

EnsemblBacteriaiABQ27997; ABQ27997; Gura_3847.
GeneIDi5166435.
KEGGigur:Gura_3847.
PATRICi22038113. VBIGeoUra13052_4105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA. Translation: ABQ27997.1 .
RefSeqi WP_011940643.1. NC_009483.1.
YP_001232570.1. NC_009483.1.

3D structure databases

ProteinModelPortali A5G879.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351605.Gura_3847.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ27997 ; ABQ27997 ; Gura_3847 .
GeneIDi 5166435.
KEGGi gur:Gura_3847.
PATRICi 22038113. VBIGeoUra13052_4105.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci GURA351605:GI6A-3899-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rf4.

Entry informationi

Entry nameiPUR9_GEOUR
AccessioniPrimary (citable) accession number: A5G879
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: November 26, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3