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A5G879

- PUR9_GEOUR

UniProt

A5G879 - PUR9_GEOUR

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Gura_3847
Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciGURA351605:GI6A-3899-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Gura_3847
OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Taxonomic identifieri351605 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000006695: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000076482Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351605.Gura_3847.

Structurei

3D structure databases

ProteinModelPortaliA5G879.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A5G879-1 [UniParc]FASTAAdd to Basket

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MAKITRALIS VSDKTGIVEF SRELAGYGVE ILSTGGTAKL LREAGLKVKD    50
VSEFTGFPEM LDGRVKTLHP KVHGGLLGMR GNPEHVATMK AHGIEPIDMV 100
VVNLYPFEAT VAKPDCTLED AIENIDIGGP TMLRSAAKNN ADVTVVVDHN 150
DYRLVLDEMK AAGGGVSKET NFRLAVKVYQ HTAAYDGAIS NWLGARTGEG 200
VAAYPDTLTL QFKKAQGMRY GENPHQSAAF YVERDVKEAS VATARQLQGK 250
ELSYNNIGDT DAALECVKQF AEGPGCVIVK HANPCGVAIG DTLLDAYDRA 300
YKTDPESAFG GIIAFNGELD EATAKAIVER QFVEVIIAPK VSAKASEVVA 350
AKKNVRLLEC GTWQKEPMPR LDFKRVNGGL LVQYTDLALH GELKVVTKRA 400
PTEKEMIDLL FTWRVAKFVK SNAIVYGKDG MTIGVGAGQM SRVNSARIAA 450
IKAEHAGLPV AGSVMASDAF FPFRDGLDNA AAVGITAVIQ PGGSMRDEEV 500
IAAADEHGMA MVFTSMRHFR H 521
Length:521
Mass (Da):56,027
Last modified:June 12, 2007 - v1
Checksum:i70476ADFD8902271
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000698 Genomic DNA. Translation: ABQ27997.1.
RefSeqiWP_011940643.1. NC_009483.1.
YP_001232570.1. NC_009483.1.

Genome annotation databases

EnsemblBacteriaiABQ27997; ABQ27997; Gura_3847.
GeneIDi5166435.
KEGGigur:Gura_3847.
PATRICi22038113. VBIGeoUra13052_4105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000698 Genomic DNA. Translation: ABQ27997.1 .
RefSeqi WP_011940643.1. NC_009483.1.
YP_001232570.1. NC_009483.1.

3D structure databases

ProteinModelPortali A5G879.
ModBasei Search...

Protein-protein interaction databases

STRINGi 351605.Gura_3847.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ27997 ; ABQ27997 ; Gura_3847 .
GeneIDi 5166435.
KEGGi gur:Gura_3847.
PATRICi 22038113. VBIGeoUra13052_4105.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci GURA351605:GI6A-3899-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rf4.

Entry informationi

Entry nameiPUR9_GEOUR
AccessioniPrimary (citable) accession number: A5G879
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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