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Protein

Protein-L-isoaspartate O-methyltransferase 3

Gene

pcm3

Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciGURA351605:GI6A-3379-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferase 3UniRule annotation (EC:2.1.1.77UniRule annotation)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferase 3UniRule annotation
Protein L-isoaspartyl methyltransferase 3UniRule annotation
Protein-beta-aspartate methyltransferase 3UniRule annotation
Short name:
PIMT 3UniRule annotation
Gene namesi
Name:pcm3UniRule annotation
Ordered Locus Names:Gura_3331
OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Taxonomic identifieri351605 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000006695 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Protein-L-isoaspartate O-methyltransferase 3PRO_0000351864Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351605.Gura_3331.

Structurei

3D structure databases

ProteinModelPortaliA5G6S0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E26. Bacteria.
COG2518. LUCA.
HOGENOMiHOG000257189.
KOiK00573.
OMAiGDGYHGW.
OrthoDBiEOG644ZP2.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.

Sequencei

Sequence statusi: Complete.

A5G6S0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVIILAFAL LLTTASVLSS ATDPYLQKRQ EMVRDDIRGR GIKDGRVLDA
60 70 80 90 100
MAKIPRHLFV GERLRRQAYA DTPLPIGEGQ TISQPYVVAL MTEALRLKPG
110 120 130 140 150
DRVLEIGTGS GYQAAVLAEM VKDVYSIEIR KDLAETADKR LKELGYKNVA
160 170 180 190 200
VKYGDGYLGW PEYAPFDAVI ITASVNHIPP PLLKQLKEGG RLILPLGSTL
210 220 230
FYQTLTLVTK KKGGDLAVEQ MGAVAFVPMT GEAQKR
Length:236
Mass (Da):25,955
Last modified:June 12, 2007 - v1
Checksum:i9DA5B93832AC8A22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA. Translation: ABQ27488.1.
RefSeqiWP_011940149.1. NC_009483.1.

Genome annotation databases

EnsemblBacteriaiABQ27488; ABQ27488; Gura_3331.
KEGGigur:Gura_3331.
PATRICi22037007. VBIGeoUra13052_3556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA. Translation: ABQ27488.1.
RefSeqiWP_011940149.1. NC_009483.1.

3D structure databases

ProteinModelPortaliA5G6S0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351605.Gura_3331.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ27488; ABQ27488; Gura_3331.
KEGGigur:Gura_3331.
PATRICi22037007. VBIGeoUra13052_3556.

Phylogenomic databases

eggNOGiENOG4105E26. Bacteria.
COG2518. LUCA.
HOGENOMiHOG000257189.
KOiK00573.
OMAiGDGYHGW.
OrthoDBiEOG644ZP2.

Enzyme and pathway databases

BioCyciGURA351605:GI6A-3379-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rf4.

Entry informationi

Entry nameiPIMT3_GEOUR
AccessioniPrimary (citable) accession number: A5G6S0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: June 12, 2007
Last modified: May 11, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.