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Protein

Protein-L-isoaspartate O-methyltransferase 3

Gene

pcm3

Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciGURA351605:G1G8X-3466-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferase 3UniRule annotation (EC:2.1.1.77UniRule annotation)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferase 3UniRule annotation
Protein L-isoaspartyl methyltransferase 3UniRule annotation
Protein-beta-aspartate methyltransferase 3UniRule annotation
Short name:
PIMT 3UniRule annotation
Gene namesi
Name:pcm3UniRule annotation
Ordered Locus Names:Gura_3331
OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Taxonomic identifieri351605 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000006695 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003518641 – 236Protein-L-isoaspartate O-methyltransferase 3Add BLAST236

Interactioni

Protein-protein interaction databases

STRINGi351605.Gura_3331

Structurei

3D structure databases

ProteinModelPortaliA5G6S0
SMRiA5G6S0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E26 Bacteria
COG2518 LUCA
HOGENOMiHOG000257189
KOiK00573
OMAiYSSRTIP
OrthoDBiPOG091H06AY

Family and domain databases

HAMAPiMF_00090 PIMT, 1 hit
InterProiView protein in InterPro
IPR000682 PCMT
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11579 PTHR11579, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00080 pimt, 1 hit

Sequencei

Sequence statusi: Complete.

A5G6S0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVIILAFAL LLTTASVLSS ATDPYLQKRQ EMVRDDIRGR GIKDGRVLDA
60 70 80 90 100
MAKIPRHLFV GERLRRQAYA DTPLPIGEGQ TISQPYVVAL MTEALRLKPG
110 120 130 140 150
DRVLEIGTGS GYQAAVLAEM VKDVYSIEIR KDLAETADKR LKELGYKNVA
160 170 180 190 200
VKYGDGYLGW PEYAPFDAVI ITASVNHIPP PLLKQLKEGG RLILPLGSTL
210 220 230
FYQTLTLVTK KKGGDLAVEQ MGAVAFVPMT GEAQKR
Length:236
Mass (Da):25,955
Last modified:June 12, 2007 - v1
Checksum:i9DA5B93832AC8A22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA Translation: ABQ27488.1
RefSeqiWP_011940149.1, NC_009483.1

Genome annotation databases

EnsemblBacteriaiABQ27488; ABQ27488; Gura_3331
KEGGigur:Gura_3331

Similar proteinsi

Entry informationi

Entry nameiPIMT3_GEOUR
AccessioniPrimary (citable) accession number: A5G6S0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: June 12, 2007
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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