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A5G677

- SYL_GEOUR

UniProt

A5G677 - SYL_GEOUR

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Protein
Leucine--tRNA ligase
Gene
leuS, Gura_3134
Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGURA351605:GI6A-3178-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Gura_3134
OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Taxonomic identifieri351605 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000006695: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 824824Leucine--tRNA ligaseUniRule annotation
PRO_1000074835Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351605.Gura_3134.

Structurei

3D structure databases

ProteinModelPortaliA5G677.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi581 – 5855"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5G677-1 [UniParc]FASTAAdd to Basket

« Hide

MEEKYLPSRV EEKWQKFWEA NKSFRATEDK TREKYYLLEM FPYPSGRIHM    50
GHVRNYSIGD VIARFKRMKG FNVLHPMGWD AFGMPAENAA IQNKSHPAKW 100
TYENIAYMRG QLKKMGLSYD WDRELATCDV DYYKWEQLIF LQMYKKGLAY 150
KKISSVNWCP KCETVLANEQ VEDGCCWRCD SNVDQKELEQ WSFRITDYAE 200
ELLEYTYKLP GWPERVLTMQ RNWIGRSTGC EIDFPIEGQM DKIKVFTTRQ 250
DTLFGATFMS LAPEHPMALE LTTPENMATV AAFIEKVKKT DRIRRTAEDF 300
EKEGVFTGSY CINPVTNRRM PVYLANFVLT DYGTGAVMAV PTHDQRDFEF 350
ARKYDIPMGV VIQPEGEALD PQTMAEAFTA EGIMVNSGRF DGLKSGAAKE 400
QIADYLEKEG IGKKTVNYRL RDWGISRQRY WGNPIPMIYC DLCGAVPVPE 450
TDLPVVLPMD ATFTGEGGNP LDKVDSFVNT TCPQCGEAAR RETDTMDTFV 500
ESSWYFLRYC CPDFVSGPLD KEKTEYWMSV DQYIGGIEHA VMHLLYARFF 550
TKVLRDLGYC DIDEPFTNLL TQGMVIKDGA KMSKSKGNVV DPNALIDKYG 600
ADTARLFSLF AAPPEKDLDW SDQGVDGSFR FLNRVWKLVY DTLPIIGGAG 650
ALDPAGLTNE GKGLRRQVHK TIRKVTEDIE ERFHFNTAIA ATMELVNTIQ 700
SFEPKNSPQN APVLKEAIES VVMLLAPFVP HFTEELWAQL GNNKSLEQAG 750
WPAFDSAAAI DEELLVVVQV NGKLRGKLTV AVTASEDDVK GAALADERVK 800
PFIEGKSVKK IVYVPGKLVN IVVG 824
Length:824
Mass (Da):93,456
Last modified:June 12, 2007 - v1
Checksum:i5AA28FA742CB2ABA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000698 Genomic DNA. Translation: ABQ27295.1.
RefSeqiYP_001231868.1. NC_009483.1.

Genome annotation databases

EnsemblBacteriaiABQ27295; ABQ27295; Gura_3134.
GeneIDi5164939.
KEGGigur:Gura_3134.
PATRICi22036589. VBIGeoUra13052_3352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000698 Genomic DNA. Translation: ABQ27295.1 .
RefSeqi YP_001231868.1. NC_009483.1.

3D structure databases

ProteinModelPortali A5G677.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351605.Gura_3134.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ27295 ; ABQ27295 ; Gura_3134 .
GeneIDi 5164939.
KEGGi gur:Gura_3134.
PATRICi 22036589. VBIGeoUra13052_3352.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci GURA351605:GI6A-3178-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rf4.

Entry informationi

Entry nameiSYL_GEOUR
AccessioniPrimary (citable) accession number: A5G677
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi