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A5G677

- SYL_GEOUR

UniProt

A5G677 - SYL_GEOUR

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei584 – 5841ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGURA351605:GI6A-3178-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Gura_3134
    OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
    Taxonomic identifieri351605 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000006695: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 824824Leucine--tRNA ligasePRO_1000074835Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351605.Gura_3134.

    Structurei

    3D structure databases

    ProteinModelPortaliA5G677.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi581 – 5855"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHELEVYT.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5G677-1 [UniParc]FASTAAdd to Basket

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    MEEKYLPSRV EEKWQKFWEA NKSFRATEDK TREKYYLLEM FPYPSGRIHM    50
    GHVRNYSIGD VIARFKRMKG FNVLHPMGWD AFGMPAENAA IQNKSHPAKW 100
    TYENIAYMRG QLKKMGLSYD WDRELATCDV DYYKWEQLIF LQMYKKGLAY 150
    KKISSVNWCP KCETVLANEQ VEDGCCWRCD SNVDQKELEQ WSFRITDYAE 200
    ELLEYTYKLP GWPERVLTMQ RNWIGRSTGC EIDFPIEGQM DKIKVFTTRQ 250
    DTLFGATFMS LAPEHPMALE LTTPENMATV AAFIEKVKKT DRIRRTAEDF 300
    EKEGVFTGSY CINPVTNRRM PVYLANFVLT DYGTGAVMAV PTHDQRDFEF 350
    ARKYDIPMGV VIQPEGEALD PQTMAEAFTA EGIMVNSGRF DGLKSGAAKE 400
    QIADYLEKEG IGKKTVNYRL RDWGISRQRY WGNPIPMIYC DLCGAVPVPE 450
    TDLPVVLPMD ATFTGEGGNP LDKVDSFVNT TCPQCGEAAR RETDTMDTFV 500
    ESSWYFLRYC CPDFVSGPLD KEKTEYWMSV DQYIGGIEHA VMHLLYARFF 550
    TKVLRDLGYC DIDEPFTNLL TQGMVIKDGA KMSKSKGNVV DPNALIDKYG 600
    ADTARLFSLF AAPPEKDLDW SDQGVDGSFR FLNRVWKLVY DTLPIIGGAG 650
    ALDPAGLTNE GKGLRRQVHK TIRKVTEDIE ERFHFNTAIA ATMELVNTIQ 700
    SFEPKNSPQN APVLKEAIES VVMLLAPFVP HFTEELWAQL GNNKSLEQAG 750
    WPAFDSAAAI DEELLVVVQV NGKLRGKLTV AVTASEDDVK GAALADERVK 800
    PFIEGKSVKK IVYVPGKLVN IVVG 824
    Length:824
    Mass (Da):93,456
    Last modified:June 12, 2007 - v1
    Checksum:i5AA28FA742CB2ABA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000698 Genomic DNA. Translation: ABQ27295.1.
    RefSeqiYP_001231868.1. NC_009483.1.

    Genome annotation databases

    EnsemblBacteriaiABQ27295; ABQ27295; Gura_3134.
    GeneIDi5164939.
    KEGGigur:Gura_3134.
    PATRICi22036589. VBIGeoUra13052_3352.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000698 Genomic DNA. Translation: ABQ27295.1 .
    RefSeqi YP_001231868.1. NC_009483.1.

    3D structure databases

    ProteinModelPortali A5G677.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351605.Gura_3134.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ27295 ; ABQ27295 ; Gura_3134 .
    GeneIDi 5164939.
    KEGGi gur:Gura_3134.
    PATRICi 22036589. VBIGeoUra13052_3352.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HELEVYT.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci GURA351605:GI6A-3178-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rf4.

    Entry informationi

    Entry nameiSYL_GEOUR
    AccessioniPrimary (citable) accession number: A5G677
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3