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A5G677

- SYL_GEOUR

UniProt

A5G677 - SYL_GEOUR

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGURA351605:GI6A-3178-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Gura_3134
OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Taxonomic identifieri351605 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000006695: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 824824Leucine--tRNA ligasePRO_1000074835Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351605.Gura_3134.

Structurei

3D structure databases

ProteinModelPortaliA5G677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi581 – 5855"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5G677-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEKYLPSRV EEKWQKFWEA NKSFRATEDK TREKYYLLEM FPYPSGRIHM
60 70 80 90 100
GHVRNYSIGD VIARFKRMKG FNVLHPMGWD AFGMPAENAA IQNKSHPAKW
110 120 130 140 150
TYENIAYMRG QLKKMGLSYD WDRELATCDV DYYKWEQLIF LQMYKKGLAY
160 170 180 190 200
KKISSVNWCP KCETVLANEQ VEDGCCWRCD SNVDQKELEQ WSFRITDYAE
210 220 230 240 250
ELLEYTYKLP GWPERVLTMQ RNWIGRSTGC EIDFPIEGQM DKIKVFTTRQ
260 270 280 290 300
DTLFGATFMS LAPEHPMALE LTTPENMATV AAFIEKVKKT DRIRRTAEDF
310 320 330 340 350
EKEGVFTGSY CINPVTNRRM PVYLANFVLT DYGTGAVMAV PTHDQRDFEF
360 370 380 390 400
ARKYDIPMGV VIQPEGEALD PQTMAEAFTA EGIMVNSGRF DGLKSGAAKE
410 420 430 440 450
QIADYLEKEG IGKKTVNYRL RDWGISRQRY WGNPIPMIYC DLCGAVPVPE
460 470 480 490 500
TDLPVVLPMD ATFTGEGGNP LDKVDSFVNT TCPQCGEAAR RETDTMDTFV
510 520 530 540 550
ESSWYFLRYC CPDFVSGPLD KEKTEYWMSV DQYIGGIEHA VMHLLYARFF
560 570 580 590 600
TKVLRDLGYC DIDEPFTNLL TQGMVIKDGA KMSKSKGNVV DPNALIDKYG
610 620 630 640 650
ADTARLFSLF AAPPEKDLDW SDQGVDGSFR FLNRVWKLVY DTLPIIGGAG
660 670 680 690 700
ALDPAGLTNE GKGLRRQVHK TIRKVTEDIE ERFHFNTAIA ATMELVNTIQ
710 720 730 740 750
SFEPKNSPQN APVLKEAIES VVMLLAPFVP HFTEELWAQL GNNKSLEQAG
760 770 780 790 800
WPAFDSAAAI DEELLVVVQV NGKLRGKLTV AVTASEDDVK GAALADERVK
810 820
PFIEGKSVKK IVYVPGKLVN IVVG
Length:824
Mass (Da):93,456
Last modified:June 12, 2007 - v1
Checksum:i5AA28FA742CB2ABA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA. Translation: ABQ27295.1.
RefSeqiYP_001231868.1. NC_009483.1.

Genome annotation databases

EnsemblBacteriaiABQ27295; ABQ27295; Gura_3134.
GeneIDi5164939.
KEGGigur:Gura_3134.
PATRICi22036589. VBIGeoUra13052_3352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000698 Genomic DNA. Translation: ABQ27295.1 .
RefSeqi YP_001231868.1. NC_009483.1.

3D structure databases

ProteinModelPortali A5G677.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351605.Gura_3134.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ27295 ; ABQ27295 ; Gura_3134 .
GeneIDi 5164939.
KEGGi gur:Gura_3134.
PATRICi 22036589. VBIGeoUra13052_3352.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci GURA351605:GI6A-3178-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rf4.

Entry informationi

Entry nameiSYL_GEOUR
AccessioniPrimary (citable) accession number: A5G677
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3