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A5G460 (ADE_GEOUR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenine deaminase
Short name=ADE
EC=3.5.4.2
Alternative name(s):
Adenine aminohydrolase
Short name=AAH
Gene names
Ordered Locus Names:Gura_2399
OrganismGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens) [Complete proteome] [HAMAP]
Taxonomic identifier351605 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. HAMAP MF_01962

Catalytic activity

Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01962

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_01962

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355Adenine deaminase HAMAP MF_01962
PRO_1000081924

Sites

Active site2071Proton donor By similarity
Metal binding241Zinc; catalytic By similarity
Metal binding261Zinc; catalytic By similarity
Metal binding2041Zinc; catalytic By similarity
Metal binding2851Zinc; catalytic By similarity
Binding site2861Substrate By similarity
Site2281Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
A5G460 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 8B721CB2FE1BD307

FASTA35539,950
        10         20         30         40         50         60 
MNFDCIPRED LHGILCHMPK AELHIHIEGS LEPELIFELA TRNRIQLPYP TIDELRAAYA 

        70         80         90        100        110        120 
FTDLQSFLDI YYAGASVLQK EADFFDMAWA YLKRAKAENV VHAEIFFDPQ THTARGIPFE 

       130        140        150        160        170        180 
TVINGLDRAI RRGREELGLS ASLILCFLRH LSEEDAFAAL EDALPFRDKF IGVGLDSSER 

       190        200        210        220        230        240 
GNPPEKFTRV FARCRELGLR LVAHAGEEGS AEYISHSLDL LKAERIDHGV HCLDDPKLVA 

       250        260        270        280        290        300 
RLVQQRIPLT VCPLSNVKLC VFPSLSAHNI GKLLAAGIAA TINSDDPAYF GGYLNRNYTA 

       310        320        330        340        350 
TFAALPGLGA KEAYQLARNS FEASFVNENI KEGWIRELDE FFTHYRENEG KWLPL

« Hide

References

[1]"Complete sequence of Geobacter uraniireducens Rf4."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Shelobolina E., Aklujkar M., Lovley D., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rf4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000698 Genomic DNA. Translation: ABQ26578.1.
RefSeqYP_001231151.1. NC_009483.1.

3D structure databases

ProteinModelPortalA5G460.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5G460.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5164365.
GenomeReviewsGene locus Gura_2399 in contig CP000698_GR.
KEGGgur:Gura_2399.
NMPDRfig|351605.3.peg.2664.
PATRIC22034974. VBIGeoUra13052_2553.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1816.
HOGENOMHBG630382.
OMAFGGYVDD.
ProtClustDBCLSK2324783.

Enzyme and pathway databases

BioCycGURA351605:GURA_2399-MONOMER.

Family and domain databases

HAMAPMF_01962. Adenine_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameADE_GEOUR
AccessionPrimary (citable) accession number: A5G460
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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