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A5G3H3

- PUR5_GEOUR

UniProt

A5G3H3 - PUR5_GEOUR

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, Gura_2153
Organism
Geobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGURA351605:GI6A-2181-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:Gura_2153
OrganismiGeobacter uraniireducens (strain Rf4) (Geobacter uraniumreducens)
Taxonomic identifieri351605 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000006695: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_1000083459Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351605.Gura_2153.

Structurei

3D structure databases

ProteinModelPortaliA5G3H3.
SMRiA5G3H3. Positions 4-341.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiGEATCEV.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A5G3H3-1 [UniParc]FASTAAdd to Basket

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MSESRITYKD AGVDIDAGNT FVKMIKPLVK ATSRPEVIAD IGGFGGLFSL    50
NSSKYKNPVL VSGTDGVGTK LKIAFLANRH DTIGIDLVAM CVNDIIVQGA 100
EPLFFLDYLA TAKLDPEKGA SIIKGVSEGC IQAGCALIGG ETAEMPGFYS 150
GDEYDMAGFA VGVVDRDKII DGSSITVGNR LIGIASSGLH SNGYSLARKI 200
IFDKMGLGID DIIPGLDKTV ADELLTPTRI YVRSILNLLR DFPINGIAHI 250
TGGGLLENIP RILPNGCKAL VHKNSWQPPP IYQILQNAGN IEENELFRTF 300
NCGIGMVLAV PEKEADEVLI RLSGLNEHAF VIGEIAKCEA GSECVEMI 348
Length:348
Mass (Da):37,143
Last modified:June 12, 2007 - v1
Checksum:i1AC22AB516F50FD7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000698 Genomic DNA. Translation: ABQ26341.1.
RefSeqiYP_001230914.1. NC_009483.1.

Genome annotation databases

EnsemblBacteriaiABQ26341; ABQ26341; Gura_2153.
GeneIDi5165875.
KEGGigur:Gura_2153.
PATRICi22034444. VBIGeoUra13052_2297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000698 Genomic DNA. Translation: ABQ26341.1 .
RefSeqi YP_001230914.1. NC_009483.1.

3D structure databases

ProteinModelPortali A5G3H3.
SMRi A5G3H3. Positions 4-341.
ModBasei Search...

Protein-protein interaction databases

STRINGi 351605.Gura_2153.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ26341 ; ABQ26341 ; Gura_2153 .
GeneIDi 5165875.
KEGGi gur:Gura_2153.
PATRICi 22034444. VBIGeoUra13052_2297.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi GEATCEV.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci GURA351605:GI6A-2181-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rf4.

Entry informationi

Entry nameiPUR5_GEOUR
AccessioniPrimary (citable) accession number: A5G3H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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