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A5G2H9

- ALR_ACICJ

UniProt

A5G2H9 - ALR_ACICJ

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Protein
Alanine racemase
Gene
alr, Acry_2871
Organism
Acidiphilium cryptum (strain JF-5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptor; specific for D-alanine By similarity
Binding sitei130 – 1301Substrate By similarity
Active sitei252 – 2521Proton acceptor; specific for L-alanine By similarity
Binding sitei300 – 3001Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciACRY349163:GHET-2923-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemase (EC:5.1.1.1)
Gene namesi
Name:alr
Ordered Locus Names:Acry_2871
OrganismiAcidiphilium cryptum (strain JF-5)
Taxonomic identifieri349163 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
ProteomesiUP000000245: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Alanine racemaseUniRule annotation
PRO_1000138578Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi349163.Acry_2871.

Structurei

3D structure databases

ProteinModelPortaliA5G2H9.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiRIGISIY.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5G2H9-1 [UniParc]FASTAAdd to Basket

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MNHPTLTIDP GAVAANWQAL AARHTGEVAG VVKADAYGLG AALIAPALAA    50
AGCRSFFVAT LDEALSLRAL LPAARIGVLN GCPPGEEGTM RARELRPVLG 100
SLAACARWRG AAGDDKAPPS FLHLDTGMNR LGLDRDEAAH LIAHPTLLDG 150
LGLTHVMTHL VAAEEPDASA NAAQRERFAA FAARFPWLRT SLANSSGLFL 200
GPGFGSDLAR PGYALYGGNP TPTAANPMRP AIALAAPILQ IRAIASGETV 250
GYNGTWRAAR PSRIATIGVG YADGLPRSLS NRLTARWQGK IIPVAGRLSM 300
DLTTFDVTDH PDIAPGDVIE LIGPGHDIDA FAAEAGTIGY EILTSLGPRY 350
RRVVKSV 357
Length:357
Mass (Da):37,235
Last modified:June 12, 2007 - v1
Checksum:i2425E24F1674BF0C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000697 Genomic DNA. Translation: ABQ32061.1.
RefSeqiWP_012040378.1. NC_009484.1.
YP_001235980.1. NC_009484.1.

Genome annotation databases

EnsemblBacteriaiABQ32061; ABQ32061; Acry_2871.
GeneIDi5159502.
KEGGiacr:Acry_2871.
PATRICi20650872. VBIAciCry6074_3392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000697 Genomic DNA. Translation: ABQ32061.1 .
RefSeqi WP_012040378.1. NC_009484.1.
YP_001235980.1. NC_009484.1.

3D structure databases

ProteinModelPortali A5G2H9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349163.Acry_2871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ32061 ; ABQ32061 ; Acry_2871 .
GeneIDi 5159502.
KEGGi acr:Acry_2871.
PATRICi 20650872. VBIAciCry6074_3392.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031445.
KOi K01775.
OMAi RIGISIY.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci ACRY349163:GHET-2923-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JF-5.

Entry informationi

Entry nameiALR_ACICJ
AccessioniPrimary (citable) accession number: A5G2H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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