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A5G276

- FTHS_ACICJ

UniProt

A5G276 - FTHS_ACICJ

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Acidiphilium cryptum (strain JF-5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciACRY349163:GHET-2817-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Acry_2767
    OrganismiAcidiphilium cryptum (strain JF-5)
    Taxonomic identifieri349163 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
    ProteomesiUP000000245: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_1000068787Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349163.Acry_2767.

    Structurei

    3D structure databases

    ProteinModelPortaliA5G276.
    SMRiA5G276. Positions 4-555.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5G276-1 [UniParc]FASTAAdd to Basket

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    MASDLDIARA SRLRPIGEIA AAAGIPAEAL IPYGRYKGKV DGGFIRSLED    50
    RPDGALVLVV GISPTPAGEG KTTTSIGLGD ALRAAGAKAM IALREPSLGP 100
    CFGQKGGATG GGRAQVAPME EINLHFTGDF HAITSANNLL AAMLDNHVYW 150
    GNELGIDPRR IAFRRAIDMN DRALRQTVLG LGDGANGAAR EQKFDITVAS 200
    EVMAIFCLAR DLDDLQRRLA RIVVAERRDG SPVTPADLKA VGAMAALLRD 250
    ALQPNLVQTL EGTPALVHGG PFANIAHGCN SVIATRTALK LADIVVTEAG 300
    FGADLGGEKF LDIKCRQAGL APSCAVVVAT IRALKMHAGV AKADLGAENP 350
    GAVARGAANL RRHVAAMRAF GLPVIVAING FVTDTGAERE ALRAALDEDG 400
    GARICFCTHW ADGSAGATDL AQAVIETIAA KSARFAPLYP DDMKLPHKLR 450
    TIAQRIYGAD DIELSPLAAK RLARFEAQGY DHLPVCVAKT QYSFTADPAR 500
    RGAPTGFTVP IRDARLSAGA GFVVALAGDV MTMPGLPRIP AAEAIGLDPD 550
    GAIHGLF 557
    Length:557
    Mass (Da):58,079
    Last modified:June 12, 2007 - v1
    Checksum:i3DAD16EE4068CE7E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000697 Genomic DNA. Translation: ABQ31958.1.
    RefSeqiYP_001235877.1. NC_009484.1.

    Genome annotation databases

    EnsemblBacteriaiABQ31958; ABQ31958; Acry_2767.
    GeneIDi5160043.
    KEGGiacr:Acry_2767.
    PATRICi20650662. VBIAciCry6074_3289.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000697 Genomic DNA. Translation: ABQ31958.1 .
    RefSeqi YP_001235877.1. NC_009484.1.

    3D structure databases

    ProteinModelPortali A5G276.
    SMRi A5G276. Positions 4-555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349163.Acry_2767.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ31958 ; ABQ31958 ; Acry_2767 .
    GeneIDi 5160043.
    KEGGi acr:Acry_2767.
    PATRICi 20650662. VBIAciCry6074_3289.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci ACRY349163:GHET-2817-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JF-5.

    Entry informationi

    Entry nameiFTHS_ACICJ
    AccessioniPrimary (citable) accession number: A5G276
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3