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A5G276 (FTHS_ACICJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Acry_2767
OrganismAcidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]
Taxonomic identifier349163 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000068787

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A5G276 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 3DAD16EE4068CE7E

FASTA55758,079
        10         20         30         40         50         60 
MASDLDIARA SRLRPIGEIA AAAGIPAEAL IPYGRYKGKV DGGFIRSLED RPDGALVLVV 

        70         80         90        100        110        120 
GISPTPAGEG KTTTSIGLGD ALRAAGAKAM IALREPSLGP CFGQKGGATG GGRAQVAPME 

       130        140        150        160        170        180 
EINLHFTGDF HAITSANNLL AAMLDNHVYW GNELGIDPRR IAFRRAIDMN DRALRQTVLG 

       190        200        210        220        230        240 
LGDGANGAAR EQKFDITVAS EVMAIFCLAR DLDDLQRRLA RIVVAERRDG SPVTPADLKA 

       250        260        270        280        290        300 
VGAMAALLRD ALQPNLVQTL EGTPALVHGG PFANIAHGCN SVIATRTALK LADIVVTEAG 

       310        320        330        340        350        360 
FGADLGGEKF LDIKCRQAGL APSCAVVVAT IRALKMHAGV AKADLGAENP GAVARGAANL 

       370        380        390        400        410        420 
RRHVAAMRAF GLPVIVAING FVTDTGAERE ALRAALDEDG GARICFCTHW ADGSAGATDL 

       430        440        450        460        470        480 
AQAVIETIAA KSARFAPLYP DDMKLPHKLR TIAQRIYGAD DIELSPLAAK RLARFEAQGY 

       490        500        510        520        530        540 
DHLPVCVAKT QYSFTADPAR RGAPTGFTVP IRDARLSAGA GFVVALAGDV MTMPGLPRIP 

       550 
AAEAIGLDPD GAIHGLF 

« Hide

References

[1]"Complete sequence of chromosome of Acidiphilium cryptum JF-5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JF-5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000697 Genomic DNA. Translation: ABQ31958.1.
RefSeqYP_001235877.1. NC_009484.1.

3D structure databases

ProteinModelPortalA5G276.
SMRA5G276. Positions 4-555.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349163.Acry_2767.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ31958; ABQ31958; Acry_2767.
GeneID5160043.
KEGGacr:Acry_2767.
PATRIC20650662. VBIAciCry6074_3289.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycACRY349163:GHET-2817-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_ACICJ
AccessionPrimary (citable) accession number: A5G276
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways