SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A5G276

- FTHS_ACICJ

UniProt

A5G276 - FTHS_ACICJ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Acry_2767
Organism
Acidiphilium cryptum (strain JF-5)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACRY349163:GHET-2817-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Acry_2767
OrganismiAcidiphilium cryptum (strain JF-5)
Taxonomic identifieri349163 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
ProteomesiUP000000245: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000068787Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349163.Acry_2767.

Structurei

3D structure databases

ProteinModelPortaliA5G276.
SMRiA5G276. Positions 4-555.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5G276-1 [UniParc]FASTAAdd to Basket

« Hide

MASDLDIARA SRLRPIGEIA AAAGIPAEAL IPYGRYKGKV DGGFIRSLED    50
RPDGALVLVV GISPTPAGEG KTTTSIGLGD ALRAAGAKAM IALREPSLGP 100
CFGQKGGATG GGRAQVAPME EINLHFTGDF HAITSANNLL AAMLDNHVYW 150
GNELGIDPRR IAFRRAIDMN DRALRQTVLG LGDGANGAAR EQKFDITVAS 200
EVMAIFCLAR DLDDLQRRLA RIVVAERRDG SPVTPADLKA VGAMAALLRD 250
ALQPNLVQTL EGTPALVHGG PFANIAHGCN SVIATRTALK LADIVVTEAG 300
FGADLGGEKF LDIKCRQAGL APSCAVVVAT IRALKMHAGV AKADLGAENP 350
GAVARGAANL RRHVAAMRAF GLPVIVAING FVTDTGAERE ALRAALDEDG 400
GARICFCTHW ADGSAGATDL AQAVIETIAA KSARFAPLYP DDMKLPHKLR 450
TIAQRIYGAD DIELSPLAAK RLARFEAQGY DHLPVCVAKT QYSFTADPAR 500
RGAPTGFTVP IRDARLSAGA GFVVALAGDV MTMPGLPRIP AAEAIGLDPD 550
GAIHGLF 557
Length:557
Mass (Da):58,079
Last modified:June 12, 2007 - v1
Checksum:i3DAD16EE4068CE7E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000697 Genomic DNA. Translation: ABQ31958.1.
RefSeqiYP_001235877.1. NC_009484.1.

Genome annotation databases

EnsemblBacteriaiABQ31958; ABQ31958; Acry_2767.
GeneIDi5160043.
KEGGiacr:Acry_2767.
PATRICi20650662. VBIAciCry6074_3289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000697 Genomic DNA. Translation: ABQ31958.1 .
RefSeqi YP_001235877.1. NC_009484.1.

3D structure databases

ProteinModelPortali A5G276.
SMRi A5G276. Positions 4-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349163.Acry_2767.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ31958 ; ABQ31958 ; Acry_2767 .
GeneIDi 5160043.
KEGGi acr:Acry_2767.
PATRICi 20650662. VBIAciCry6074_3289.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci ACRY349163:GHET-2817-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JF-5.

Entry informationi

Entry nameiFTHS_ACICJ
AccessioniPrimary (citable) accession number: A5G276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi