Reviewed, UniProtKB/Swiss-Prot A5G270 (AROE_ACICJ)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Acry_2761

Organism

Acidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]

Taxonomic identifier

349163 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7.
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Shikimate dehydrogenase		PRO_1000021252
Regions
	Nucleotide binding	131 – 135	5	NADP By similarity
Sites
	Active site	71	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	A5G270-1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 1F7F6F90AFBA529F	FASTA	276	28,086
	10 20 30 40 50 60 MILSGHARLA GVIGYPVAHS RSPRLHGTWL ERHGIDGAYL PLAIAPDDFA ACVAALAKMG 70 80 90 100 110 120 FAGANVTIPH KEAAFAVCDR VADSARRAGA VNTLVFTPTG IEGANTDGSG FLANLRAHGV 130 140 150 160 170 180 NPAAGPALVL GAGGAARAIA TALQDAGAVV TLCNRSPERA VALARDFGLV HIPWEARSAA 190 200 210 220 230 240 LADHALVVNT TSLGMAGHNP LELDLARAAP GMAVADIVYV PLETPLLAAA RARGLVAVEG 250 260 270 LGMLLHQAVP GFAAWFGVTP VVDDALYRAV AADLMG

References

[1]

"Complete sequence of chromosome of Acidiphilium cryptum JF-5." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000697 Genomic DNA. Translation: ABQ31952.1.
RefSeq	YP_001235871.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5160011.
GenomeReviews	Gene locus Acry_2761 in contig CP000697_GR.
KEGG	acr:Acry_2761.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd. IPR011342. Quinate/shikimate_5-DHase. IPR013708. Shikimate_DHase-bd_N. IPR006151. Shikm_DHase/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_ACICJ

Accession

Primary (citable) accession number: A5G270

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 12, 2007
Last modified:	November 25, 2008
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)