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A5G146 (GLPK_ACICJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:Acry_2384
OrganismAcidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]
Taxonomic identifier349163 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 499499Glycerol kinase HAMAP MF_00186
PRO_1000020692

Regions

Nucleotide binding412 – 4165ATP By similarity

Sites

Binding site121Substrate By similarity
Binding site161ATP By similarity
Binding site821Substrate By similarity
Binding site1341Substrate By similarity
Binding site2451Substrate By similarity
Binding site2671ATP By similarity
Binding site3111ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
A5G146 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: CDC328B0FFBECE21

FASTA49954,375
        10         20         30         40         50         60 
MSRYVGAIDQ GTTSSRFIVF DKGGNIVSVA QKEHRQIYPK PGWVEHDPME ILSNTNEVIG 

        70         80         90        100        110        120 
AALARANLTA SDLAAVGITN QRETTLLWDR KTGQPLCNAL VWMDTRTDQL VQQFTRDGGQ 

       130        140        150        160        170        180 
DRFRAKTGLP LATYFAGLKL RWILDNVEGA KAKAEAGDAL FGTVDSWLTW NLTGGVNGGH 

       190        200        210        220        230        240 
HVTDVTNASR TMLIDLATCA WDDDMLNAFG IPRACLPKIV PSSAVYGEIR TAPLQGTKLA 

       250        260        270        280        290        300 
GMLGDQQAAL VGQTCFAPGE AKNTYGTGSF LLMNTGTEPV QSKAGLLTTL AYQLGDEKPR 

       310        320        330        340        350        360 
YALEGAIAIT GALVQWLRDN LKLFDVAPQI EPLARSVEDN GDVYIVPAFS GLYAPYWKDD 

       370        380        390        400        410        420 
ARGVIAGLTR YATRAHLARA ALESTAYQVR DVVEAMQEDS GIRLAALKTD GGMVANELLM 

       430        440        450        460        470        480 
QFQADILNAP VVRPKMTETT ALGAAYAAGL AVGYWANLED LRANWGVDKT WEPSMPAETR 

       490 
EKYYRSWKKA VQRSFAWVD

« Hide

References

[1]"Complete sequence of chromosome of Acidiphilium cryptum JF-5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JF-5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000697 Genomic DNA. Translation: ABQ31578.1.
RefSeqYP_001235497.1. NC_009484.1.

3D structure databases

ProteinModelPortalA5G146.
SMRA5G146. Positions 4-499.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5G146.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5160767.
GenomeReviewsGene locus Acry_2384 in contig CP000697_GR.
KEGGacr:Acry_2384.
PATRIC20649860. VBIAciCry6074_2892.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0554.
HOGENOMHBG511469.
OMAATYFSGT.
ProtClustDBCLSK971289.

Enzyme and pathway databases

BioCycACRY349163:ACRY_2384-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. False negative.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_ACICJ
AccessionPrimary (citable) accession number: A5G146
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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