A5G0Y2 (IOLG_ACICJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Acry_2320

Organism

Acidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]

Taxonomic identifier

349163 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium › Acidiphilium cryptum

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP-Rule MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP-Rule MF_01671
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the Gfo/Idh/MocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Inositol 2-dehydrogenase HAMAP-Rule MF_01671		PRO_0000352548

Sequences

	Sequence		Length	Mass (Da)
	A5G0Y2 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: ED3663F0F4C53C6B	FASTA	336	36,467
	10 20 30 40 50 60 MTLRIGVIGT GAIGRDHMRR INQTLSGAKV TAVSDVNIES VRTARADLAP EAEVVGSGEE 70 80 90 100 110 120 VAASAGVDAV VVTSWGATHE QYVLAAIAAG KPVFCEKPLS TTAAGAGRIV EAETAFGRRL 130 140 150 160 170 180 VQVGFMRRYD AGYRMLKAVV ENEIGRPLMV HAAHRNPSVP EQYITPMAIQ DTLIHEIDVL 190 200 210 220 230 240 RWLLDDDYVS AQVISPRRTR HAHARVEDPQ IVLLETKSGI RIDVEIFVNC RYGYDIQCQV 250 260 270 280 290 300 VGEEGLASLP DPMAVVMRKD AKLQSAIMTD WKDRFIDSYD LELQDFIKAA ARGTASGPTA 310 320 330 WDGYVAAVSS DACVEAQSRP GSIVPISLPA RPPLYN

References

[1]

"Complete sequence of chromosome of Acidiphilium cryptum JF-5." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JF-5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000697 Genomic DNA. Translation: ABQ31514.1.
RefSeq	YP_001235433.1. NC_009484.1.
3D structure databases
ProteinModelPortal	A5G0Y2.
ModBase	Search...
Protein-protein interaction databases
STRING	349163.Acry_2320.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABQ31514; ABQ31514; Acry_2320.
GeneID	5159860.
KEGG	acr:Acry_2320.
PATRIC	20649720. VBIAciCry6074_2828.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HOG000227439.
KO	K00010.
OMA	YDVELQD.
ProtClustDB	CLSK800746.
Enzyme and pathway databases
BioCyc	ACRY349163:GHET-2374-MONOMER.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_01671. IolG.
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_ACICJ

Accession

Primary (citable) accession number: A5G0Y2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	June 12, 2007
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program