Reviewed, UniProtKB/Swiss-Prot A5G0Y2 (IOLG_ACICJ)

Names and origin

Protein names

Recommended name:
    Inositol 2-dehydrogenase
    EC=1.1.1.18
Alternative name(s):
    Myo-inositol 2-dehydrogenase
      Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Acry_2320

Organism

Acidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]

Taxonomic identifier

349163 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity.
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352548

Sequences

	Sequence		Length	Mass (Da)
	A5G0Y2-1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: ED3663F0F4C53C6B	FASTA	336	36,467
	10 20 30 40 50 60 MTLRIGVIGT GAIGRDHMRR INQTLSGAKV TAVSDVNIES VRTARADLAP EAEVVGSGEE 70 80 90 100 110 120 VAASAGVDAV VVTSWGATHE QYVLAAIAAG KPVFCEKPLS TTAAGAGRIV EAETAFGRRL 130 140 150 160 170 180 VQVGFMRRYD AGYRMLKAVV ENEIGRPLMV HAAHRNPSVP EQYITPMAIQ DTLIHEIDVL 190 200 210 220 230 240 RWLLDDDYVS AQVISPRRTR HAHARVEDPQ IVLLETKSGI RIDVEIFVNC RYGYDIQCQV 250 260 270 280 290 300 VGEEGLASLP DPMAVVMRKD AKLQSAIMTD WKDRFIDSYD LELQDFIKAA ARGTASGPTA 310 320 330 WDGYVAAVSS DACVEAQSRP GSIVPISLPA RPPLYN

References

[1]

"Complete sequence of chromosome of Acidiphilium cryptum JF-5." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000697 Genomic DNA. Translation: ABQ31514.1.
RefSeq	YP_001235433.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A5G0Y2.
Genome annotation databases
GeneID	5159860.
GenomeReviews	Gene locus Acry_2320 in contig CP000697_GR.
KEGG	acr:Acry_2320.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	DWKDRFI.
Family and domain databases
HAMAP	MF_01671. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_ACICJ

Accession

Primary (citable) accession number: A5G0Y2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	June 12, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)