Reviewed, UniProtKB/Swiss-Prot A5G0G0 (ARGB_ACICJ)

Names and origin

Protein names

Recommended name:
    Acetylglutamate kinase
    EC=2.7.2.8
Alternative name(s):
    NAG kinase
      Short name=AGK
    N-acetyl-L-glutamate 5-phosphotransferase

Gene names

Name:	argB
Ordered Locus Names:	Acry_2143

Organism

Acidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]

Taxonomic identifier

349163 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP acetylglutamate kinase activity Inferred from electronic annotation. Source: HAMAP glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Acetylglutamate kinase HAMAP MF_00082		PRO_0000335601
Regions
	Region	70 – 71	2	Substrate binding By similarity
Sites
	Binding site	92	1	Substrate By similarity
	Binding site	197	1	Substrate By similarity
	Site	35	1	Transition state stabilizer By similarity
	Site	257	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5G0G0-1 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: ED1DC90D5561E83C	FASTA	299	30,949
	10 20 30 40 50 60 MTISDRHADA AEQARIVALA LPYLRRYAGA TIVVKYGGHA MGEESLAEEF GRDIALLKQV 70 80 90 100 110 120 GINPVVVHGG GPQINAMLKR LAIQSTFVDG LRVTDAAMVE VVEMVLAGTV NKMVAGLINR 130 140 150 160 170 180 AGALAVGICG KDGGLIRARK LTRTRRDPEG AIERALDLGF VGEPEHVDVR VIHALTGAGL 190 200 210 220 230 240 IPVVAPVGVG ADGATYNINA DTVAGAIAGA LGANRLLMLT DVAGVLDRNG KLIPDLSIAE 250 260 270 280 290 VEALRADGTI SGGMIPKVET CIEAVRQGVK GATIVDGRVP HACLLELFTE GGIGTLIHA

References

[1]

"Complete sequence of chromosome of Acidiphilium cryptum JF-5." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000697 Genomic DNA. Translation: ABQ31342.1. Different initiation.
RefSeq	YP_001235261.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A5G0G0.
Genome annotation databases
GeneID	5162081.
GenomeReviews	Gene locus Acry_2143 in contig CP000697_GR.
KEGG	acr:Acry_2143.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00082. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR011148. GlcNAc_kinase. IPR001057. Glu_5kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
TIGRFAMs	TIGR00761. argB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_ACICJ

Accession

Primary (citable) accession number: A5G0G0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	September 1, 2009
This is version 16 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)