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A5G068

- SYL_ACICJ

UniProt

A5G068 - SYL_ACICJ

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Acidiphilium cryptum (strain JF-5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei625 – 6251ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciACRY349163:GHET-2087-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Acry_2050
    OrganismiAcidiphilium cryptum (strain JF-5)
    Taxonomic identifieri349163 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
    ProteomesiUP000000245: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 864864Leucine--tRNA ligasePRO_0000334723Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349163.Acry_2050.

    Structurei

    3D structure databases

    ProteinModelPortaliA5G068.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi50 – 6011"HIGH" regionAdd
    BLAST
    Motifi622 – 6265"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5G068-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQTTHDASA YDFTAAEARW QAAWEARNCF ATADAPQGGR RKCYVLEMFP    50
    YPSGKIHMGH VRNYAIGDVI ARARRAQGYD VLHPMGWDAF GLPAENAARE 100
    RNVDPAKWTR DNIAAMKADL KRVGLSVDWS REFATCDPEY YGHQQKLFLD 150
    LWRAGLAYRR ESAVNWDPVD MTVLANEQVI DGRGWKSGAP VEKRKLRQWF 200
    FRITDFAADL LAGLDTLENW PERVRTMQRN WIGRSEGAEF TIRLAAPCGG 250
    IESVPVYSTR PDTLFGMSFV ALAPDHPLAT AVAAANPEAA AFIAECQSAG 300
    TSEAAIEAAE KRGFDTGLRV VHPFDPSRTH PVWIANFVLM DYGTGAIFGC 350
    PAHDQRDLDF ARKYGLDVTV VVAPKDDPGL AVGDVAFTGD GVIVNSGFLD 400
    GLDVAAAKSR AIAELESRGA GKGVVNWRLR DWGVSRQRAW GCPIPMIHCE 450
    VCGTVPVPEK DLPVRLPDDL PFDRPGNALD HHPSWKHVAC PQCGAAAQRE 500
    TDTFDTFVDS SWYFARFCAP HAPVPADPAA TSHWMPVDHY IGGIEHAILH 550
    LLYARFFTRA MHRLGQVGVA EPFAGLFTQG MLTHESYRTE DGKWLYPEEV 600
    IRHADHATTL DGRKVIVGPI EKMSKSKRNT VDPSAVIARF GADTARWFVL 650
    SDNPPERDVE WTEAGAQGAF RYVQRLYRLA RSVAADRADD VALERAEGEA 700
    RKLRQATHRT IAAVTEAIDG FAFNVAIARL YELANAIAET EGRDAPGLPA 750
    ARREAMSALI RLAAPIIPHV AEEANAQVSP EAGLVVNQPW PVAEPELLKR 800
    DSVTLAVQIM GKLRGTIELP PGADAETAIA AAMAEPRIAQ LLEGATIVKR 850
    IHVPDRIVNF VVRP 864
    Length:864
    Mass (Da):95,028
    Last modified:June 12, 2007 - v1
    Checksum:i59F41020AFB4B9E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000697 Genomic DNA. Translation: ABQ31250.1.
    RefSeqiYP_001235169.1. NC_009484.1.

    Genome annotation databases

    EnsemblBacteriaiABQ31250; ABQ31250; Acry_2050.
    GeneIDi5161511.
    KEGGiacr:Acry_2050.
    PATRICi20649168. VBIAciCry6074_2555.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000697 Genomic DNA. Translation: ABQ31250.1 .
    RefSeqi YP_001235169.1. NC_009484.1.

    3D structure databases

    ProteinModelPortali A5G068.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349163.Acry_2050.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ31250 ; ABQ31250 ; Acry_2050 .
    GeneIDi 5161511.
    KEGGi acr:Acry_2050.
    PATRICi 20649168. VBIAciCry6074_2555.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci ACRY349163:GHET-2087-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JF-5.

    Entry informationi

    Entry nameiSYL_ACICJ
    AccessioniPrimary (citable) accession number: A5G068
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3