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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Acidiphilium cryptum (strain JF-5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei625 – 6251ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACRY349163:GHET-2087-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Acry_2050
OrganismiAcidiphilium cryptum (strain JF-5)
Taxonomic identifieri349163 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
ProteomesiUP000000245 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Leucine--tRNA ligasePRO_0000334723Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349163.Acry_2050.

Structurei

3D structure databases

ProteinModelPortaliA5G068.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi50 – 6011"HIGH" regionAdd
BLAST
Motifi622 – 6265"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5G068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQTTHDASA YDFTAAEARW QAAWEARNCF ATADAPQGGR RKCYVLEMFP
60 70 80 90 100
YPSGKIHMGH VRNYAIGDVI ARARRAQGYD VLHPMGWDAF GLPAENAARE
110 120 130 140 150
RNVDPAKWTR DNIAAMKADL KRVGLSVDWS REFATCDPEY YGHQQKLFLD
160 170 180 190 200
LWRAGLAYRR ESAVNWDPVD MTVLANEQVI DGRGWKSGAP VEKRKLRQWF
210 220 230 240 250
FRITDFAADL LAGLDTLENW PERVRTMQRN WIGRSEGAEF TIRLAAPCGG
260 270 280 290 300
IESVPVYSTR PDTLFGMSFV ALAPDHPLAT AVAAANPEAA AFIAECQSAG
310 320 330 340 350
TSEAAIEAAE KRGFDTGLRV VHPFDPSRTH PVWIANFVLM DYGTGAIFGC
360 370 380 390 400
PAHDQRDLDF ARKYGLDVTV VVAPKDDPGL AVGDVAFTGD GVIVNSGFLD
410 420 430 440 450
GLDVAAAKSR AIAELESRGA GKGVVNWRLR DWGVSRQRAW GCPIPMIHCE
460 470 480 490 500
VCGTVPVPEK DLPVRLPDDL PFDRPGNALD HHPSWKHVAC PQCGAAAQRE
510 520 530 540 550
TDTFDTFVDS SWYFARFCAP HAPVPADPAA TSHWMPVDHY IGGIEHAILH
560 570 580 590 600
LLYARFFTRA MHRLGQVGVA EPFAGLFTQG MLTHESYRTE DGKWLYPEEV
610 620 630 640 650
IRHADHATTL DGRKVIVGPI EKMSKSKRNT VDPSAVIARF GADTARWFVL
660 670 680 690 700
SDNPPERDVE WTEAGAQGAF RYVQRLYRLA RSVAADRADD VALERAEGEA
710 720 730 740 750
RKLRQATHRT IAAVTEAIDG FAFNVAIARL YELANAIAET EGRDAPGLPA
760 770 780 790 800
ARREAMSALI RLAAPIIPHV AEEANAQVSP EAGLVVNQPW PVAEPELLKR
810 820 830 840 850
DSVTLAVQIM GKLRGTIELP PGADAETAIA AAMAEPRIAQ LLEGATIVKR
860
IHVPDRIVNF VVRP
Length:864
Mass (Da):95,028
Last modified:June 12, 2007 - v1
Checksum:i59F41020AFB4B9E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000697 Genomic DNA. Translation: ABQ31250.1.
RefSeqiWP_012039777.1. NC_009484.1.
YP_001235169.1. NC_009484.1.

Genome annotation databases

EnsemblBacteriaiABQ31250; ABQ31250; Acry_2050.
KEGGiacr:Acry_2050.
PATRICi20649168. VBIAciCry6074_2555.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000697 Genomic DNA. Translation: ABQ31250.1.
RefSeqiWP_012039777.1. NC_009484.1.
YP_001235169.1. NC_009484.1.

3D structure databases

ProteinModelPortaliA5G068.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349163.Acry_2050.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ31250; ABQ31250; Acry_2050.
KEGGiacr:Acry_2050.
PATRICi20649168. VBIAciCry6074_2555.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciACRY349163:GHET-2087-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JF-5.

Entry informationi

Entry nameiSYL_ACICJ
AccessioniPrimary (citable) accession number: A5G068
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: May 27, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.