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A5G068

- SYL_ACICJ

UniProt

A5G068 - SYL_ACICJ

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Protein
Leucine--tRNA ligase
Gene
leuS, Acry_2050
Organism
Acidiphilium cryptum (strain JF-5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei625 – 6251ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACRY349163:GHET-2087-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Acry_2050
OrganismiAcidiphilium cryptum (strain JF-5)
Taxonomic identifieri349163 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
ProteomesiUP000000245: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Leucine--tRNA ligaseUniRule annotation
PRO_0000334723Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349163.Acry_2050.

Structurei

3D structure databases

ProteinModelPortaliA5G068.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi50 – 6011"HIGH" regionUniRule annotation
Add
BLAST
Motifi622 – 6265"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5G068-1 [UniParc]FASTAAdd to Basket

« Hide

MDQTTHDASA YDFTAAEARW QAAWEARNCF ATADAPQGGR RKCYVLEMFP    50
YPSGKIHMGH VRNYAIGDVI ARARRAQGYD VLHPMGWDAF GLPAENAARE 100
RNVDPAKWTR DNIAAMKADL KRVGLSVDWS REFATCDPEY YGHQQKLFLD 150
LWRAGLAYRR ESAVNWDPVD MTVLANEQVI DGRGWKSGAP VEKRKLRQWF 200
FRITDFAADL LAGLDTLENW PERVRTMQRN WIGRSEGAEF TIRLAAPCGG 250
IESVPVYSTR PDTLFGMSFV ALAPDHPLAT AVAAANPEAA AFIAECQSAG 300
TSEAAIEAAE KRGFDTGLRV VHPFDPSRTH PVWIANFVLM DYGTGAIFGC 350
PAHDQRDLDF ARKYGLDVTV VVAPKDDPGL AVGDVAFTGD GVIVNSGFLD 400
GLDVAAAKSR AIAELESRGA GKGVVNWRLR DWGVSRQRAW GCPIPMIHCE 450
VCGTVPVPEK DLPVRLPDDL PFDRPGNALD HHPSWKHVAC PQCGAAAQRE 500
TDTFDTFVDS SWYFARFCAP HAPVPADPAA TSHWMPVDHY IGGIEHAILH 550
LLYARFFTRA MHRLGQVGVA EPFAGLFTQG MLTHESYRTE DGKWLYPEEV 600
IRHADHATTL DGRKVIVGPI EKMSKSKRNT VDPSAVIARF GADTARWFVL 650
SDNPPERDVE WTEAGAQGAF RYVQRLYRLA RSVAADRADD VALERAEGEA 700
RKLRQATHRT IAAVTEAIDG FAFNVAIARL YELANAIAET EGRDAPGLPA 750
ARREAMSALI RLAAPIIPHV AEEANAQVSP EAGLVVNQPW PVAEPELLKR 800
DSVTLAVQIM GKLRGTIELP PGADAETAIA AAMAEPRIAQ LLEGATIVKR 850
IHVPDRIVNF VVRP 864
Length:864
Mass (Da):95,028
Last modified:June 12, 2007 - v1
Checksum:i59F41020AFB4B9E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000697 Genomic DNA. Translation: ABQ31250.1.
RefSeqiYP_001235169.1. NC_009484.1.

Genome annotation databases

EnsemblBacteriaiABQ31250; ABQ31250; Acry_2050.
GeneIDi5161511.
KEGGiacr:Acry_2050.
PATRICi20649168. VBIAciCry6074_2555.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000697 Genomic DNA. Translation: ABQ31250.1 .
RefSeqi YP_001235169.1. NC_009484.1.

3D structure databases

ProteinModelPortali A5G068.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349163.Acry_2050.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ31250 ; ABQ31250 ; Acry_2050 .
GeneIDi 5161511.
KEGGi acr:Acry_2050.
PATRICi 20649168. VBIAciCry6074_2555.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ACRY349163:GHET-2087-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JF-5.

Entry informationi

Entry nameiSYL_ACICJ
AccessioniPrimary (citable) accession number: A5G068
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi