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Protein

Catalase-peroxidase

Gene

katG

Organism
Acidiphilium cryptum (strain JF-5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei93Transition state stabilizerUniRule annotation1
Active sitei97Proton acceptorUniRule annotation1
Metal bindingi260Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3597. AcrCP01_JF-5.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Acry_1851
OrganismiAcidiphilium cryptum (strain JF-5)
Taxonomic identifieri349163 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
Proteomesi
  • UP000000245 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19UniRule annotationAdd BLAST19
ChainiPRO_000035470820 – 728Catalase-peroxidaseAdd BLAST709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki96 ↔ 219Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-245)UniRule annotation
Cross-linki219 ↔ 245Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi349163.Acry_1851.

Structurei

3D structure databases

ProteinModelPortaliA5FZM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5FZM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEAKCPVT GGATRSSSAG IQSNADWWPN QINLGMLHQH SALSNPMDPD
60 70 80 90 100
FDYAAEFKTL DLDAVIADLK ALMTDSQDWW PADFGHYGPL FVRMAWHAAG
110 120 130 140 150
TYRIGDGRGG AGAGQQRFAP LNSWPDNANL DKARRLLWPV KQKYGRKISW
160 170 180 190 200
ADLMVLAGNV ALESMGFKTF GFGAGRVDTW EPDQGIYWGP ETTWLDDKRY
210 220 230 240 250
SGDRDLENPL AAVQMGLIYV NPEGPNGKPD PVAAARDIRE TFARMAMNDE
260 270 280 290 300
ETVALIAGGH TFGKTHGAGD AALVGPEPEA APIEQQGLGW ISSYGTGKGS
310 320 330 340 350
DAITGGPEVT WTQTPTQWSN FYFDNLFNYE WELTKSPAGA WQWVAKDAGD
360 370 380 390 400
VIPDAFDAAK KHRPTMLTTD LSMRMDPAYE KISRRFHQNP DEFADAFARA
410 420 430 440 450
WFKLTHRDMG PVSRYLGKLV PAEHLIWQDP VPAVDHKLID AADIAALKAK
460 470 480 490 500
LLATGIAPTR LALTAWASAA TFRGSDKRGG ANGARIRLAP QKDWAANEPA
510 520 530 540 550
ELAKVLAALE KVQAEFNAAA TGGKKVSLAD LIVLGGCAAI EAAAKAAGHD
560 570 580 590 600
VTVPFTPGRT DATEAQTDVA SFAVLEPKAD GFRNYLGKGD PRAPEEQLID
610 620 630 640 650
RAQLMTLTAP EMTALIGGMR ALGANVGGAK HGVFTTRPGA LTNDFFVNLL
660 670 680 690 700
DMNMSWHPAA EPGVYELRDR KSGAVKWTAT RVDLVFGSNS QLRALAEVYG
710 720
TQDGEAAFVK DFVAAWTKVM ELDRFDLA
Length:728
Mass (Da):78,868
Last modified:June 12, 2007 - v1
Checksum:i61E17724CD363C4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000697 Genomic DNA. Translation: ABQ31053.1.
RefSeqiWP_007423989.1. NC_009484.1.

Genome annotation databases

EnsemblBacteriaiABQ31053; ABQ31053; Acry_1851.
KEGGiacr:Acry_1851.
PATRICi20648746. VBIAciCry6074_2346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000697 Genomic DNA. Translation: ABQ31053.1.
RefSeqiWP_007423989.1. NC_009484.1.

3D structure databases

ProteinModelPortaliA5FZM1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349163.Acry_1851.

Protein family/group databases

PeroxiBasei3597. AcrCP01_JF-5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ31053; ABQ31053; Acry_1851.
KEGGiacr:Acry_1851.
PATRICi20648746. VBIAciCry6074_2346.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_ACICJ
AccessioniPrimary (citable) accession number: A5FZM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: June 12, 2007
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.