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A5FZK3 (A5FZK3_ACICJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
EC=2.2.1.7 HAMAP MF_00315
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase HAMAP MF_00315
Gene names
Name:dxs HAMAP MF_00315
Ordered Locus Names:Acry_1833
OrganismAcidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]
Taxonomic identifier349163 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium

Protein attributes

Sequence length647 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315 SAAS SAAS001017

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315 SAAS SAAS001017

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP MF_00315 SAAS SAAS001017

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315 SAAS SAAS001017

Subunit structure

Homodimer By similarity. HAMAP MF_00315 SAAS SAAS001017

Sequence similarities

Belongs to the transketolase family. DXPS subfamily. HAMAP MF_00315

Sequences

Sequence LengthMass (Da)Tools
A5FZK3 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 35D59C59114FBEBB

FASTA64768,961
        10         20         30         40         50         60 
MPPQTPLLDR VRVPSDLRNF SADQLRQLAG ELRAETIDTV SVTGGHLGAS LGVVELTVAL 

        70         80         90        100        110        120 
HAVFETPRDR LIWDVGHQTY PHKILTGRRD RIRTLRQPGG LSGFTRRSES EYDPFGAAHS 

       130        140        150        160        170        180 
STSISAGLGM AVARDLKDES PKRHVIAVIG DGAMSAGMAY EAMNNAGASK SRMIVILNDN 

       190        200        210        220        230        240 
DMSIAPPVGA MSAYLSRLIS SRSFLSIRDF AARMAKRFPR TLERTAKRAE EYARGILTGG 

       250        260        270        280        290        300 
TLFEELGFYY VGPIDGHNLD HLLPVLRNLR DIDGDEPILL HVVTQKGKGY APAEASADKY 

       310        320        330        340        350        360 
HGVSKFNVVT GEQTKAPPGP PSYTKVFAQA LIAEAEHNPN VVAVTAAMPS GTGLDAFAKR 

       370        380        390        400        410        420 
FPDRCFDVGI AEQHAVTFAA GMATEGMAPF CAIYSTFLQR AYDQVVHDVA IQSLPVRFAM 

       430        440        450        460        470        480 
DRAGLVGADG ATHAGAYDLA YLGCLPGMVI MAPSDEAELM NCVATAAAID DRPSAFRYPR 

       490        500        510        520        530        540 
GEGTGVQLPA RGTPWEIGKG RIVREGSKVA VLALGPRLAE ALKAADELAA RGFPATVADA 

       550        560        570        580        590        600 
RFMKPLDTAL VDQLARHHEV LITIEDGSSG GFGAAVGHHL AWSGAFDSGL RFRPMTLPDR 

       610        620        630        640 
FIDHNSPAGQ LIDAGLTAKD IVAHALGALG RGAVPENSHG SVAIPAR

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References

[1]"Complete sequence of chromosome of Acidiphilium cryptum JF-5."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JF-5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000697 Genomic DNA. Translation: ABQ31035.1.
RefSeqYP_001234954.1. NC_009484.1.

3D structure databases

ProteinModelPortalA5FZK3.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5FZK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5160112.
GenomeReviewsGene locus Acry_1833 in contig CP000697_GR.
KEGGacr:Acry_1833.
PATRIC20648708. VBIAciCry6074_2327.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1154.
HOGENOMHBG571647.
OMAEAMNAHA.
ProtClustDBPRK05444.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR001017. DH_E1.
IPR005477. Dxylulose-5-P_synthase.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5FZK3_ACICJ
AccessionPrimary (citable) accession number: A5FZK3
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info