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A5FZ89

- A5FZ89_ACICJ

UniProt

A5FZ89 - A5FZ89_ACICJ

Protein

Aspartate-semialdehyde dehydrogenase

Gene

asd

Organism
Acidiphilium cryptum (strain JF-5)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.UniRule annotation

    Catalytic activityi

    L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei100 – 1001PhosphateUniRule annotation
    Active sitei135 – 1351Acyl-thioester intermediateUniRule annotation
    Binding sitei162 – 1621SubstrateUniRule annotation
    Binding sitei216 – 2161SubstrateUniRule annotation
    Binding sitei219 – 2191PhosphateUniRule annotation
    Binding sitei240 – 2401SubstrateUniRule annotation
    Active sitei247 – 2471Proton acceptorUniRule annotation
    Binding sitei320 – 3201NADPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 144NADPUniRule annotation
    Nucleotide bindingi39 – 402NADPUniRule annotation
    Nucleotide bindingi165 – 1662NADPUniRule annotation

    GO - Molecular functioni

    1. aspartate-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. N-acetyl-gamma-glutamyl-phosphate reductase activity Source: InterPro
    3. NAD binding Source: InterPro
    4. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' L-methionine biosynthetic process Source: UniProtKB-HAMAP
    2. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    3. isoleucine biosynthetic process Source: InterPro
    4. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
    5. threonine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation

    Keywords - Ligandi

    NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciACRY349163:GHET-1743-MONOMER.
    UniPathwayiUPA00034; UER00016.
    UPA00050; UER00463.
    UPA00051; UER00464.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.11UniRule annotation)
    Short name:
    ASA dehydrogenaseUniRule annotation
    Short name:
    ASADHUniRule annotation
    Alternative name(s):
    Aspartate-beta-semialdehyde dehydrogenaseUniRule annotation
    Gene namesi
    Name:asdUniRule annotation
    Ordered Locus Names:Acry_1717Imported
    OrganismiAcidiphilium cryptum (strain JF-5)Imported
    Taxonomic identifieri349163 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
    ProteomesiUP000000245: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi349163.Acry_1717.

    Structurei

    3D structure databases

    ProteinModelPortaliA5FZ89.
    SMRiA5FZ89. Positions 2-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aspartate-semialdehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0136.
    HOGENOMiHOG000013357.
    KOiK00133.
    OMAiNDPKKFP.
    OrthoDBiEOG6JB158.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_02121. ASADH.
    InterProiIPR012080. Asp_semialdehyde_DH.
    IPR005986. Asp_semialdehyde_DH_beta.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    IPR012280. Semialdhyde_DH_dimer_dom.
    [Graphical view]
    PfamiPF01118. Semialdhyde_dh. 1 hit.
    PF02774. Semialdhyde_dhC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000148. ASA_dh. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01296. asd_B. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5FZ89-1 [UniParc]FASTAAdd to Basket

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    MAYKVAVVGA TGAVGREMLK TLAERNFPAS EVIALASPRS AGQQVSFGDE    50
    AILTVKNLET FDFRGVDFGL FSPGASISAV HAPRAAEAGC IVIDNTSHFR 100
    MEPDVPLVVP EVNTHALEAF MAKPDWRRII ANPNCSTIQM VVALKPLHEK 150
    FGIRRVSVAT YQSVSGAGKE GMDELERATK ATYVHETTKP EVFTKPIAFN 200
    VIPHIDVFMK DGATKEEWKM TVETRKILDP DIAVFATCVR VPVFIGHGEA 250
    VHVEFANPAP LEAARAALRA APGVTLFDER EDGGYVTPLE CQGEDAVYVS 300
    RLRVDPTVPH GLGFWCVSDN LRKGAALNAV QIAETIVKRG LIGKKAA 347
    Length:347
    Mass (Da):37,519
    Last modified:June 12, 2007 - v1
    Checksum:iF85F82E6690F6117
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000697 Genomic DNA. Translation: ABQ30921.1.
    RefSeqiYP_001234840.1. NC_009484.1.

    Genome annotation databases

    EnsemblBacteriaiABQ30921; ABQ30921; Acry_1717.
    GeneIDi5161283.
    KEGGiacr:Acry_1717.
    PATRICi20648472. VBIAciCry6074_2217.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000697 Genomic DNA. Translation: ABQ30921.1 .
    RefSeqi YP_001234840.1. NC_009484.1.

    3D structure databases

    ProteinModelPortali A5FZ89.
    SMRi A5FZ89. Positions 2-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349163.Acry_1717.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ30921 ; ABQ30921 ; Acry_1717 .
    GeneIDi 5161283.
    KEGGi acr:Acry_1717.
    PATRICi 20648472. VBIAciCry6074_2217.

    Phylogenomic databases

    eggNOGi COG0136.
    HOGENOMi HOG000013357.
    KOi K00133.
    OMAi NDPKKFP.
    OrthoDBi EOG6JB158.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00016 .
    UPA00050 ; UER00463 .
    UPA00051 ; UER00464 .
    BioCyci ACRY349163:GHET-1743-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_02121. ASADH.
    InterProi IPR012080. Asp_semialdehyde_DH.
    IPR005986. Asp_semialdehyde_DH_beta.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    IPR012280. Semialdhyde_DH_dimer_dom.
    [Graphical view ]
    Pfami PF01118. Semialdhyde_dh. 1 hit.
    PF02774. Semialdhyde_dhC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000148. ASA_dh. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01296. asd_B. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JF-5Imported.

    Entry informationi

    Entry nameiA5FZ89_ACICJ
    AccessioniPrimary (citable) accession number: A5FZ89
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 12, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3