A5FZ25 (KHSE_ACICJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Acry_1652

Organism

Acidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]

Taxonomic identifier

349163 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Homoserine kinase HAMAP MF_00301		PRO_1000022574

Sequences

	Sequence		Length	Mass (Da)
	A5FZ25 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 54A2F8B8A4B0F12F	FASTA	319	34,972
	10 20 30 40 50 60 MAVYTEVTDD ALAAFLEGYD IGRMVAFRGI AEGVENSNYS LRTTEGDFIL TLYERRVDPA 70 80 90 100 110 120 DLPWFLGLME HLAAKSLPCP LPVRARDGAN LNPLAGRIAA ITTFLPGVWP RRPTVAHCGP 130 140 150 160 170 180 LGAAMARMHL AGEDYAPTRA NALGPQGWPP LLARCGDSGD AVRPGLTGEV RTALDATLAA 190 200 210 220 230 240 WPGALPRGHI HADLFPDNVF FLDHAISGLI DFYFAATDLY AYDIAVCLNA WCFEPDFSFN 250 260 270 280 290 300 ITKSRALLRG YQAVRPLSAA ETEALPVLCR GAAIRFLLTR LYDWINTPDD ALVTRKDPLD 310 YYWRLRFHLQ AGSAADYGV

References

[1]

"Complete sequence of chromosome of Acidiphilium cryptum JF-5." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JF-5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000697 Genomic DNA. Translation: ABQ30857.1.
RefSeq	YP_001234776.1. NC_009484.1.
3D structure databases
ProteinModelPortal	A5FZ25.
SMR	A5FZ25. Positions 5-319.
ModBase	Search...
Protein-protein interaction databases
STRING	A5FZ25.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5160934.
GenomeReviews	Gene locus Acry_1652 in contig CP000697_GR.
KEGG	acr:Acry_1652.
PATRIC	20648334. VBIAciCry6074_2151.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2334.
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	ACRY349163:ACRY_1652-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_ACICJ

Accession

Primary (citable) accession number: A5FZ25

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 12, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program