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A5FYN4 (MURA_ACICJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase

EC=2.5.1.7
Alternative name(s):
Enoylpyruvate transferase
UDP-N-acetylglucosamine enolpyruvyl transferase
Short name=EPT
Gene names
Name:murA
Ordered Locus Names:Acry_1508
OrganismAcidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]
Taxonomic identifier349163 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00111.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418UDP-N-acetylglucosamine 1-carboxyvinyltransferase HAMAP-Rule MF_00111
PRO_1000023012

Sites

Active site1161Proton donor By similarity

Amino acid modifications

Modified residue11612-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

Sequence LengthMass (Da)Tools
A5FYN4 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: BA948EE40865629D

FASTA41843,643
        10         20         30         40         50         60 
MDRIRIRGGR PLEGVIDISG AKNSALKVMV AGLLTDERLE LENVPALADV ATMAQLLAQH 

        70         80         90        100        110        120 
GIAVEETGAK QLSVGGAITN TEAPYDIVRK MRASILVLGP LLARTGEARV SLPGGCAIGT 

       130        140        150        160        170        180 
RPVDLHLKGL EAMGAEIALD GGYINARAPK GLHGATITFP FVSVGATEQL LLTATLAEGE 

       190        200        210        220        230        240 
TVLVNAAREP EIGDLADCLN KMGADISGIG SDRLTIRGVK ALHGARHTIL PDRIEAGTYA 

       250        260        270        280        290        300 
CAAAITGGGV LLRGARMFDL GALASTLGEA GVDVTEVAEG VTVSRRNGLH GTDAMTEPFP 

       310        320        330        340        350        360 
GFVTDMQAQF MTLMAVAEGA SMITETIFEN RFMHVPELNR MGARINVHGS SAIVRGVPGL 

       370        380        390        400        410 
SGAPVMATDL RASFSLVLAG LAAKGETIVN RVYHLDRGYE AVERKLAACG ADIERLRD 

« Hide

References

[1]"Complete sequence of chromosome of Acidiphilium cryptum JF-5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JF-5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000697 Genomic DNA. Translation: ABQ30716.1.
RefSeqYP_001234635.1. NC_009484.1.

3D structure databases

ProteinModelPortalA5FYN4.
SMRA5FYN4. Positions 1-417.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349163.Acry_1508.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ30716; ABQ30716; Acry_1508.
GeneID5160297.
KEGGacr:Acry_1508.
PATRIC20648034. VBIAciCry6074_2003.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0766.
HOGENOMHOG000075602.
KOK00790.
OMAHGLEQMG.
OrthoDBEOG68M4GK.

Enzyme and pathway databases

BioCycACRY349163:GHET-1529-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00111. MurA.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. SSF55205. 1 hit.
TIGRFAMsTIGR01072. murA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURA_ACICJ
AccessionPrimary (citable) accession number: A5FYN4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways