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Protein

ATP-dependent protease ATPase subunit HslU

Gene

hslU

Organism
Acidiphilium cryptum (strain JF-5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei250ATPUniRule annotation1
Binding sitei317ATPUniRule annotation1
Binding sitei389ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 68ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotationSAAS annotation
Biological processStress responseImported
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent protease ATPase subunit HslUUniRule annotationSAAS annotation
Alternative name(s):
Unfoldase HslUUniRule annotation
Gene namesi
Name:hslUUniRule annotation
Ordered Locus Names:Acry_1409Imported
OrganismiAcidiphilium cryptum (strain JF-5)Imported
Taxonomic identifieri349163 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
Proteomesi
  • UP000000245 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi349163.Acry_1409.

Structurei

3D structure databases

ProteinModelPortaliA5FYD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 328AAAInterPro annotationAdd BLAST277
Domaini331 – 427ClpB_D2-smallInterPro annotationAdd BLAST97

Sequence similaritiesi

Belongs to the ClpX chaperone family. HslU subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C4N. Bacteria.
COG1220. LUCA.
HOGENOMiHOG000010036.
KOiK03667.
OMAiKYGMIKT.
OrthoDBiPOG091H01U4.

Family and domain databases

HAMAPiMF_00249. HslU. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004491. HslU.
IPR027417. P-loop_NTPase.
PANTHERiPTHR43815. PTHR43815. 1 hit.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00390. hslU. 1 hit.

Sequencei

Sequence statusi: Complete.

A5FYD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDSPTYTPR EIVSELDRFI VGQQDAKRAV AIALRNRWRR QQLPEGLREE
60 70 80 90 100
VVPKNILMIG PTGCGKTEIA RRLAKLAQAP FIKVEATKFT EVGYVGRDVE
110 120 130 140 150
SIVRDLVEVS ITMLRDMSRK GVQARAELAA EDRLLTALVG EGASSETRNR
160 170 180 190 200
FRRMLRDGEM EEKEIDVDVS EAPPNVIGQM DMPGMPPGGA INLGDMMKSM
210 220 230 240 250
FGRQHGRKRM TVAAARAALE REEADRLLDN EQLTADARLH AETHGIVFLD
260 270 280 290 300
EIDKICARTE SGFRGGDVSR EGVQRDLLPL IEGTTVSTKY GPVKTDHILF
310 320 330 340 350
IASGAFHVAK PSDLLPELQG RLPIRVELAS LSREDFRRIL TEPEHSLLKQ
360 370 380 390 400
YVALMKTENV DLHFTDDAVD AVAALAADIN DRVENIGARR LATVLERLLE
410 420 430
EISFAATDRA GETVTVDAAL VNDKVAPLAA RGDLGRFIL
Length:439
Mass (Da):48,535
Last modified:June 12, 2007 - v1
Checksum:i6C43CD08A51E6E9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000697 Genomic DNA. Translation: ABQ30619.1.

Genome annotation databases

EnsemblBacteriaiABQ30619; ABQ30619; Acry_1409.
KEGGiacr:Acry_1409.

Similar proteinsi

Entry informationi

Entry nameiA5FYD7_ACICJ
AccessioniPrimary (citable) accession number: A5FYD7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: June 7, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported