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A5FY49 (AROC_ACICJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:Acry_1320
OrganismAcidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]
Taxonomic identifier349163 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Chorismate synthase HAMAP MF_00300
PRO_0000322378

Sequences

Sequence LengthMass (Da)Tools
A5FY49 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: BEEAB89A2CD5C0AE

FASTA36939,455
        10         20         30         40         50         60 
MSYNSFGHLF RVTTWGESHG PAIGCVVDGV PPRIPLSEAD IQPFLDRRRP GQSRFTTQRR 

        70         80         90        100        110        120 
EPDIVRILSG VHGGVTTGTP VALQIENTDQ RSQDYANIAD RFRPGHADIA YHWKYGVRDP 

       130        140        150        160        170        180 
RGGGRSSARE TATRVAAGAI ARKILGERVR IRGALVQMGR HAIDRARFDW DEVDRNAFFC 

       190        200        210        220        230        240 
PDPEAAKAWA EELDAVRKAG SSLGAVVEVV AEGISPGLGA PVYAKLDADL AAAMMSINAV 

       250        260        270        280        290        300 
KGVEIGDGFA AAALRGEENA DEMRMNEDGT VRFLANHAGG VLGGISTGQP VIVRFAVKPT 

       310        320        330        340        350        360 
SSILTPVHSV DSDGDEVDIQ TKGRHDPCVG IRAVPVGEAM MACVLADQLL LHRAQCGETG 


AGRLPLAKK

« Hide

References

[1]"Complete sequence of chromosome of Acidiphilium cryptum JF-5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JF-5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000697 Genomic DNA. Translation: ABQ30531.1.
RefSeqYP_001234450.1. NC_009484.1.

3D structure databases

ProteinModelPortalA5FY49.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5FY49.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5159565.
GenomeReviewsGene locus Acry_1320 in contig CP000697_GR.
KEGGacr:Acry_1320.
PATRIC20647654. VBIAciCry6074_1815.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0082.
HOGENOMHBG292336.
OMASRFTTQR.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycACRY349163:ACRY_1320-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_ACICJ
AccessionPrimary (citable) accession number: A5FY49
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 12, 2007
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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