Reviewed, UniProtKB/Swiss-Prot A5FWQ8 (F16PA_ACICJ)

Names and origin

Protein names

Recommended name:
    Fructose-1,6-bisphosphatase class 1
      Short name=FBPase class 1
    EC=3.1.3.11
Alternative name(s):
    D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Gene names

Name:	fbp
Ordered Locus Names:	Acry_0821

Organism

Acidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]

Taxonomic identifier

349163 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the FBPase class 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 355	355	Fructose-1,6-bisphosphatase class 1 HAMAP MF_01855		PRO_0000364443
Regions
	Region	112 – 115	4	Substrate binding By similarity
	Region	256 – 258	3	Substrate binding By similarity
Sites
	Metal binding	90	1	Magnesium 1 By similarity
	Metal binding	109	1	Magnesium 1 By similarity
	Metal binding	109	1	Magnesium 2 By similarity
	Metal binding	111	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	112	1	Magnesium 2 By similarity
	Metal binding	276	1	Magnesium 2 By similarity
	Binding site	204	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5FWQ8-1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 20B4591F918C72DF	FASTA	355	37,722
	10 20 30 40 50 60 MSDALRLDTC LDQIASQLPA LTASCRVVEA LAGAARQIAH LLARGPLSGD LGAVIGESLD 70 80 90 100 110 120 GDGQKALDAI THALVREAVI ASGAAAFASE EAAAPEWLDP VGEVAVAVDP LDGSSNIDTL 130 140 150 160 170 180 APVGTIFSIL PARHASGADP ASPFLQTGRR QLAAGFFIYG PRTALAVTFG NGTRIFTLDP 190 200 210 220 230 240 VSGAFLAPAP PATVPAATRE YAINGSNLRH WEEPIRDYIV ELKQGRNGPR GIDFNTRWLA 250 260 270 280 290 300 SMVGDAFRIL GRGGIYLYPA DERQGYEAGR LRLVYEANPI AFLMEQAGAS ATDGRIPILD 310 320 330 340 350 LQPAHIHQRC PLVFGSADEV RRVAQAYERA GQPSSPLFRR RSLFRSTSNV AELFA

References

[1]

"Complete sequence of chromosome of Acidiphilium cryptum JF-5." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000697 Genomic DNA. Translation: ABQ30040.1.
RefSeq	YP_001233959.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A5FWQ8.
Genome annotation databases
GeneID	5161624.
GenomeReviews	Gene locus Acry_0821 in contig CP000697_GR.
KEGG	acr:Acry_0821.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	LFGQRGL.
Family and domain databases
HAMAP	MF_01855. [Tree]
InterPro	IPR000146. Fructose_bisphosphatase. IPR020548. Fructose_bisphosphatase_AS. [Graphical view]
PANTHER	PTHR11556. In_FB_phphtase. 1 hit.
Pfam	PF00316. FBPase. 1 hit. [Graphical view]
PRINTS	PR00115. F16BPHPHTASE.
ProDom	PD001491. In_FB_phphtase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00124. FBPASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F16PA_ACICJ

Accession

Primary (citable) accession number: A5FWQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	June 12, 2007
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)