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Protein

Fructose-1,6-bisphosphatase class 1

Gene

fbp

Organism
Acidiphilium cryptum (strain JF-5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90Magnesium 1UniRule annotation1
Metal bindingi109Magnesium 1UniRule annotation1
Metal bindingi109Magnesium 2UniRule annotation1
Metal bindingi111Magnesium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi112Magnesium 2UniRule annotation1
Binding sitei204SubstrateUniRule annotation1
Metal bindingi276Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphatase class 1UniRule annotation (EC:3.1.3.11UniRule annotation)
Short name:
FBPase class 1UniRule annotation
Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1UniRule annotation
Gene namesi
Name:fbpUniRule annotation
Ordered Locus Names:Acry_0821
OrganismiAcidiphilium cryptum (strain JF-5)
Taxonomic identifieri349163 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
Proteomesi
  • UP000000245 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003644431 – 355Fructose-1,6-bisphosphatase class 1Add BLAST355

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi349163.Acry_0821.

Structurei

3D structure databases

ProteinModelPortaliA5FWQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni112 – 115Substrate bindingUniRule annotation4
Regioni256 – 258Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the FBPase class 1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZI. Bacteria.
COG0158. LUCA.
HOGENOMiHOG000191264.
KOiK03841.
OMAiTLDRTDN.
OrthoDBiPOG091H05DB.

Family and domain databases

CDDicd00354. FBPase. 1 hit.
HAMAPiMF_01855. FBPase_class1. 1 hit.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.
PROSITEiPS00124. FBPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5FWQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDALRLDTC LDQIASQLPA LTASCRVVEA LAGAARQIAH LLARGPLSGD
60 70 80 90 100
LGAVIGESLD GDGQKALDAI THALVREAVI ASGAAAFASE EAAAPEWLDP
110 120 130 140 150
VGEVAVAVDP LDGSSNIDTL APVGTIFSIL PARHASGADP ASPFLQTGRR
160 170 180 190 200
QLAAGFFIYG PRTALAVTFG NGTRIFTLDP VSGAFLAPAP PATVPAATRE
210 220 230 240 250
YAINGSNLRH WEEPIRDYIV ELKQGRNGPR GIDFNTRWLA SMVGDAFRIL
260 270 280 290 300
GRGGIYLYPA DERQGYEAGR LRLVYEANPI AFLMEQAGAS ATDGRIPILD
310 320 330 340 350
LQPAHIHQRC PLVFGSADEV RRVAQAYERA GQPSSPLFRR RSLFRSTSNV

AELFA
Length:355
Mass (Da):37,722
Last modified:June 12, 2007 - v1
Checksum:i20B4591F918C72DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000697 Genomic DNA. Translation: ABQ30040.1.
RefSeqiWP_011941805.1. NC_009484.1.

Genome annotation databases

EnsemblBacteriaiABQ30040; ABQ30040; Acry_0821.
KEGGiacr:Acry_0821.
PATRICi20646624. VBIAciCry6074_1309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000697 Genomic DNA. Translation: ABQ30040.1.
RefSeqiWP_011941805.1. NC_009484.1.

3D structure databases

ProteinModelPortaliA5FWQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349163.Acry_0821.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ30040; ABQ30040; Acry_0821.
KEGGiacr:Acry_0821.
PATRICi20646624. VBIAciCry6074_1309.

Phylogenomic databases

eggNOGiENOG4105CZI. Bacteria.
COG0158. LUCA.
HOGENOMiHOG000191264.
KOiK03841.
OMAiTLDRTDN.
OrthoDBiPOG091H05DB.

Enzyme and pathway databases

UniPathwayiUPA00138.

Family and domain databases

CDDicd00354. FBPase. 1 hit.
HAMAPiMF_01855. FBPase_class1. 1 hit.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.
PROSITEiPS00124. FBPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF16PA_ACICJ
AccessioniPrimary (citable) accession number: A5FWQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 12, 2007
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.