Reviewed, UniProtKB/Swiss-Prot A5FWI3 (ARLY_ACICJ)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Acry_0745

Organism

Acidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]

Taxonomic identifier

349163 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 471	471	Argininosuccinate lyase HAMAP MF_00006		PRO_0000321421

Sequences

	Sequence		Length	Mass (Da)
	A5FWI3-1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: D9B4DE3C9E3DBC27	FASTA	471	50,854
	10 20 30 40 50 60 MTNSGADQAG TQPSRLQWGG RFAAGPASVM QAINASIGFD QRLWREDIEG SLAHAGMLAA 70 80 90 100 110 120 MGIISAEDEA AIRAGLAEIA EAIAEGSFTF DPALEDIHTN IEAWLVARIG EAGRRLHTAR 130 140 150 160 170 180 SRNDQVATDF RLWVRNAIDS LDGQVRELMR ALADRAAEHA ATIMPGFTHL QTAQPVTLGH 190 200 210 220 230 240 HLLAYVEMLS RDRGRLADAR RRLNECPLGA AALAGTTFPI DRSMTAAALG FDRPTANSLD 250 260 270 280 290 300 SVSDRDFALE FLSALSILAM HLSRFAEEII IWTSAPYRFI RLSDAYTTGS SIMPQKRNPD 310 320 330 340 350 360 AAELARAKAG RIFGALTGLL AVMKGLPLAY AKDMQEDKEP VFDAADAAEL CLAAMTGMVR 370 380 390 400 410 420 DMMPDVLRMR SVAGADFSTA TDLADYLVRD LGLPFRTAHH VTGRIVSEAE SRGLELVALP 430 440 450 460 470 LSVMQEVEPR ITEAVYDVLT IEASVAARRT LGGTAPDNVA RAAARWQETL A

References

[1]

"Complete sequence of chromosome of Acidiphilium cryptum JF-5." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000697 Genomic DNA. Translation: ABQ29965.1.
RefSeq	YP_001233884.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A5FWI3.
Genome annotation databases
GeneID	5160356.
GenomeReviews	Gene locus Acry_0745 in contig CP000697_GR.
KEGG	acr:Acry_0745.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MAEDLIF.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ACICJ

Accession

Primary (citable) accession number: A5FWI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 12, 2007
Last modified:	November 3, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)