Skip Header

Contribute Send feedback
Read comments (?) or add your own

A5FWI3 (ARLY_ACICJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:Acry_0745
OrganismAcidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]
Taxonomic identifier349163 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Argininosuccinate lyase HAMAP MF_00006
PRO_0000321421

Sequences

Sequence LengthMass (Da)Tools
A5FWI3 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: D9B4DE3C9E3DBC27

FASTA47150,854
        10         20         30         40         50         60 
MTNSGADQAG TQPSRLQWGG RFAAGPASVM QAINASIGFD QRLWREDIEG SLAHAGMLAA 

        70         80         90        100        110        120 
MGIISAEDEA AIRAGLAEIA EAIAEGSFTF DPALEDIHTN IEAWLVARIG EAGRRLHTAR 

       130        140        150        160        170        180 
SRNDQVATDF RLWVRNAIDS LDGQVRELMR ALADRAAEHA ATIMPGFTHL QTAQPVTLGH 

       190        200        210        220        230        240 
HLLAYVEMLS RDRGRLADAR RRLNECPLGA AALAGTTFPI DRSMTAAALG FDRPTANSLD 

       250        260        270        280        290        300 
SVSDRDFALE FLSALSILAM HLSRFAEEII IWTSAPYRFI RLSDAYTTGS SIMPQKRNPD 

       310        320        330        340        350        360 
AAELARAKAG RIFGALTGLL AVMKGLPLAY AKDMQEDKEP VFDAADAAEL CLAAMTGMVR 

       370        380        390        400        410        420 
DMMPDVLRMR SVAGADFSTA TDLADYLVRD LGLPFRTAHH VTGRIVSEAE SRGLELVALP 

       430        440        450        460        470 
LSVMQEVEPR ITEAVYDVLT IEASVAARRT LGGTAPDNVA RAAARWQETL A

« Hide

References

[1]"Complete sequence of chromosome of Acidiphilium cryptum JF-5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JF-5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000697 Genomic DNA. Translation: ABQ29965.1.
RefSeqYP_001233884.1. NC_009484.1.

3D structure databases

ProteinModelPortalA5FWI3.
SMRA5FWI3. Positions 26-471.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5FWI3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5160356.
GenomeReviewsGene locus Acry_0745 in contig CP000697_GR.
KEGGacr:Acry_0745.
PATRIC20646474. VBIAciCry6074_1234.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHBG539632.
OMAMAEDLIF.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycACRY349163:ACRY_0745-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_ACICJ
AccessionPrimary (citable) accession number: A5FWI3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 12, 2007
Last modified: January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents