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A5FWH1 (PYRB_ACICJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aspartate carbamoyltransferase

EC=2.1.3.2
Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase
Gene names
Name:pyrB
Ordered Locus Names:Acry_0733
OrganismAcidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]
Taxonomic identifier349163 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP-Rule MF_00001

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP-Rule MF_00001

Sequence similarities

Belongs to the ATCase/OTCase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Aspartate carbamoyltransferase HAMAP-Rule MF_00001
PRO_0000321059

Sequences

Sequence LengthMass (Da)Tools
A5FWH1 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 16FFB92DF2154AE2

FASTA31133,475
        10         20         30         40         50         60 
MRLPTRHLLG IEGLHPRDIS ALLDLAESYV LLNRSGKTRR DVLRGRTLIN LFFEDSTRTR 

        70         80         90        100        110        120 
TSFELAGKRL GADVINMSVS TSSVSKGETL LDTAATLNAM NCDLLVVRHK ASGAPALLAQ 

       130        140        150        160        170        180 
KVDAAVINAG DGMHEHPTQA LLDALTIRRN KGTLAGLTVA ICGDIAHSRV ARSNLLLLTA 

       190        200        210        220        230        240 
MGSRVRVVGP PTLIPSGIDQ FGATVFHDMR EGLRDADIVM ALRLQTERMS AGLIPSAREF 

       250        260        270        280        290        300 
FTFYGLDAAK LAMAKPDALV MHPGPMNRGV EIDSQVADDA TRSVIREQVE MGVAIRMAVL 

       310 
DVLARTALAH A 

« Hide

References

[1]"Complete sequence of chromosome of Acidiphilium cryptum JF-5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JF-5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000697 Genomic DNA. Translation: ABQ29953.1.
RefSeqYP_001233872.1. NC_009484.1.

3D structure databases

ProteinModelPortalA5FWH1.
ModBaseSearch...

Protein-protein interaction databases

STRING349163.Acry_0733.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ29953; ABQ29953; Acry_0733.
GeneID5162211.
KEGGacr:Acry_0733.
PATRIC20646444. VBIAciCry6074_1221.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0540.
HOGENOMHOG000022685.
KOK00609.
OMAMTLNAMR.
ProtClustDBPRK00856.

Enzyme and pathway databases

BioCycACRY349163:GHET-788-MONOMER.
UniPathwayUPA00070; UER00116.

Family and domain databases

HAMAPMF_00001. Asp_carb_tr.
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00670. asp_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRB_ACICJ
AccessionPrimary (citable) accession number: A5FWH1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 12, 2007
Last modified: May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families