A5FWH1 (PYRB_ACICJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Acry_0733

Organism

Acidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]

Taxonomic identifier

349163 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium › Acidiphilium cryptum

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP-Rule MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP-Rule MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' UMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway 'de novo' pyrimidine nucleobase biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Aspartate carbamoyltransferase HAMAP-Rule MF_00001		PRO_0000321059

Sequences

	Sequence		Length	Mass (Da)
	A5FWH1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 16FFB92DF2154AE2	FASTA	311	33,475
	10 20 30 40 50 60 MRLPTRHLLG IEGLHPRDIS ALLDLAESYV LLNRSGKTRR DVLRGRTLIN LFFEDSTRTR 70 80 90 100 110 120 TSFELAGKRL GADVINMSVS TSSVSKGETL LDTAATLNAM NCDLLVVRHK ASGAPALLAQ 130 140 150 160 170 180 KVDAAVINAG DGMHEHPTQA LLDALTIRRN KGTLAGLTVA ICGDIAHSRV ARSNLLLLTA 190 200 210 220 230 240 MGSRVRVVGP PTLIPSGIDQ FGATVFHDMR EGLRDADIVM ALRLQTERMS AGLIPSAREF 250 260 270 280 290 300 FTFYGLDAAK LAMAKPDALV MHPGPMNRGV EIDSQVADDA TRSVIREQVE MGVAIRMAVL 310 DVLARTALAH A

References

[1]

"Complete sequence of chromosome of Acidiphilium cryptum JF-5." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JF-5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000697 Genomic DNA. Translation: ABQ29953.1.
RefSeq	YP_001233872.1. NC_009484.1.
3D structure databases
ProteinModelPortal	A5FWH1.
ModBase	Search...
Protein-protein interaction databases
STRING	349163.Acry_0733.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABQ29953; ABQ29953; Acry_0733.
GeneID	5162211.
KEGG	acr:Acry_0733.
PATRIC	20646444. VBIAciCry6074_1221.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HOG000022685.
KO	K00609.
OMA	MTLNAMR.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	ACRY349163:GHET-788-MONOMER.
UniPathway	UPA00070; UER00116.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr.
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR002082. Asp_carbamoyltransf. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_ACICJ

Accession

Primary (citable) accession number: A5FWH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 12, 2007
Last modified:	May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program