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A5FWG2

- UPPP_ACICJ

UniProt

A5FWG2 - UPPP_ACICJ

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, Acry_0723
Organism
Acidiphilium cryptum (strain JF-5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciACRY349163:GHET-733-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:Acry_0723
OrganismiAcidiphilium cryptum (strain JF-5)
Taxonomic identifieri349163 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
ProteomesiUP000000245: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2923Helical; Reviewed prediction
Add
BLAST
Transmembranei45 – 6521Helical; Reviewed prediction
Add
BLAST
Transmembranei89 – 10921Helical; Reviewed prediction
Add
BLAST
Transmembranei115 – 13521Helical; Reviewed prediction
Add
BLAST
Transmembranei153 – 17321Helical; Reviewed prediction
Add
BLAST
Transmembranei196 – 21621Helical; Reviewed prediction
Add
BLAST
Transmembranei229 – 24921Helical; Reviewed prediction
Add
BLAST
Transmembranei258 – 27821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Undecaprenyl-diphosphataseUniRule annotation
PRO_1000062783Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349163.Acry_0723.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiNANEAVD.
OrthoDBiEOG6PW24M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5FWG2-1 [UniParc]FASTAAdd to Basket

« Hide

MTPLIAVLFA ILQGATELFP VSSLGHVVIV PALLHWPIDQ ASPSFLPFVV    50
MLHVGTATAL LLYFWREWWA MLAGLLGRGE PGEVDAQRGL LLRLVVATLP 100
AVLIGFALKK PIQHLFASPE IAAAFLIANG AVLIIGERLR RRRAGNGFGI 150
GQLTLRDSLV IGLFQCLAFL PGLSRSGSAI VGGLTRGLDH EAAARFAFLM 200
ATPVIAGAAV IEVPHLLHHA AAARGMFGTA LLAAVVAGVV AYLSTAFLMR 250
YFRNHDRWAL GPFAAYCALF GALSLILIPF GA 282
Length:282
Mass (Da):29,973
Last modified:June 12, 2007 - v1
Checksum:i2707F02352412899
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000697 Genomic DNA. Translation: ABQ29944.1.
RefSeqiWP_011941726.1. NC_009484.1.
YP_001233863.1. NC_009484.1.

Genome annotation databases

EnsemblBacteriaiABQ29944; ABQ29944; Acry_0723.
GeneIDi5161175.
KEGGiacr:Acry_0723.
PATRICi20646424. VBIAciCry6074_1211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000697 Genomic DNA. Translation: ABQ29944.1 .
RefSeqi WP_011941726.1. NC_009484.1.
YP_001233863.1. NC_009484.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349163.Acry_0723.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ29944 ; ABQ29944 ; Acry_0723 .
GeneIDi 5161175.
KEGGi acr:Acry_0723.
PATRICi 20646424. VBIAciCry6074_1211.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi NANEAVD.
OrthoDBi EOG6PW24M.

Enzyme and pathway databases

BioCyci ACRY349163:GHET-733-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JF-5.

Entry informationi

Entry nameiUPPP_ACICJ
AccessioniPrimary (citable) accession number: A5FWG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi