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A5FWG2 (UPPP_ACICJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Acry_0723
OrganismAcidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]
Taxonomic identifier349163 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000062783

Regions

Transmembrane7 – 2923Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane153 – 17321Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane258 – 27821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A5FWG2 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 2707F02352412899

FASTA28229,973
        10         20         30         40         50         60 
MTPLIAVLFA ILQGATELFP VSSLGHVVIV PALLHWPIDQ ASPSFLPFVV MLHVGTATAL 

        70         80         90        100        110        120 
LLYFWREWWA MLAGLLGRGE PGEVDAQRGL LLRLVVATLP AVLIGFALKK PIQHLFASPE 

       130        140        150        160        170        180 
IAAAFLIANG AVLIIGERLR RRRAGNGFGI GQLTLRDSLV IGLFQCLAFL PGLSRSGSAI 

       190        200        210        220        230        240 
VGGLTRGLDH EAAARFAFLM ATPVIAGAAV IEVPHLLHHA AAARGMFGTA LLAAVVAGVV 

       250        260        270        280 
AYLSTAFLMR YFRNHDRWAL GPFAAYCALF GALSLILIPF GA 

« Hide

References

[1]"Complete sequence of chromosome of Acidiphilium cryptum JF-5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JF-5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000697 Genomic DNA. Translation: ABQ29944.1.
RefSeqYP_001233863.1. NC_009484.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349163.Acry_0723.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ29944; ABQ29944; Acry_0723.
GeneID5161175.
KEGGacr:Acry_0723.
PATRIC20646424. VBIAciCry6074_1211.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMANANEAVD.
OrthoDBEOG6PW24M.

Enzyme and pathway databases

BioCycACRY349163:GHET-733-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_ACICJ
AccessionPrimary (citable) accession number: A5FWG2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families