Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A5FUM6 (PQQC_ACICJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyrroloquinoline-quinone synthase

EC=1.3.3.11
Alternative name(s):
Coenzyme PQQ synthesis protein C
Pyrroloquinoline quinone biosynthesis protein C
Gene names
Name:pqqC
Ordered Locus Names:Acry_0079
OrganismAcidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]
Taxonomic identifier349163 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity. HAMAP-Rule MF_00654

Catalytic activity

6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O. HAMAP-Rule MF_00654

Pathway

Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. HAMAP-Rule MF_00654

Sequence similarities

Belongs to the PqqC family.

Ontologies

Keywords
   Biological processPQQ biosynthesis
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpyrroloquinoline quinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionpyrroloquinoline-quinone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Pyrroloquinoline-quinone synthase HAMAP-Rule MF_00654
PRO_1000061666

Sequences

Sequence LengthMass (Da)Tools
A5FUM6 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 06241FA6803AA75D

FASTA24627,693
        10         20         30         40         50         60 
MTVLMSPDEL EAALRAVGAA RYHNRHPFHQ LLHGGKLDKR QVQAWALNRY CYQAAIPIKD 

        70         80         90        100        110        120 
ATLIARTDDS ELRRIWRQRL VDHDGTQPGE GGIVRWLALA EGLGLDRDMV ISERRALPAT 

       130        140        150        160        170        180 
RFAVRAYVDF VRDRSLLEAV ASSLTEMFSP TIISERVSGM LANYDFITRE TLAYFNARLD 

       190        200        210        220        230        240 
QAPRDADFAL DYVKRHARTP EQQQAAIAAL TFKCDVLWAQ LDALHHAYVS PGLIPPGAFG 


HDGIWS 

« Hide

References

[1]"Complete sequence of chromosome of Acidiphilium cryptum JF-5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JF-5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000697 Genomic DNA. Translation: ABQ29308.1.
RefSeqYP_001233227.1. NC_009484.1.

3D structure databases

ProteinModelPortalA5FUM6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349163.Acry_0079.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ29308; ABQ29308; Acry_0079.
GeneID5162239.
KEGGacr:Acry_0079.
PATRIC20645098. VBIAciCry6074_0556.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG5424.
HOGENOMHOG000217947.
KOK06137.
OMARYHNLHR.
OrthoDBEOG6JTC7S.

Enzyme and pathway databases

BioCycACRY349163:GHET-81-MONOMER.
UniPathwayUPA00539.

Family and domain databases

Gene3D1.20.910.10. 1 hit.
HAMAPMF_00654. PQQ_syn_PqqC.
InterProIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMSSF48613. SSF48613. 1 hit.
TIGRFAMsTIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNetSearch...

Entry information

Entry namePQQC_ACICJ
AccessionPrimary (citable) accession number: A5FUM6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways