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A5FUM6

- PQQC_ACICJ

UniProt

A5FUM6 - PQQC_ACICJ

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Protein

Pyrroloquinoline-quinone synthase

Gene

pqqC

Organism
Acidiphilium cryptum (strain JF-5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.UniRule annotation

Catalytic activityi

6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. pyrroloquinoline-quinone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyrroloquinoline quinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

PQQ biosynthesis

Enzyme and pathway databases

BioCyciACRY349163:GHET-81-MONOMER.
UniPathwayiUPA00539.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrroloquinoline-quinone synthaseUniRule annotation (EC:1.3.3.11UniRule annotation)
Alternative name(s):
Coenzyme PQQ synthesis protein CUniRule annotation
Pyrroloquinoline quinone biosynthesis protein CUniRule annotation
Gene namesi
Name:pqqCUniRule annotation
Ordered Locus Names:Acry_0079
OrganismiAcidiphilium cryptum (strain JF-5)
Taxonomic identifieri349163 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeAcidiphilium
ProteomesiUP000000245: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Pyrroloquinoline-quinone synthasePRO_1000061666Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349163.Acry_0079.

Structurei

3D structure databases

ProteinModelPortaliA5FUM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PqqC family.UniRule annotation

Phylogenomic databases

eggNOGiCOG5424.
HOGENOMiHOG000217947.
KOiK06137.
OMAiRYHNLHR.
OrthoDBiEOG6JTC7S.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
HAMAPiMF_00654. PQQ_syn_PqqC.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR02111. PQQ_syn_pqqC. 1 hit.

Sequencei

Sequence statusi: Complete.

A5FUM6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVLMSPDEL EAALRAVGAA RYHNRHPFHQ LLHGGKLDKR QVQAWALNRY
60 70 80 90 100
CYQAAIPIKD ATLIARTDDS ELRRIWRQRL VDHDGTQPGE GGIVRWLALA
110 120 130 140 150
EGLGLDRDMV ISERRALPAT RFAVRAYVDF VRDRSLLEAV ASSLTEMFSP
160 170 180 190 200
TIISERVSGM LANYDFITRE TLAYFNARLD QAPRDADFAL DYVKRHARTP
210 220 230 240
EQQQAAIAAL TFKCDVLWAQ LDALHHAYVS PGLIPPGAFG HDGIWS
Length:246
Mass (Da):27,693
Last modified:June 12, 2007 - v1
Checksum:i06241FA6803AA75D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000697 Genomic DNA. Translation: ABQ29308.1.
RefSeqiYP_001233227.1. NC_009484.1.

Genome annotation databases

EnsemblBacteriaiABQ29308; ABQ29308; Acry_0079.
GeneIDi5162239.
KEGGiacr:Acry_0079.
PATRICi20645098. VBIAciCry6074_0556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000697 Genomic DNA. Translation: ABQ29308.1 .
RefSeqi YP_001233227.1. NC_009484.1.

3D structure databases

ProteinModelPortali A5FUM6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349163.Acry_0079.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ29308 ; ABQ29308 ; Acry_0079 .
GeneIDi 5162239.
KEGGi acr:Acry_0079.
PATRICi 20645098. VBIAciCry6074_0556.

Phylogenomic databases

eggNOGi COG5424.
HOGENOMi HOG000217947.
KOi K06137.
OMAi RYHNLHR.
OrthoDBi EOG6JTC7S.

Enzyme and pathway databases

UniPathwayi UPA00539 .
BioCyci ACRY349163:GHET-81-MONOMER.

Family and domain databases

Gene3Di 1.20.910.10. 1 hit.
HAMAPi MF_00654. PQQ_syn_PqqC.
InterProi IPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view ]
Pfami PF03070. TENA_THI-4. 1 hit.
[Graphical view ]
SUPFAMi SSF48613. SSF48613. 1 hit.
TIGRFAMsi TIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JF-5.

Entry informationi

Entry nameiPQQC_ACICJ
AccessioniPrimary (citable) accession number: A5FUM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3