Reviewed, UniProtKB/Swiss-Prot A5FUM6 (PQQC_ACICJ)

Names and origin

Protein names

Recommended name:
    Pyrroloquinoline-quinone synthase
    EC=1.3.3.11
Alternative name(s):
    Coenzyme PQQ synthesis protein C
    Pyrroloquinoline quinone biosynthesis protein C

Gene names

Name:	pqqC
Ordered Locus Names:	Acry_0079

Organism

Acidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]

Taxonomic identifier

349163 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity.
Catalytic activity	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O. HAMAP MF_00654
Pathway	Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. HAMAP MF_00654
Sequence similarities	Belongs to the pqqC family.

Ontologies

Keywords
Biological process	PQQ biosynthesis
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyrroloquinoline quinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	pyrroloquinoline-quinone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Pyrroloquinoline-quinone synthase HAMAP MF_00654		PRO_1000061666

Sequences

	Sequence		Length	Mass (Da)
	A5FUM6-1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 06241FA6803AA75D	FASTA	246	27,693
	10 20 30 40 50 60 MTVLMSPDEL EAALRAVGAA RYHNRHPFHQ LLHGGKLDKR QVQAWALNRY CYQAAIPIKD 70 80 90 100 110 120 ATLIARTDDS ELRRIWRQRL VDHDGTQPGE GGIVRWLALA EGLGLDRDMV ISERRALPAT 130 140 150 160 170 180 RFAVRAYVDF VRDRSLLEAV ASSLTEMFSP TIISERVSGM LANYDFITRE TLAYFNARLD 190 200 210 220 230 240 QAPRDADFAL DYVKRHARTP EQQQAAIAAL TFKCDVLWAQ LDALHHAYVS PGLIPPGAFG HDGIWS

References

[1]

"Complete sequence of chromosome of Acidiphilium cryptum JF-5." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000697 Genomic DNA. Translation: ABQ29308.1.
RefSeq	YP_001233227.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5162239.
GenomeReviews	Gene locus Acry_0079 in contig CP000697_GR.
KEGG	acr:Acry_0079.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A5FUM6. AWALNRY.
Family and domain databases
HAMAP	MF_00654. [Tree]
InterPro	IPR011845. PQQ_synth_PqqC. IPR004305. TENA/THI4/PQQ_synth_PqqC. [Graphical view]
Pfam	PF03070. TENA_THI-4. 1 hit. [Graphical view]
TIGRFAMs	TIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PQQC_ACICJ

Accession

Primary (citable) accession number: A5FUM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 12, 2007
Last modified:	June 16, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)